Patents
Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
Patent Number: 7,138,275This patent is highly interesting in that the inventors claim to have devised a simple and easy to implement methodology for generation of autologous stem cells. Essentially, the invention teaches that culturing of peripheral blood monocytes in the presence of IL-3 and M-CSF for approximately 6 days, somehow induces a program of de-differentiation in the monocytes to endow them with stem cell...
Inventors: Kremer; Bernd Karl Friedrich (Kiel, DE), Fandrich; Fred (Kiel, DE), Ruhnke; Maren ne (Kiel, DE)
Assignee: Blasticon Biotechnologische Forschung GmbH (Keil, DE)
Date of First Priority Issue: Thursday March 28th, 2002
8 Comments
8 Comments
Differentiation-suppressive polypeptide serrate-2 and methods of use
Patent Number: 7,138,276Notch is a receptor for Delta and Serrate that is found in Drosophila and involved in controlling nerve cell differentiation during development. The human equivalent of Notch is called TAN-1, and is expressed on hematopoietic stem cells. Other patents have used Notch ligand homologues to stimulate fetal hemoglobin synthesis as...
Inventors: Sakano; Seiji (Shizuoka, JP), Itoh; Akira (Shizuoka, JP)
Assignee: Asahi Kasei Kabushiki Kaisha (Osaka, JP)
Date of First Priority Issue: Tuesday July 16th, 1996
Method of treating dopaminergic and GABA-nergic disorders
Patent Number: 7,138,492It is known that hedgehog proteins are important in specifying what cells give rise to what tissues during development. Others have patented using hedgehog proteins for stimulating insulin production. In this patent the inventors found a new use for hedgehog proteins besides their known role in embryogenesis. Initially, the...
Inventors: Miao; Ningning (Palo Alto, CA), Wang; Monica (Marblehead, MA), Mahanthappa; Nagesh K. (Cambridge, MA), Jin; Ping (Boston, MA), Pang; Kevin (Belmont, MA)
Assignee: Curis, Inc. (Cambridge, MA)
Date of First Priority Issue: Thursday July 24th, 1997
Use of Xenopus laevis oocytes a microincubators
Patent Number: 7,135,336The concept of "de-differentiation" of cells is very attractive from a therapeutic perspective since it offers the possibility of generating autologous stem cells from somatic tissue. If one could devise a method for generating even minute numbers of totipotent stem cells from autologous tissue, these cells could be expanded and used to treat almost any illness. The use of nuclear transfer for...
Inventors: Paylian; Sergei (Knoxville, TN)
Assignee: University of South Florida (Tampa, FL)
Date of First Priority Issue: Wednesday April 21st, 2004
Endothelial precursor cells for enhancing and restoring vascular function
Patent Number: 7,135,171Numerous ways exist of augmenting angiogenesis. These range from administration of cytokines such as FGF (US Patent #6451303) to administration of cells (US Patent 5980887). The current patent teaches the administration of endothelial progenitor cells, not some much for...
Inventors: Edelberg; Jay (New York, NY), Rafii; Shahin (Great Neck, NY), Hong; Mun (New York, NY), Lanza; Robert P. (Clinton, MA), West; Michael D. (Southborough, MA)
Assignee: Cornell Research Foundation, Inc. (Ithaca, NY)
Date of First Priority Issue: Thursday August 9th, 2001
Bucky paper as a support membrane in retinal cell transplantation
Patent Number: 7,135,172Retinal degeneration is a major cause of blindness, percipitated by numerous conditions, including adult macular degeneration. While numerous companies are currently seeking ways of blocking angiogenesis and thereby blocking the retinal degeneration process, when this process has already occurred, there are no options for treatment. Intensive research is being carried out on ways of using stem...
Inventors: Loftus; David J. (Palo Alto, CA), Leng; Theodore (Mountain View, CA), Huie; Philip (Cupertino, CA), Fishman; Harvey (Menlo Park, CA)
Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, DC)
Date of First Priority Issue: Wednesday September 4th, 2002
1 Comment
1 Comment
Methods of use of FGF homologs
Patent Number: 7,135,459This patent covers the use of zFGF-5 (currently known as FGF-18) for expansion in vitro and in vivo of chondrocytes and neural stem cells. According to the Zymogenetics website, FGF-18 is out-licensed to Serono for use in cartilage repair and stroke. The product is in preclinical phases of testing. While the specification provides numerous uses for FGF-18, the claims are restricted to one...
Inventors: Deisher; Theresa A. (Seattle, WA), Conklin; Darrell C. (Seattle, WA)
Assignee: ZymoGenetics, Inc. (Seattle, WA)
Date of First Priority Issue: Monday October 16th, 2006
Method for neural stem cell differentiation using valproate
Patent Number: 7,132,286This patent covers the use of valproic acid for inducing differentiation of neurons from neural stem cells. This patent seems to be restricted in the claims to the in vitro differentiation of neurons. What is interesting is whether the concentrations claimed in the patent are actually achievable in vivo. Since valproic acid is clinically used as an anticonvulsant, it is interesting to...
Inventors: Laeng; Pascal (Washington, DC), Mallon; Barbara (Gaithersburg, MD), Pitts; Lee (Falls Church, VA)
Assignee: Psychiatric Genomics, Inc. (Gaithersburg, MD)
Date of First Priority Issue: Monday June 18th, 2001
Method for neural stem cell differentiation using 5HT-1A agonists
Patent Number: 7,132,287This patent teaches that culture of neuronal stem cells in the presence of an 5HT1A agonist (for example serotonin) will induce differentation into neurons.
Inventors: Rajan; Prithi (Rockville, MD), Altar; C. Anthony (Garrett Park, MD)
Assignee: Psychiatric Genomics, Inc. (Gaithersburg, MD)
Date of First Priority Issue: Monday June 18th, 2001
Differentiation of whole bone marrow
Patent Number: 7,129,034This patent teaches the generation of neurons from culturing of whole bone marrow in basic fibroblast growth factor and epidermal growth factor. This patent may be useful as a simple and easy to generate source of cells for therapy of neurodegenerative diseases.
Inventors: Yu; John S. (Los Angeles, CA), Kabos; Peter (Los Angeles, CA), Ehtesham; Moneeb (Nashville, TN)
Assignee: Cedars-Sinai Medical Center (Los Angeles, CA)
Date of First Priority Issue: Thursday October 25th, 2001