Patents

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Marker system for preparing and characterizing high-quality human embryonic stem cells

Patent Number: 7,153,650
This patent covers the use of the gastrin related peptide receptor (GRP receptor) as a marker of embryonic stem cell differentiation. Essentially when embryonic stem cells differentiate they start to downregulate expression of GRP receptor. This assay is useful for knowing the state of differentiation of embryonic stem cells. Since Geron is anticipating to enter clinical trials shortly, the...

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Interventions to mimic the effects of calorie restriction

Patent Number: RE39,436
Caloric restriction is the only sure way to increase life span. This patent covers the use of a screening systems so as to be able to identify compounds that mimic the effects of caloric restriction so that people don't have to starve themselves to live longer. The patent covers assessing gene expression, mRNA levels, and protein expression from people (or animals) that have been calorically...

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Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith

Patent Number: 7,153,501
It is known that various hematopoietic cells are involved in the ocular injury caused by uncontrolled angiogenesis. This occurs, for example, in wet macular degeneration, a disease in which antiangiogeneic agents are clinically used successfully. Since hematopoietic lineage cells are known to enter the ocular areas and assist in angiogenesis, the inventors asked why not use these cells as a...

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Pluripotential embryonic stem cells and methods of making same

Patent Number: 7,153,684
This patent covers ways of generating human embryonic stem cells. Some of the claims have priority to the WARF patents. Essentially the patent teaches that embryonic stem cells can be generated by culture of primordial germ cells in agents such as bFGF, SF and LIF. The cells described in the patent appear to have all the...

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Production of megakaryocytes by the use of human mesenchymal stem cells

Patent Number: 7,153,500
This patent covers a method of increasing megakaryocytes (precursors of platelets) to patients that are deficient in these cells. Specifically, there are two claims to the patent. The first covers the increasing of megakarocyte numbers by administration of mesenchymal stem cells. The second covers a method of increasing megakaryocyte numbers through administration of CD34 stem cells together...

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Telomerase immortalized neural progenitor cells

Patent Number: 7,150,989
Telemerase is critical for maintain telomere length and preventing senescence once cells have reached the Hayflick limit. This patent teaches the use of transfection with telomerase reverse transcriptase in order to generate neural progenitors that are immortal. The patent covers a wide variety of neural progenitors and sources of neural progenitors, including, dopaminergic, cholinergic, and...

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Compositions of enriched central nervous system stem cell and progenitor cell populations

Patent Number: 7,153,686
This patent covers a "Neurosphere Initiating Cell" isolated by its expression of the marker CD133. CD133 is expressed in a variety of stem cells and was recently shown to be found on cancer stem cells as well. Essentially, neurospheres are aggregates of neural cells that are grown in tissue culture. Generally neurospheres are...

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Injectable hyaluronic acid derivative with pharmaceuticals/cells

Patent Number: 7,157,080
This patent covers specific types of hyaluronic acid derivatives that are useful for administering cells into a soft tissue that is injured. Specifically, the patent is useful for treatment of intra-articular injuries by providing a means to administer cells so that the cells will be able to take the particular in vivo shape that is unique to the patient being treated. The patent has 2...

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Cord blood and placenta collection kit

Patent Number: 7,147,626
Celgene, through its wholly owned subsiduary Anthrogenesis (now called Celgene Cellular Therapeutics) has been active in the cord blood IP area, through patents covering innovative methods of extracting stem cells from the placental matrix itself . In the current patent, Celgene covers a kit for collecting not only the umbilical...

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Method for generating primate trophoblasts

Patent Number: 7,148,062
It is known that embryonic stem cells can be differentiated into a wide variety of tissues in vitro. In this patent, methods are disclosed for generating trophoblasts from ES cells through culture in BMP2, BMP4, BMP7, and GDF5. Although the patent teaches uses of the trophoblasts generated for research purposes, a very interesting possibility is to use them as a source of tumour antigens given...

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