Class: Differentiation (190)
Serum-derived factor inducing cell differentiation and medical uses thereof
Patent Number: 6783775This patent teaches ways of inducing differentiation in stem cells. Specifically it claims a composition of matter that can induce not only differentiation of hematopoietic stem cells, but also of leukemic cells. The composition contains the enzyme ceruloplasmin, together with a specific serum derived component. This patent is ripe for commercialization.
Serum-derived factor inducing cell differentiation and medical uses thereof
Patent Number: 6372262This patent covers a factor derived from serum by chemical purification techniques that induces stem cell differentiation, and is able to induce differentiation of leukemic cells. Such factors have great possibilities in cancer therapy. Older work by Laurence Burton at the Immune Augmentative Therapy (IAT) clinic actually clinically used such factors with good results in mesothelioma...
Method of differentiating erythrocyte progenitor cells
Patent Number: 6147052Disclosed is the novel protein "Erythroid Differentiation and Denucleation Factor" (EDDF) which is capable of inducing production of red blood cells from hematopoietic stem cells both in vitro and in vivo. Methods of stimulating hematopoietic stem cells to generate various lineages of cells are important in medicine. It will be interesting to see if the EDDF also has...
Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage
Patent Number: 5928945This patent teaches how to generate cartilage through the growth of chondrocyte stem cells under shear stress. It is believed that the sheer stress activates certain mechanoreceptors which cause appropriate differentiation of the chondrocyte stem cells into cartilage.
Differentiation of granulocytic and monocytic progenitor cells
Patent Number: 6096540This patent teaches various proteins that can be used as discriminatory markers for distinguishing progenitors of the monocytic lineage from progenitors of the granulocytic lineages.
Medicament comprising HGF gene
Patent Number: 7,285,540Stimulation of angiogenesis is a method of treating numerous diseases associated with lack of oxygen, or ischemia. While numerous methods of inducing angiogenesis have been attempted (FGF injection, VEGF gene therapy, etc), there is still a need in the art for methods of reproducibly stimulating formation of new blood vessel development for conditions such as...
Adipogenic differentiation of human mesenchymal stem cells
Patent Number: 6709864This patent covers the generation of mesenchymal stem cells from adipose tissue. This is an interesting situation since Cytori and others have patents on stem cells from the adipose tissue, and Osiris has patents on mesenchymal stem cells from any tissue. It will be interesting to watch if there is litigation coming out of this patent in light of other patents and clinical trials. For...
Adipogenic differentiation of human mesenchymal stem cells
Patent Number: 6322784Mesenchymal stem cells can differentiate into a variety of cellular lineages. In this patent the ability of mesenchymal stem cells to be induced into the adipocyte lineage is covered.
Adipogenic differentiation of human mesenchymal stem cells
Patent Number: 5827740Treatment of mesenchymal stem cells with a glucocorticoid together with an agent that increases intracellular cAMP is disclosed as one of several methods for inducing the differentiation of mesenchymal stem cells into adipocytes.
Differentiation-suppressive polypeptide serrate-2 and methods of use
Patent Number: 7,138,276Notch is a receptor for Delta and Serrate that is found in Drosophila and involved in controlling nerve cell differentiation during development. The human equivalent of Notch is called TAN-1, and is expressed on hematopoietic stem cells.
Other patents have used Notch ligand homologues to stimulate fetal...