Patents
Method for remyelinating a demyelinized lesion due to injury in the brain or spinal cord
Patent Number: 7098027This patent is useful for inducing remyelination using autologous bone marrow stem cells. Demyelination is a pathology associated with numerous neuronal degenerative diseases such as multiple sclerosis or Krabbe Disease. The patent has 1 independent claim which covers the methodology of extracting bone marrow mononuclear cells from the autologous patient and injecting into the lesion of...
Inventors: Honmou, Osamu (Hokkaido, JP); Hashi, Kazuo (Hokkaido, JP); Uede, Teiji (Hokkaido, JP)
Assignee: Renomedix Institute, Inc. (Hokkaido, JP); Aska Pharmaceutical Co., Ltd. (Tokyo, JP); Mitsui Sumitomo Insurance Care Network Co., Ltd. (Tokyo, JP); Hitachi Ltd. (Tokyo, JP)
Date of First Priority Issue: Tuesday June 26th, 2001
Human desert hedgehog protein
Patent Number: 7098026This is a composition of matter patent covering the human desert hedgehog protein which is critically involved in various stages of development. The hedgehog proteins have applications in stem cell proliferation and differentiation. This patent is critical for anyone looking to use the desert hedgehog protein as a therapeutic. Potential areas of therapeutics include regeneration of epithelial...
Inventors: Ariyasu, Toshio (Okayama, JP); Nakamura, Shuji (Okayama, JP); Orita, Kunzo (Okayama, JP)
Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (Okayama, JP)
Date of First Priority Issue: Wednesday April 22nd, 1998
Selected cell delivery for heart failure
Patent Number: 7097833This patent is relevant for parties seeking to induce regeneration of cardiac tissue, or other tissue. Although the specification teaches the use of a variety of various peripheral blood and bone marrow stem cell sources for implantation into diseased, damaged, or otherwise subfunctional cardiac tissue, the issued claims only appear to cover the use of autologous, naturally residing cardiac...
Inventor: Freyman, Toby (Watertown, MA)
Assignee: Boston Scientific Scimed, Inc. (Maple Grove, MN)
Date of First Priority Issue: Friday July 19th, 2002
Intramyocardial injection of autologous bone marrow
Patent Number: 7097832This patent is useful for the induction of collateral blood vessel formation (for example angiogenesis) in ischemic tissue. There are numerous conditions that may benefit from induction of said collateral blood vessel formation. For example ischemia of the various organs may be treated using this patent. The patent overall teaches the use of autologous bone marrow cells, either ex vivo...
Inventors: Kornowski, Ran (Ramat hasharon, IL); Fuchs, Shmuel (Rockville, MD); Epstein, Stephen E. (Rockville, MD); Leon, Martin B. (New York, NY)
Assignee: Myocardial Therapeutics, Inc. (San Diego, CA)
Date of First Priority Issue: Tuesday March 30th, 1999
Growth factor which acts through erb b-4 rtk
Patent Number: 7094882This patent is useful for the manipulation of stem cell expansion through interfering with Neuregulin-4 signaling by antibody. Specifically, the patent has 2 independent claims that cover an antibody capable of binding to sequences which appear to be those of Neuregulin-4 or its active portions.
Inventors: Harari, Daniel (Rehovot, IL); Yarden, Yosef (Rehovot, IL)
Assignee: Yeda Research And Development Co. Ltd. (Rechovot, IL)
Date of First Priority Issue: Friday April 21st, 2000
Cationic lipid compositions targeting angiogenic endothelial cells
Patent Number: 7094424This patent teaches ways of selectively targeting a compound to endothelial cells. This could be used to administer stem cell stimulators in order to increase angiogenesis. The patent has one independent claim,that is "A method for selectively labeling angiogenic endothelial cells in vivo, the method comprising administering to a mammal a liposomal complex comprising cationic lipids and a...
Inventors: McDonald, Donald M. (San Francisco, CA); McLean, John (Redwood City, CA); Thurston, O. Gavin (San Francisco, CA); Baluk, Peter (San Francisco, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Date of First Priority Issue: Wednesday March 12th, 1997
Microinjection of cryoprotectants for preservation of cells
Patent Number: 7094601This patent is useful for cryopreservation of extremely sensitive cells such as oocytes and stem cells. Particularly, the patent deals with microinjection of various agents that protect cells during cryopreservation. The patent has 2 independent claims. The first covers the culture of oocytes (the concept that "culture" will be frozen) such that a cryopreservation agent is injected into...
Inventors: Toner, Mehmet (Wellesley, MA); Eroglu, Ali (Augusta, GA); Toth, Thomas (Sudbury, MA)
Assignee: The General Hospital Corporation (Boston, MA)
Date of First Priority Issue: Tuesday May 16th, 2000
Hair follicle growth factor proteins
Patent Number: 7094569This patent is useful for induction of hair growth through use of hair follicle growth factor (HFGF) proteins. Essentially, the HFGF proteins described in the application appear to be allelic variants of keratinocyte growth factor-2 (also known as FGF-10). There are both composition of matter, use, and delivery claims issued. One of the authors of the patent published a paper describing...
Inventors: Kim, Soogyun (Seoul, KR); Jang, Hyun-Jun (Seoul, KR
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Thursday May 24th, 2001
IL-3 variant hematopoiesis fusion protein
Patent Number: 7091319This patent covers fusion proteins of IL-3, that are useful for the growth, expansion, and in vivo expansion of stem cells. Although IL-3 and its fused partners are primarily important for hematopoietic stem cell expansion, the fusion proteins may have numerous other uses, including expanding hematopoietic-like stem cells that may be used for regenerative applications. The patent has numerous...
Inventors: Bauer, S. Christopher (New Haven, MO); Abrams, Mark Allen (St. Louis, MO); Braford-Goldberg, Sarah Ruth (St. Louis, MO); Caparon, Marie Helena (Chesterfield, MO); Easton, Alan Michael (Maryland Heights, MO); Klein, Barbara Kure (St. Louis, MO); McKearn, J
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday November 24th, 1992
Chemokine analogs for the treatment of human disease
Patent Number: 7,091,310This patent is useful for stem cell mobilization, stem cell homing, as well as a variety of other applications involving various chemokines. Specifically, the invention covers peptides that antagonize or agonize receptors for IL-8, IP-10, MIP-1 alpha., MCP-1, RANTES, I-309, and CCL28. IL-8 is known to be associated with inflammation and in terms of stem cells is known to be associated with...
Inventors: Merzouk, Ahmed (Richmond, CA); Wong, Donald (Vancouver, CA); Salari, Hassan (Delta, CA)
Assignee: Chemokine Therapeutics Corporation (Vancouver, CA)
Date of First Priority Issue: Friday September 13th, 2002