Patents
Cysteine variants of granulocyte-macrophage colony-stimulating factor
Patent Number: 7,148,333G-CSF is a potent hematopoietic stem cell growth factor used clinically under the name Neupogen, made by Amgen, for accelerating granulopoiesis. One of the disadvantages of protein therapeutics in general is poor bioavailability and short half life. The current patent discloses methods of modifying G-CSF so as to allow for site-specific conjugation with polyethylene glycol which is generally...
Inventors: Cox, III; George N. (Louisville, CO)
Assignee: Bolder Biotechnology, Inc. (Boulder, CO)
Date of First Priority Issue: Monday July 14th, 1997
Composition and method for the repair and regeneration of cartilage and other tissues
Patent Number: 7,148,209Repair of cartilage is an area of active investigation using a wide variety of approaches, including bone marrow mesenchymal stem cells and various progenitor cell types. In this patent, methods of inducing cartilage regeneration are disclosed through administration of a solution that contains a mixture of various blood components and polymers. In certain embodiments the polymers are liquid...
Inventors: Hoemann; Caroline D. (Montreal, CA), Buschmann; Michael D. (Montreal, CA), McKee; Marc D. (Westmount, CA)
Assignee: Ecole Polytechnique (Montreal, CA)
Date of First Priority Issue: Thursday June 29th, 2000
Methods and compositions for tissue regeneration
Patent Number: 7,144,729This patent covers a novel method of treating wounds through "spraying" allogeneic cells, together with fibrinogen and thrombin, in order to secrete various growth factors, including factors that stimulate stem cells, so as to accelerate wound healing. Systems for inducing tissue regeneration, as well as kits are provided. Basically, the independent claim covers a two part administration of a...
Inventors: Rolland; Eric (Divonne les bains, FR), Hunziker; Thomas (Oberhofen, CH), Mis; Beatrice (Lausanne, CH), Rinsch; Christopher (Lausanne, CH)
Assignee: DFB Pharmaceuticals, Inc. (Fort Worth, TX)
Date of First Priority Issue: Friday September 1st, 2000
SCF antibody compositions and methods of using the same
Patent Number: 7,144,731Amgen has developed a strong patent portfolio covering the hematopoietic stimulating cytokine called Stem Cell Factor. Subsequently it was demonstrated that stem cell factor is capable of stimulating a variety of other stem cells in addition to hematopoietic stem cells. As part of its IP portfolio covering stem cell factor, Amgen has patented antibodies to the cytokine. This current patent...
Inventors: Zsebo; Krisztina M. (Thousand Oaks, CA), Bosselman; Robert A. (Thousand Oaks, CA), Suggs; Sidney V. (Newbury Park, CA), Martin; Francis H. (Thousand Oaks, CA)
Assignee: Amgen Inc. (Thousand Oaks, CA)
Date of First Priority Issue: Monday October 16th, 2006
Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto
Patent Number: 7,144,997This patent covers the use of hedgehog proteins and various analogues for maintaining neuron and neuronal stem cell viability. The claims cover specific compositions of matter, whereas the specification teaches various means of using the compositions of matter for protecting dopaminergic neurons from cell death. The basis of this patent is described in another
Assignee: Curis, Inc. (Cambridge, MA)
Date of First Priority Issue: Thursday July 24th, 1997
Method of producing a mouse suitable for the engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse
Patent Number: 7,145,055The use of immunodeficient animals in stem cell research is very important since most researchers are interested in the in vivo activities of human stem cells without having to actually perform clinical trials. The solution to this has been the use of animal strains that are either genetically immune deficient, or induced to be immune deficient. Previously the NOD-SCID mouse was used to...
Inventors: Method of producing a mouse suitable for the engraftment, differentiation and proliferation of heterolIto; Mamoru (Kanagawa, JP), Kobayashi; Kimio (Kanagawa, JP), Nakahata; Tatsutoshi (Kyoto, JP), Tsuji; Koichiro (Tokyo, JP), Habu; Sonoko (Tokyo, JP), Koy
Assignee: Central Institute for Experimental Animals (Kanagawa, JP)
Date of First Priority Issue: Friday December 1st, 2000
Chimeric bird from embryonic stem cells
Patent Number: 7,145,057Trangenic animals have been very useful in the basic sciences in terms of elucidating biological activities of specific proteins in an in vivo situation. In terms of developing therapeutics, transgenic animals are useful for a wide variety of practical purposes ranging from in vivo production of recombinant proteins for human use, to serving as bioincubators for tissue and three-dimensional...
Inventors: Van de Lavoir; Marie-Cecile (San Francisco, CA), Etches; Robert J. (San Mateo, CA), Heyer; Babette (Menlo Park, CA), Diamond; Jennifer (Millbrae, CA), Mather; Christine (Millbrae, CA), Beemer; Kathleen (Pacifica, CA), Myers; Heather (Danville, CA)
Assignee: Origen Therapeutics, Inc. (Burlingame, CA)
Date of First Priority Issue: Friday February 1st, 2002
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Methods for making and delivering rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof
Patent Number: 7,141,428Stem cells are increasingly seen as a source for the generation of new neurons. In this patent, ways of protecting neurons and stimulating axon regrowth are thought. Specifically, the patent deals with two GTPases called Rho and Rac. Rac activation causes axon spreading, while Rho activation causes axon retraction. In many neurodegenerative diseases, axons are retracted and important neural...
Inventors: McKerracher; Lisa (Ile des Soeurs, Quebec, CA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Thursday November 2nd, 2000
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Wound and cutaneous injury healing with a nucleic acid encoding perlecan
Patent Number: 7,141,551Perlecan is a proteoglycan (A molecule that contains both protein and glycosaminoglycans, which are a type of polysaccharide) that is found in the basement membrane. Upregulation of perlecan expression is observed during wound healing, as well as VEGF-mediated tumor angiogenesis. It is known that perlcan binds to numerous growth factors including FGF family members. It is also known that...
Inventors: DeCarlo; Arthur A. (Weston, FL), Whitelock; John (Homebush 2140, Sydney, AU)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday April 22nd, 2003
Purposeful movement of human migratory cells away from an agent source
Patent Number: 7,141,363Chemotactic gradients are critically important in stem cell function. This is demonstrated not only in the fact that the bone marrow constitutively secretes SDF-1 in order to allow systemically infused stem cells to home back to the bone marrow, but also in regenerative medicine where injured tissue releases chemokines to attract endogenous stem cells. The current patent deals with the...
Inventors: Poznansky; Mark C. (Charlestown, MA), Luster; Andrew D. (Wellesley, MA), Scadden; David T. (Weston, MA)
Assignee: The General Hospital Corporation (Boston, MA)
Date of First Priority Issue: Thursday April 8th, 1999