Patents
Devices and methods for treating defects in the tissue of a living being
Patent Number: 7,166,133Non-healing bone injuries pose a significant burden on our medical system. This new patent owned by the Kensey Nash Corporation provides a novel method for accelerating bone healing through providing an implantable matrix that contains collagen and "osteoinductive" factors. These factors may be proteins or cells according to the invention. The first independent claim of the patent covers an...
Inventors: Evans; Douglas G. (Downingtown, PA), Goldman; Scott M. (Paoli, PA), Kronengold; Russell T. (Lansdale, PA)
Assignee: Kensey Nash Corporation (Exton, PA)
Date of First Priority Issue: Sunday January 13th, 2002
Remyelination of neurons using multipotent neural stem cell progeny
Patent Number: 7,166,277This patent is useful for the cell therapy of diseases associated with demyelination such as multiple sclerosis. The patent covers the use of neural stem cells expanded ex vivo for the purpose of remyelinating neurons in vitro and in vivo. Specifically the patent covers use of nestin positive progenitors purified from CNS tissue treated with various differentiation factors such EGF and FGF...
Inventors: Weiss; Samuel (Alberta, CA), Reynolds; Brent (Alberta, CA), Hammang; Joseph P. (Barrington, RI)
Assignee: Neurospheres Holdings Ltd. (Calgary, CA)
Date of First Priority Issue: Monday July 8th, 1991
Artery smooth muscle- and vein smooth muscle-specific proteins and uses therefor
Patent Number: 7,163,808The use of stem cells for stimulation of angiogenesis is of great interest to current researchers. The ability of stem cells to stimulate angiogenesis is dependent not only on differentiation of stem cells into endothelial cells, but also by virtue of stem cell secreted growth factors that promote localized tissue remodeling and proliferation of endogenous endothelial precursors. The current...
Inventors: Anderson; David J. (Altadena, CA), Garcia-Cardena; Guillermo (Boston, MA), Gimbrone, Jr.; Michael A. (Plain, MA), Wang; Hai U. (Eldorado Hills, CA)
Assignee: California Institute of Technology (Pasadena, CA); The Brigham and Women's Hospital, Inc. (Boston, MA)
Date of First Priority Issue: Monday November 20th, 2000
Versican and epithelial-mesenchymal interaction
Patent Number: 7,163,679Versican is a chondroitin sulfate proteoglycan that is considered part of the extracellular matrix. Various isoforms of Versican exist, some associated with specific stages of development. In this patent the inventors found that versican-expressing dermal papilla (DP) cells have the ability to induce hair generation. Accordingly, the patent aims at screening agents that may be used to induce...
Inventors: Kishimoto; Jiro (Yokohama, JP), Burgeson; Robert (Marblehead, MA)
Assignee: The General Hospital Corporation (Boston, MA)
Date of First Priority Issue: Thursday May 6th, 1999
Peptide with osteogenic activity
Patent Number: 7,163,920This patent discloses a novel peptide that is capable of inducing osteoblast proliferation and induction of bone synthesis. The peptide disclosed may be used as part of an implantable composition of cells and biodegradable matrices for the treatment of bone fractures. The patent covers numerous methods of making the peptide, as well as chemical derivatives and methods of administration...
Inventors: Dhanaraj; Sridevi (Raritan, NJ), Gosiewska; Anna (Skillman, NJ), Rezania; Ali (Hillsborough, NJ), Heavner; George A. (Malvern, PA), Lin; Xuanhan (Bridgewater, NJ), Yi; Chin-Feng (Hillsborough, NJ)
Assignee: Ethicon, Inc. (Somerville, NJ)
Date of First Priority Issue: Tuesday September 30th, 2003
Bioartificial liver system
Patent Number: 7,160,719This patent covers the use of spheroid hepatocytes and hepatocyte progenitors in liquid culture, in such a manner that they may function as a bioartificial liver. Specifically, the patent teaches that previous artificial liver approaches had certain limitations that did not allow maximal growth and function of hepatocytes ex vivo. The current invention provides various medical device...
Inventors: Nyberg; Scott L. (Rochester, MN)
Assignee: Mayo Foundation for Medical Education and Research (Rochester, MN)
Date of First Priority Issue: Friday June 7th, 2002
Human cord blood as a source of neural tissue for repair of the brain and spinal cord
Patent Number: 7,160,724There is currently great interest in the use of cord blood stem cells for neuroregenerative purposes. This patent covers the ex vivo growth of cord blood cells in EGF, FGF2, NGF, and retinoic acid in order to generate a population of cells that contain neuronal-like properties. Evidence of activity of these neural precursors is provided in the examples section which describes post-CNS injury...
Inventors: Sanberg; Paul (Spring Hill, FL), Sanchez-Ramos; Juan (Tampa, FL), Willing; Alison (Tampa, FL), Richard; Daniel D. (Sedona, AZ)
Assignee: University of South Florida (Tampa, FL)
Date of First Priority Issue: Thursday March 9th, 2000
Hedgehog signaling promotes the formation of three dimensional cartilage matrices
Patent Number: 7,160,725It is known that hedgehog proteins are involved in pattern specification during embryogenesis. The possibility of modulating the hedgehog signalling pathway for regulation of stem cell activity was previously patented for hematopoietic stem cells, neural stem cells and
Assignee: Curis, Inc. (Cambridge, MA)
Date of First Priority Issue: Tuesday November 13th, 2001
Cultured cells from pancreatic islets
Patent Number: 7,157,278The possibility of ex vivo expansion of islets has been a goal of cell therapy researchers for decades. This patent teaches methods of isolating beta precursor cells from pancreatic islets, expansion ex vivo through culture in serum-free growth factors, and the possible use for replacement therapy in diabetics. Identification of islet precursors is performed by assessment of nestin and pdx1...
Inventors: Jin; Jianjian (Quincy, MA)
Assignee: Organogenesis, Inc. (Canton, MA)
Date of First Priority Issue: Wednesday December 4th, 2002
Methods for assisting recovery of damaged brain and spinal cord using arrays of X-ray microplanar beams
Patent Number: 7,158,607One of the problems with cell therapy after injury is the possibility of accelerating scar tissue formation. The current patent teaches the use of X-rays, administered by parallel micro-beams at doseages that are sufficient to remove inhibitors of regeneration. The patent also discloses the use of exogenous stem cells in combination with the X-rays in order to accelerate healing.
Inventors: Dilmanian; F. Avraham (Yaphank, NY), McDonald, III; John W. (Baltimore, MD)
Assignee: Brookhaven Science Associates, LLC (Upton, NY)
Date of First Priority Issue: Thursday February 10th, 2005