Class: Type (195)
Universal donor cells
Patent Number: 6916654This patent covers the modification of cells to make them "universal donors" and thus not be rejected by the immune system. Not only is it next to impossible to completely inhibit expression of all immunogenic MHC molecules, but even if this is accomplished, the influence of the NK cells which kill tissue not expressing MHC must also be...
Pluripotent mesenchymal stem cells and methods of use thereof
Patent Number: 5827735This patent provides a new type of stem cell that is similar to the mesenchymal stem cells covered by Osiris. It appears that the stem cells disclosed in this patent are derived from muscle cells. If these cells are mesenchymal or express the markers SH2-4 covered by Osiris, this could be an interesting patent to watch out for.
Method and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules
Patent Number: 6410320This patent covers a type of renal stem cell that is useful for generation of artificial nephrons and eventually artificial kidneys.
Methods and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules
Patent Number: 5429938This patent covers the isolation, expansion, and use of kidney stem cells in order to generate in vitro renal tubules. The compounds used for kidney stem cell expansion include retinoic acid, TGF, and EGF.
Preparation of pure cultures of post-mitotic human neurons
Patent Number: 5175103This patent covers one of the few stem cell therapies that actually entered clinical trials. The patent is for a teratocarcinoma cell line that is induced to differentiate into neurons with retinoic acid (and/or other factors) and then stops proliferating and can be used for cell therapy in stroke. The technology was eventually developed clinically by Layton Biosciences. Administration...
Retrovirus infecting primate bone marrow cells and harvesting both non-adherent and adherent cells
Patent Number: 5612206This patent covers transfection of primate bone marrow cells with genes that that gene therapy may be used. The patent provides amphotropic retroviral vectors for transfection of the bone marrow.
Hapatoblasts and method of isolating same
Patent Number: 6069005This patent discloses methods of purifying hepatic stem cells. These stem cells may be expanded and used for therapeutic purposes. One interesting application of this invention would be to tranfect embryonic stem cell cytoplasm into these hepatocyte stem cells and to see if we can increase their expansion capability. Theoretically hepatocytes should be easier to tranplant than other...
CD4.sup.+, latently HIV-1-infected hematopoietic progenitor cells
Patent Number: 5256534This patent covers a model of HIV infection. Specifically HIV infected stem cells of the hematopoietic type are infected and infection remains latent. HIV treatments may be assessed using this model of "stem cell" HIV infection.
Hepatic progenitors and method of isolating same
Patent Number: 6242252This patent covers a type of hepatic stem cell that expresses OX-43, OX-44, and/or OC3.
Multipotent neural stem cell compositions
Patent Number: 7,361,505Essentially, this patent covers: a) fetal and embryonic derived neurospheres; b) purified population of multipotent neural derived from juvenile or adult mammalian CNS tissue; and c) in vitro cell culture composition derived from mammalian CNS consisting of neurospheres.
Specific neurospheres include cells that resemble neuronal progenitor cells. The phenotype of...