Class: Type (195)
Human hematopoietic progenitor cell preparations and their expansion in a liquid medium
Patent Number: 6241984This patent covers autologous hematopoietic stem cell transplants with ex vivo expansion through an IL-3 + GM-CSF fusion protein, and/or with stem cell factor.
Human mesenchymal stem cells
Patent Number: 5486359Mesenchymal stem cells are propably the most advanced in terms of clinical development of all stem cell types, second only to bone marrow stem cell. This patent covers mesenchymal stem cells in general. Specifically a cell is claimed that is positive for the markers SH2, SH3, and SH4. The claimed cell is capable of differentiating into...
T lymphocyte precursor
Patent Number: 5583033This patent covers the stem cell that gives rise to T cells. The claims actually comprise methods of isolation of a precursor that is CD34+, Leu8+ and CD7+. This patent is useful not only for purifying T cell stem cells for ex vivo growth and expansion, but also for identifying the T cell precursor pool in patients with various...
Human hematopoietic stem cell
Patent Number: 5914108Provided are hematopoietic stem cells that are capable of reconsituting a hematopoietic system.
Human hematopoietic stem cell
Patent Number: 5763197This patent teaches the use of the CD34+, lineage negative hematopoietic stem cell as a target for the in vitro screening and identification of drugs. For example, libraries may be screened for ability to inhibit or stimulate proliferation, or alternatively to induce differentiation into various lineages.
Human hematopoietic stem cell
Patent Number: 5750397This is one of the composition of matter patents on hematopoietic stem cells. It covers the phenotype of CD34+ and Thy1+
Human hematopoietic stem cell
Patent Number: 5716827This is one of the patents on the composition of matter of hematopoietic stem cells, it covers a population of CD34+, Thy-1+ cells.
Human hematopoietic stem cell
Patent Number: 5061620This is another patent on the hematopoietic stem cell. It is filed later than Civin's, that is why this is an interesting patent. Furthermore it actually mention's Civin's patent "U.S. Pat. No. 4,714,680 describes a composition comprising human stem cells. " In any case, this current patent has 3 independent claims. The first covers "A cellular composition comprising human...
Gene delivery to periosteal cells by microneedle injection
Patent Number: 6525030The periosteum is a dense layer of connective tissue that wraps around bone. This patent teaches ways of transfecting this layer with various genes that are capable of stimulating stem cells and other cells to proliferate and/or differentiate.
Homologous recombination for universal donor cells and chimeric mammalian hosts
Patent Number: 5413923This patent teaches how to genetically delete the MHC antigens in order to have stem cells and progeny of the stem cells that are capable of acting as universal donor cells. Although this technology is at face value very interesting, the fact that other antigens besides MHC cause rejection of tissue dampens enthusiasm for this approach...