Class: Type (195)
Homologous recombination for universal donor cells and chimeric mammalian hosts
Patent Number: 6514752This patent discloses a stem cell theat has been modified so as to lack expression of MHC genes. The modification involves homologous recombination in a manner similar to which knockout mice are made. The cells are then used for transplantation since they are presumed to be less immunogeneic. If it was possible to generate liver cells through this method, then the...
Homologous recombination for universal donor cells and chimeric mammalian hosts
Patent Number: 5574205This patent covers generation of mice that lack MHC I and/or MHC II. Stem cell transplants are one of the transplants that the inventor believes can be performed with donor cells that lack MHC I and/or MHC II. Unfortunately the issue of rejection has to do not only with "major...
Universal donor cells
Patent Number: 6100443This patent covers non-human cells and stem cells that are "de-immunogenized" so that they may be transplanted into humans without rejection. The patent "de-immunogenizes" the cells by inducing expression of human anticomplement proteins, as well as by suppressing the expression of immunogenic proteins such as those of the MHC type.
Universal donor cells
Patent Number: 5705732This patent covers manipulated cells and stem cells that are not immunogeneic when inplanted into a recipient. Various means of reducing immunogenecity are disclosed such as expression of human complement inhibitors and deletion or suppression of MHC expression.
Propagatable, new combinant cells for cellular replacement therapy
Patent Number: 5175004This is a very interesting patent for generation of new cells and new stem cells. This patent is way ahead of its time. It teaches to take recipient cells from a degenerated organ, "rejuvenate" the cells by transplanting the nucleus of the old cell into a cytoplasm of a newer cell, generating a histocompatible cell population through this fusion, and transplanting the cells back into a...
Human liver epithelial cell lines
Patent Number: 5759765This patent teaches the use of immortalized human hepatic epithelial cells for testing toxicity of agents in vitro. This is a rapid and easy way to test for potential toxicity of various candidates without having to perform animal testing.
Primitive cell colony stimulating factors and lymphohematopoietic progenitor cells
Patent Number: 5256560There are numerous stem cell types in the bone marrow. Specific stem cells of the hematopoietic lineage were originally identified as being CD34+. In this patent, a CD34-stem cell is claimed that produces growth factors capable of stimulating hematopoiesis. This patent may be a really great candidate for developing since at first...
Homogeneous mammalian hematopoietic stem cell composition
Patent Number: 5087570This patent covers the use of the stem cell antigen (SCA-1) for determination of murine hematopoieitic stem cells. The patent has 1 independent claim that covers "A cell composition consisting essentially of as the cellular population viable murine hematopoietic Sca-1+ stem cells from a genetically identical or congenic source."
Yolk sac stem cells and their uses
Patent Number: 5744347This patent covers an early hematopoietic stem cell that is derived from the yolk sac. The yolk sac is actually the first site, or one of the first sites of hematopoiesis during development.
Human stem cells and monoclonal antibodies
Patent Number: 5035994This patent futher strengthens Civin's claim (no pun intended) on the hematopoietic stem cell. The first independent claim covers "A method of isolating a population of human cells containing pluripotent lympho-hematopoletic stem cells" through ANY ANTIBODY that bind to the antigen that is recognized by the antibody deposited with ATCC...