Patents

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Methods and compositions for modulating telomerase reverse transcriptase (TERT) expression

Patent Number: 7,279,328
This patent covers a screening system for assaying small molecule libraries for telomerase stimulating activity. Specifically, the inventors have found that telomerase reverse transcriptase (TERT) activity can be modulated by agents that alter the binding interaction of the GC-Box 5 repressor site with a repressor protein (or protein complex including the same). Using this system the inventors...

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Differentiation of bone marrow cells into neuronal cells and uses therefor

Patent Number: 7,279,331
This patent covers the differentiation of bone marrow stromal stem cells into neurons through the addition of antioxidants. The patent is limited to in vitro differentiation. Specific antioxidants that the inventors cover for the in vitro generation of neurons include beta-mercaptoethanol, dimethylsulfoxide, butylated hydroxytoluene, butylated hydroxyanisole, ascorbic acid, dimethylfumarate...

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Method of isolating ependymal neural stem cells

Patent Number: 7,279,332
It is believed that neural stem cells are found in large quantities in the ependyma (the thin epithelial membrane lining the ventricular system of the brain and the spinal cord canal). The ependyma is one of 4 types of neuroglia and its primary function is the production of cerebrospinal fluid. The current patent covers the assessment of test compounds for modulation of...

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Osteogenesis-promotion enhancer and method of screening the same

Patent Number: 7,276,525
This patent covers 2 main concepts. The first is acceleration of osteogenesis through administration of a bone morphogenic protein together with an inhibitor of TGF-beta. The claims also go on to cover a specific chemical entitiy that inhibits TGF-beta. The second main part of the patent is claim 3 in which the screening of compounds that inhibit TGF-beta and thereby promote BMP-induced...

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Stimulation of hematopoietic cells in vitro

Patent Number: 7,276,371
Ex vivo expansion of CD34 hematopoietic stem cells is a highly desired goal. If it was possible to effectively expand these cells, then not only would autologous hematopoietic stem cell transplants be more clinically successful, but also numerous ex vivo cellular therapies would be possible. Unfortunately, many companies have developed numerous ex vivo cell expansion methodologies for CD34 cells...

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Compositions and methods for inducing osteogenesis

Patent Number: 7,273,864
This is a composition of matter patent on a series of compounds capable of inducing generation of bone tissue by inducing maturation of bone precursor cells and/or inducing transdifferentiation. The examples section shows that treating mesenchymal stem cells in vitro with the compounds induces formation of osteocytes, as well as synergy with certain members of the bone morphogenic protein...

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Human and mammalian stem cell-derived neuron survival factors

Patent Number: 7,273,725
This is a composition of matter patent covering polypeptide sequences for "Stem cell-Derived Neuron Survival Factors" (SDNSF). The polypeptides appear to be secretory and to represent natural factors that induce neural stem cell self-renewal and differentiation. In the examples section the inventors treated neurospheres with SDNSF and demonstrated increased number of cells expressing the...

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Industrial production of meat using cell culture methods

Patent Number: 7,270,829
This patent teaches what a friend of mine used to call the notion of "biobeef". The concept of generating edible meat through tissue culture. The patent has one independent claim which essentially covers the use of cultured cells to generate a three dimensional tissue that can be eaten that does not require "deboning, removal of offal and/or tendon and/or gristle and/or fat". This patent...

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Method of concentrating and separating dopaminergic neurons

Patent Number: 7,270,998
Selection of cells with specific phenotypes is a critical part of the development of stem cell therapeutics. Several patents are issued on methods of selecting differentiated cells with a specific phenotype from a heterogenous population. In the current patent 5 independent claims are issued covering the isolation of dopamine producing cells by the selection of cells which have an active...

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Compositions and methods for promoting tissue regeneration

Patent Number: 7,271,187
This patent has one issued claim covering treatment of bone marrow cells with a compound (N-[4-[4-fluorophenyl)sulfonyl]phenyl]acetamide) and subsequent administration of the treated cells as a remedy for spinal cord injury.

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