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Patents (1436 Stem Cell Patents)

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Class: Differentiation (190)

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Cysteine variants of erythropoietin

Patent Number: 7,314,921

This patent covers the composition of matter for specific variants of erythropoietin, the renal secreted hormone responsible for generation of erythrocyte differentiation from bone marrow hematopoietic stem cells. Specifically, the patent covers variants of the erythropoietin molecule in which the amino acid cysteine is substituted for amino acids that are not essential for erythropoietin...

Inventors: Cox, III; George N. (Louisville, CO)

Assignee: Bolder Biotechnology, Inc. (Louisville, CO)

Date of First Priority Issue: Monday July 14th, 1997

Directed maturation of CD34 negative stem cells to programmable antigen presenting cells

Patent Number: 6586243

This patent teaches ways of generating dendritic cells from human hematopoietic stem cells and furthermore teaches how to pulse these dendritic cells with tumor antigens for use as cancer vaccines. This approach is similar in some ways to work performed by Eli Gilboa and the company Argos Therapeutics.

Inventors: Cezayirli, Cem (Birmingham, AL); Silvers, Mel (North Miami Beach, FL)

Assignee: Unknown Assignee(s)

Date of First Priority Issue: Wednesday July 2nd, 1997

Electrospraying apparatus and method for introducing material into cells

Patent Number: 6093557

This patent teaches methods of introducing materials into cells. It is useful for introducing genes into cells to cause differentiation, or alternatively introducing cytoplasm of embryonic stem cells into adult cells in order to "rejuvenate" them.

Inventors: Pui, David Y. H. (Plymouth, MN); Chen, Da-Ren (Lauderdale, MN)

Assignee: Regents of the University of Minnesota (Minneapolis, MN)

Date of First Priority Issue: Thursday June 12th, 1997

Keratinocyte culture from precursor cells

Patent Number: 5968546

This patent provides compositions for treatment of skin defects, including burn wounds, through culture and diffentiation of keratinocyte stem cells, and subsequent administration of the keratinocyte stem cells in vivo.

Inventors: Baur, Marcus (CH-1066 Epalinges, CH); Hunziker, Thomas (CH-3653 Oberhofen, CH); Limat, Alain (CH-1712 Tafers, CH); Riedel, Wolfram (D-869198 Utting, DE); Toloczyki, Christian (D-86919 Utting, DE)

Assignee: Unknown Assignee(s)

Date of First Priority Issue: Friday May 16th, 1997

Differentiation of human embryonic germ cells

Patent Number: 6562619

This patent teaches the utilization of ligands that activate gp130 for the induction of differentiation of embryonic germ stem cells.

Inventors: Gearhart, John D. (Baltimore, MD); Shamblott, Michael Joseph (Baltimore, MD)

Assignee: The Johns Hopkins University School of Medicine (Baltimore, MD)

Date of First Priority Issue: Monday March 31st, 1997

Formation of human bone in vivo using ceramic powder and human marrow stromal fibroblasts

Patent Number: 5914121

This patent teaches how to use bone marrow stromal cells (are they similar to mesenchymal stem cells??) for generation of artificial bone. The use of various matrices, including ceramic powder is disclosed for practicing this invention.

Inventors: Robey, Pamela Gehron (Bethesda, MD); Bianco, Paolo (Rome, IT); Kuznetsov, Sergei (Bethesda, MD); Rowe, David (West Hartford, CT); Krebsbach, Paul (Bethesda, MD); Mankani, Mahesh H. (Bethesda, MD)

Assignee: The United States of America as represented by the Secretary of the (Washington, DC)

Date of First Priority Issue: Wednesday February 12th, 1997

Directed maturation of stem cells and production of programmable antigen presenting dentritic cells therefrom

Patent Number: 6251665

This patent covers the use of hematopoietic stem cells to generate dendritic cells. The dendritic cells disclosed are able to elicit an antitumor immune response.

Inventors: Cezayirli, Cem (Birmingham, AL); Silvers, Mel (N. Miami Beach, FL)

Assignee: Unknown Assignee(s)

Date of First Priority Issue: Friday February 7th, 1997

Programmable antigen presenting cell of CD34 lineage

Patent Number: 6228640

Disclosed in this patent are methods of generating antigen-loaded dendritic cells useful for cancer immunotherapy, through the differentiation of hematopoietic stem cells.

Inventors: Cezayirli, Cem (Birmingham, AL); Silvers, Mel (North Miami Beach, FL)

Assignee: Unknown Assignee(s)

Date of First Priority Issue: Friday February 7th, 1997

Method for testing the differentiation status in pancreatic cells of a mammal

Patent Number: 5948623

This patent covers the use of the transcription factor Pax4 for identifying the number of pancreatic stem cells in an animal. This patent is useful for entities seeking to expand the number of pancreatic stem cells in vivo through administration of various compounds. One such example is the work by Transition Therapeutics utilizing gastrin with EGF for treatment of...

Inventors: Sosa-Pineda, Beatriz (Memphis, TN); Gruss, Peter (Gottingen, DE)

Assignee: Max-Planck Gesellschaft Zur Forderung der Wissenschaften E.V. (Berlin, DE)

Date of First Priority Issue: Tuesday December 31st, 1996

T cell differentiation of CD34+ stem cells in cultured thymic epithelial fragments

Patent Number: 5766944

Disclosed are methods of generating T cells in vitro from CD34+ hematopoietic stem cells. Specifically, the use of thymic fragments are provided so as to recapitulate in vivo thymopoiesis.

Inventor: Ruiz, Margaret Eileen (Chevy Chase, MD)

Assignee: Unknown Assignee(s)

Date of First Priority Issue: Tuesday December 31st, 1996

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