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Patents (1436 Stem Cell Patents)

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Class: Type (195)

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Method of isolating ependymal neural stem cells

Patent Number: 6541247

This patent covers stem cells of the ependymal CNS type from an animal that is non-embryonic. These neuronal stem cells can be isolated based on expression of Notch-1 receptor.

Inventors: Frisen, Jonas (Stockholm, SE); Janson, Ann Marie (Stockholm, SE); Johansson, Clas (Stockholm, SE); Momma, Stefan (Sp.ang.nga, SE); Clarke, Diana (Stockholm, SE); Zhao, Ming (Solna, SE); Lendahl, Urban (Sundbyberg, SE); Delfani, Kioumars (Solna, SE)

Assignee: Neuronova AB (Stockholm, SE)

Date of First Priority Issue: Monday May 25th, 1998

Bone marrow cells as a source of neurons for brain and spinal cord repair

Patent Number: 6528245

This patent teaches that bone marrow stromal cells may be used as a source of neurons or to assist in neuronal regeneration. One wonders if these bone marrow stromal cells are similar to the mesenchymal stem cells that are patented by Osiris Therapeutics.

Inventors: Sanchez-Ramos, Juan (Tampa, FL); Song, Shijie (Tampa, FL); Janssen, William (Tampa, FL); Sanberg, Paul (Spring Hill, FL); Freeman, Thomas (Tampa, FL)

Assignee: University of South Florida (Tampa, FL)

Date of First Priority Issue: Thursday May 7th, 1998

Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof

Patent Number:

This patent covers the extraction and use of a muscle derived stem cell that is positive for the markers desmin, CD34, flk-1 and M-Cadherin, but does not express the hematopoietic marker CD45 nor c-kit. This cell type is useful for treatment of a variety of disorders associated with muscle degeneration. Although the inventors state that...

Inventors: Chancellor; Michael B. (Pittsburg, PA), Huard; Johnny (Pittsburgh, PA), Capelli; Christopher C. (Kenosha, WI), Qu; Zhuqing (Pittsburgh, PA)

Assignee: Unknown Assignee(s)

Date of First Priority Issue: Friday May 1st, 1998

Engraftable human neural stem cells

Patent Number: 6528306

This patent uses human fetal telencephalon as a source of stem cells that can be implanted and subsequent to implantation actually interdigitate and function in unison with host neurons.

Inventors: Snyder, Evan Y. (Jamaica Plain, MA); Wolfe, John H. (Philadelphia, PA); Kim, Seung U. (Vancouver, CA)

Assignee: The Children's of Medical Center Corporation (Boston, MA); The University of British Columbia (CA); The University of Pennsylvania (Philadelphia, PA)

Date of First Priority Issue: Tuesday April 14th, 1998

Keratinocyte stem cells

Patent Number: 6485971

This patent covers a type of stem cell that gives rise to keratinocytes. These cells can be purified from skin biopsy and used for amplification and generation of numerous other cell types and tissue. One interesting possibility is the use of such keratinocyte stem cells for generation of artificial thymus.

Inventors: Kaur, Pritinder (East Melbourne, AU); Simmons, Paul J. (East Melbourne, AU)

Assignee: Peter MacCallum Cancer Institute (Victoria, AU)

Date of First Priority Issue: Wednesday March 18th, 1998

Human lineage committed cell composition with enhanced proliferative potential, biological effector function, or both; methods for obtaining same; and their uses

Patent Number: 6835566

This patent teaches the generation of lineage-committed dendritic cell progenitors. This is important since the dendritic cell is a master controller of the immune response, being able to both stimulate responses as well as inhibit them. Dendritic cells can be made to stimulate responses through activation with various cytokines or toll like receptors, whereas they can also suppress responses...

Inventors: Smith, Alan K. (Saline, MI); Smith, Douglas M. (Ann Arbor, MI); Mandalam, Ramkumar K. (Westland, MI)

Assignee: Aastrom Biosciences, Inc. (Ann Arbor, MI)

Date of First Priority Issue: Monday February 23rd, 1998

Purified populations of stem cells

Patent Number: 6852533

This is a powerful patent that covers essentially the endothelial precursor cell. The importance of endothelial precursors is their ability to induce angiogenesis. The patent has claims on any CD34 + VEGF R+ cell, as well as CD133+, VEGF R+ endothelial stem cell. Sources of these...

Inventors: Rafii, Shahin (Great Neck, NY); Witte, Larry (Stormville, NY); Moore, Malcolm A. S. (New York, NY)

Assignee: Cornell Research Foundation, Inc. (Ithaca, NY); Sloan-Kettering Institute for Cancer Research (New York, NY); ImClone System Incorporated (New York, NY)

Date of First Priority Issue: Friday January 23rd, 1998

Pluripotential bone marrow cell line and methods of using the same

Patent Number: 6082364

This patent seems to cover a cell that is very similar to the cell covered by Osiris...that is mesenchymal stem cells.

Inventors: Balian, Gary (Charlottesville, VA); Wang, Gwo-Jaw (Charlottesville, VA); Diduch, David (Charlottesville, VA); Hahn, Chang (Charlottesville, VA)

Assignee: Musculoskeletal Development Enterprises, LLC (Charlottesville, VA)

Date of First Priority Issue: Monday December 15th, 1997

Human embryonic germ cell line and methods of use

Patent Number: 6245566

This patent covers human primordial germ stem cells. These cells can be used for generating a variety of different stem cell lines, as well as for in vitro generation of various germ cells.

Inventors: Gearhart, John D. (Baltimore, MD); Shamblott, Michael Joseph (Baltimore, MD)

Assignee: The Johns Hopkins University School of Medicine (Baltimore, MD)

Date of First Priority Issue: Friday December 12th, 1997

Hematopoietic stem cells

Patent Number: 6537807

This patent is in competition with other composition of matter patents that cover hematopoietic stem cells. Specific phenotypes are covered by this patent, which may be the reason why it issued in light of several other patents that also cover similar phenotypes and activities.

Inventors: Smith, Clayton A. (Durham, NC); Storms, Robert W. (Durham, NC); Gilboa, Eli (Durham, NC)

Assignee: Duke university

Date of First Priority Issue: Thursday December 4th, 1997

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