Class: Extraction/Preservation (156)
Monoclonal antibodies to mesenchymal stem cells
Patent Number: 7,476,540This patent covers antibodies that bind to mesenchymal stem cells. The antibodies are deposited as hybridomas under accession numbers KCLRF-BP-000123, KCLRF-BP-000124 or KCLRF-BP-000125 at the Korean Cell Line Research Foundation (Cancer Research Institute, Seoul National University, College of Medicine, 28 Yongondong, Chongno-Gu, Seoul, 110-744, Korea). The antigen appears to be...
Cord blood and placenta collection kit
Patent Number: 7,147,626Celgene, through its wholly owned subsiduary Anthrogenesis (now called Celgene Cellular Therapeutics) has been active in the cord blood IP area, through patents covering innovative methods of extracting stem cells from the placental matrix itself . In the current patent, Celgene covers a kit for collecting not only the umbilical...
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Methods for identifying stem cells based on nuclear morphotypes
Patent Number: 7,427,502Stem cells are usually identified based on markers such as CD34 for hematopoietic stem cells, or CD133 for cancer stem cells, or specific properties such as expression of aldehyde dehydrogenase. Interestingly, in this patent the morphological characteristics of the stem cell are covered...
Preparation of a cell concentrate from a physiological solution
Patent Number: 7,291,450The use of bone marrow mononuclear cells as a source of stem cells has been widely described in numerous medical procedures ranging from stimulation of angiogenesis in patients with peripheral artery disease to treatment of terminal liver failure, to treatment of heart disease. Unfortunately the use of...
Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same
Patent Number: 7,342,110One of the major technological advances that allowed for the characterization and use of stem cells was the development of defined monoclonal antibodies that repeatedly attached to markers on stem cells. For example, the patents covering the original hematopoietic stem cells used monoclonal antibodies to actually identify the cell...
Stem cell-specific promoters and their use
Patent Number: 7,396,680The current patent covers the nucleic acid sequences for promoters. In the claims it just states "promoters" but the specification teaches that the promoters are specific to "stem cells". The examples part of the patent teaches that they are active in CD34 and CD133 cells found from cord blood.
Being able to have patents on actual promoter sequences that...
Methods of identifying and isolating stem cells and cancer stem cells
Patent Number: 7,217,568This patent teaches that tumor stem cells can be extracted population of non-stem cells by selecting for the cells which have activation of the transcription factor LEF/TCF and/or the beta.-catenin pathway. This patent essentially takes a pathway that is known to be activated in non-malignant sttem cells and simply applies it to malignant stem cells. Some may...
Two-stage culture protocol for isolating mesenchymal stem cells from amniotic fluid
Patent Number: 7101710This patent useful for parties looking for methodologies to purify mesenchymal stem cells from amniotic fluid. The patent has 3 independent claims. Essentially all three are directed towards a two step culture process where amniotic fluid cells are first grown in a vessel, subsequently non-adherent cells are isolated, and allowed to expand. The difference between the claims is the media used...
Progenitor cells from wharton's jelly of human umbilical cord
Patent Number: 7,547,546This patent covers methods of extracting an adherent mesenchymal-like stem cells from the Wharton's Jelly of the umbilical cord. The extracted cells are negative for MHC and are termed by the inventors human umbilical cord perivascular (HUCPV) cells. In the examples section the the cells are demonstrated to be capable of differentiating into osteocytes, chondrocytes, adipocytes, and...
Bone marrow aspiration system
Patent Number: 6981948As mentioned in our discussion about patent # 7008394, bone marrow harvesting is a relatively invasive procedure. This is also very relavant for regenerative uses of bone marrow where patients with a heart attack or stroke are harvested. Accordingly there is a need to develop less invasive and increasingly sterile means of harvesting. The current patent has two independent claims covering...