Patents
Antibodies isolating and/or identifying neuronal stem cells and method for isolating and/or identifying neuronal progenitor cells
Patent Number: 7,182,946Methods of purifying stem cells, as well as progenitor cell populations are well known in the art. Unfortunately, some of these methods have certain limitations, and as a result, there is always a great need to identify new ways of sometimes doing the same thing. For example, it is known that CD34 is a useful marker for hematopoietic stem cells. However, since the patent on CD34 has a limited...
Inventors: Buehring; Hans-Joerg (Tuebingen, DE), Vogel; Wichard (Tuebingen, DE)
Assignee: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum (Tuebingen, DE)
Date of First Priority Issue: Monday September 9th, 2002
Method of suppressing differentiation by administering a human serrate-1 polypeptide
Patent Number: 7,179,622This patent covers composition of matter and use for polypeptides derived from Notch agonists. The particular Notch agonist is Serrate, which is involved in maintaining an undifferentiated state in stem cells. The invention is useful for expanding hematopoietic stem cells without inducing their differentiation. The inventors provided some evidence of CD34 self renewal without...
Inventors: Sakano; Seiji (Fuji, JP), Itoh; Akira (Fuji, JP)
Assignee: Asahi Kasei Kabushiki Kaisha (Osaka, JP)
Date of First Priority Issue: Friday November 17th, 1995
Device and a process for expansion of haemopoeitic stem cells for therapeutic use
Patent Number: 7,179,643The problem with cord blood as a source of stem cells is that not many cells can be harvested. Although enough cells are usually present to treat a pediatric patient, in cases of adults, expansion of stem cells from the cord blood is desirable. The current patent provides a portable bioreactor for expansion of cord blod stem cells. Essentially, the invention is designed so as to be able to be...
Inventors: Rao; Sreemushnan Gopalkrishna Anando (Mumbai, IN), Tipnis; Shabari Pradeep (Mumbai, IN)
Assignee: Reliance Life Sciences Pvt. Ltd. (Maharashtra, IN)
Date of First Priority Issue: Thursday June 14th, 2001
Methods for regeneration of a mammalian lens
Patent Number: 7,176,189This patent covers the induction of dedifferentiation, followed by transdifferentiation for regenerating mammalian lens. The patent covers the steps of inducing dedifferentiation in an eye lens using a surgical procedure, followed by inducing the transdifferentation through administration of guanosine, and then “fixing” the transdifferentiated effect through abministration of...
Inventors: Baranowitz; Steven (Madison, NJ)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday May 1st, 2001
Biocompatible crosslinked composition
Patent Number: 7,176,256Surgical adhesions cause excess fibrosis in an area that has been surgically manipulated. Adhesions are a major cause of post operative morbidity. In this patent biodegradable polymers are disclosed that are useful for covering post surgical areas in order to inhibit formation of adhesions. Essentially, the patent covers crosslinked polymer compositions in which the first synthetic polymer...
Inventors: Rhee; Woonza M. (Palo Alto, CA), DeLustro; Frank A. (Belmont, CA), Berg; Richard A. (Los Altos, CA)
Assignee: Angiotech Pharmaceuticals, Inc. (North Bend, WA)
Date of First Priority Issue: Monday December 18th, 1995
Antisense oligonucleotides to type I procollagen
Patent Number: 7,173,122One of the potential problems with stem cell therapy is the propensity of certain cell types to contribute to scar formation. For example, during embryonic healing, scars are not formed on injured tissues, however, adult injured tissue is prone to scarring. Formation of scars is especially relevant in the post-myocardial infarct situation in which the non-functional scar tissue replaces...
Inventors: Beri; Rajinder (Loughborough, GB)
Assignee: Nath Rahul Kumar (Houston, TX)
Date of First Priority Issue: Wednesday December 15th, 1999
Inhibitors of proteasomal activity for stimulating hair growth
Patent Number: 7,175,994Stimulation of dermal papillary cells for hair regrowth is an area of intense scientific interest. In the current patent, the use of proteosomal inhibition in general is claimed, along with several growth factors for stimulation of hair growth. Specifically covered growth factors are EGF, FGF, PDGF, TGF, IGF, LIF, and parathyroid hormone. This patent also covers the use of specific compositions...
Inventors: Garrett; I. Ross (San Antonio, TX), Rossini; Jorge Gianny (San Antonio, TX), Gutierrez; Gloria (San Antonio, TX)
Assignee: Osteoscreen IP, LLC (San Antonio, TX)
Date of First Priority Issue: Friday July 10th, 1998
Aryl-containing 5-acylindolinones, the preparation thereof and their use as medicaments
Patent Number: 7,176,231Although much effort in stem cell therapeutic development is being focused on administration of exogenous stem cells, one area that is generally being overlooked is methods of activating/expanding endogenous stem cells. It was recently published that the in vivo inhibition of the enzyme GSK-3 promotes hematopoietic stem cell self renewal (Trowbridge et al. Glycogen synthase kinase-3 is an in vivo...
Inventors: Heckel; Armin (Biberach, DE), Roth; Gerald Juergen (Biberach, DE), Kley; Joerg (Mittelbiberach, DE), Hoerer; Stefan (Ochsenhausen, DE), Uphues; Ingo (Ummendorf, DE)
Assignee: Boehringer Ingelheim International GmbH (Ingelheim, DE)
Date of First Priority Issue: Friday March 12th, 2004
CaR receptor as a mediator of migratory cell chemotaxis and/or chemokinesis
Patent Number: 7,176,243The area of stem cell mobilization is very exciting not only from the perspective of allowing for efficient harvest of peripheral blood stem cells, but also from the perspective of one day being able to mobilize endogenous stem cells to accelerate healing of various organs. In this patent a novel method of inducing mobilization of stem cells from the bone marrow, as well as inhibiting migration...
Inventors: Poznansky; Mark C. (Charlestown, MA), Scadden; David T. (Weston, MA), Olszak; Ivona T. (Charlestown, MA), Brown; Edward M. (Milton, MA)
Assignee: The General Hospital Corporation (Boston, MA); The Brigham and Women's Hospital, Inc. (Boston, MA)
Date of First Priority Issue: Monday May 1st, 2000
Endothelial cells derived from primate embryonic stem cells
Patent Number: 7,176,023It is known that endothelial cell dysfunction is one of the major causes of morbidity and mortality in the Western world. For example, if endothelium could properly respond to the hypoxic conditions associated with cardiac angina and form new blood vessels, then heart disease would take such a heavy toll on today’s society. This is just a limited example, atherosclerosis, various tissue...
Inventors: Kaufman; Dan S. (Woodbury, MN), Lewis; Rachel (Madsion, WI), Auerbach; Robert (Middleton, WI)
Assignee: Wisconsin Alumni Research Foundation (Madison, WI)
Date of First Priority Issue: Thursday November 1st, 2001