Patents
Modified hyaluronic acid for use in musculoskeletal tissue repair
Patent Number: 7091191This patent is useful for making scaffolds onto which stem cells, progenitor cells, or other type of cells can be seeded, and the scaffold together with the seeded cells are implanted in vivo. Previous scaffold technologies using hyaluronic acid have the drawback of very rapid resorption in the body, not giving the cells enough time to integrate and function properly. This patent uses a novel...
Inventors: Laredo, Walter R. (Hillsborough, NJ); Rezania, Alireza (Hillsborough, NJ)
Assignee: Ethicon, Inc. (Somerville, NJ)
Date of First Priority Issue: Friday December 19th, 2003
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Methods and compositions for screening for altered cellular phenotypes
Patent Number: 7056687This patent is useful for drug development. It teaches ways of inducing gene expression in cells (including stem cells) and using the specifically modified cells for screening of drug libraries. The invention itself is not specific to stem cells, so therefore we will not describe it in detail. The patent has 3 independent claims. Specifically: "A method of screening for cells having an...
Inventors: Lorens, James (Portola Valley, CA); Kinsella, Todd M. (Fayetteville, NC); Masuda, Esteban (Menlo Park, CA); Hitoshi, Yasumichi (Mountain View, CA); Liao, X. Charlene (Palo Alto, CA); Pearsall, Denise (Belmont, CA); Freiro, Annabelle (South San Francisco,
Assignee: Rigel Pharmaceuticals, Inc. (South San Francisco, CA)
Date of First Priority Issue: Tuesday May 12th, 1998
Cell culturing and storage systems, devices and methods
Patent Number: 7091035This invention is important for entities looking to expand various stem cells in vitro. The inventors noted that stem cells can differentiated into various types of other cells, and that a "dynamic" method of growing stem cells is relevant to what type of cells can be produced. The invention essentially covers ways of watching and manipulating stem cells and their progeny in culture as...
Inventors: Ravin, Rea (Rockville, MD); Sullivan, James V. (Bowie, MD); McKay, Ronald D. (Bethesda, MD)
Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC)
Date of First Priority Issue: Monday December 30th, 2002
Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof
Patent Number: 7078232Repair of articular cartilage is a substantial problem. The patent is useful for entities interested in providing a solution to this problem through the administration of cellular therapy containing adipose-derived stem cells in a biocompatible matrix or delivery system. The patent specifically has 4 independent claims. The first claim covers a composition of matter that is useful for treatment...
Inventors: Konkle, Jon (Durham, NC); Gimble, Jeffrey M. (Baton Rouge, LA)
Assignee: Artecel, Inc.
Date of First Priority Issue: Thursday August 19th, 1999
Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
Patent Number: 7078231This patent deals with the problem that the majority of pancreatic progenitor cells known at the time of filing are only capable of differentiating into islets but not other cells in the pancreas. Specifically, the patent cites patents 5,888,705 (Compositions and method of stimulating the proliferation and differentiation of human fetal and adult pancreatic cells ex vivo) and 5,834,308 (In vitro...
Inventors: Roberts, Penelope E (Millbrae, CA); Mather, Jennie Powell (Millbrae, CA)
Assignee: Raven biothechnologies, inc. (South San Francisco, CA)
Date of First Priority Issue: Wednesday October 4th, 2000
Adipose tissue-derived stromal cell that expresses characteristics of a neuronal cell
Patent Number: 7078230This patent is useful for entities interested in neurodegeneration and sources of neural-like cells. The patent is a composition of matter patent on adipose tissue derived cells that are endowed with neural characteristics. The patent has 2 independent claims, the first covers an adipose tissue derived stromal cell that is differentiated to express neuronal phenotypic markers. The second claim...
Inventors: Wilkison, William O. (Bahama, NC); Gimble, Jeffrey (Chapel Hill, NC)
Assignee: Artecel, Inc. (Baltimore, MD)
Date of First Priority Issue: Saturday February 26th, 2000
Method for enhancing proliferation or differentiation of a cell using ob protein
Patent Number: 7074397This patent is useful for treatment of neutropenias and other conditions where expansion of bone marrow is required. The patent teaches the use of WSX ligands in stimulation of hematopoiesis. One such ligand is leptin. The patent has 2 independent claims. The first covers enhancing proliferation or differentiation a cell of the hematopoietic lineage through administration of the OB protein...
Inventor: Matthews, William (Woodside, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Date of First Priority Issue: Thursday August 1st, 1996
Resorbable posterior spinal fusion system
Patent Number: 7074239This invention is useful for entities interested in inducing spinal fusion, primarily for patients with lower back pain. The invention covers a medical implant that can be used to deliver various stem cell and progenitor cell chemoattractants, as well as morphogens, in order to accelerate healing and efficient fusion of vertebrae.
Inventors: Cornwall, G. Bryan (San Diego, CA); Sohngen, Gary (San Pedro, CA); Lane, Joseph M. (New York, NY); Tomin, Emre A. (New York, NY)
Assignee: Cytori Therapeutics, Inc. (San Diego, CA)
Date of First Priority Issue: Wednesday April 25th, 2001
Production of cultured human mast cells and basophils for high throughput small molecule drug discovery
Patent Number: 7070996This is a patent covering the use of CD34+ generated mast cells for drug screening. Since technologies for generating mast cells existed in the prior art (for example, as early as 1991 it was known that CD34+ cells can differentiate into mast cells: Kirshenbaum AS, et al. Demonstration of the origin of human mast cells from CD34+ bone marrow progenitor cells. J Immunol. 1991 Mar 1;146(5):1410-5...
Inventor: Rossi, Alexander B. (San Francisco, CA)
Assignee: Rigel Pharmaceuticals, Inc. (South San Francisco, CA)
Date of First Priority Issue: Friday August 31st, 2001
Method for cloning animals with targetted genetic alterations by transfer of long-term cultured male or female somatic cell nuclei, comprising artificially-induced genetic alterations, to enucleated recipient cells
Patent Number: 7071372Although numerous technologies exist for cloning of animals, it appears from the current patent, that one of the limitations is that the donor cell usually has to be freshly isolated, or cultured for a short period of time. This does not allow for manipulation of the donor cell at a genetic level before nuclear transfer. The current patent teaches methods of long-term culture of donor cells so...
Inventors: Yang, Xiangzhong (Storrs, CT); Kubota, Chikara (Kagoshima, JP)
Assignee: University of Connecticut (Farmington, CT); The Governor of Kagoshima Prefecture (JP)
Date of First Priority Issue: Saturday April 1st, 2000