Patents
Methods of using immunophilin binding drugs to improve integration and survival of neuronal cell transplants
Patent Number: 7041283This patent teaches the use of immunophilin binding agents for culturing of neuronal cells so as to use for cellular therapy. The patent has 2 independent claims, both covering a method of treatment of a neurodegenerative illness by administration of cells that have been cultured with immunophilin binding agents. This patent is very interesting, not from the perspective of cell therapy per se...
Inventors: Achim, Cristian L. (Allison Park, PA); Avramut, Mihaela (Pittsburgh, PA); Zeevi, Adriana (Pittsburgh, PA)
Assignee: University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, PA)
Date of First Priority Issue: Friday February 16th, 2001
Hematopoietic stem cell proliferating agents
Patent Number: 7037892Stimulation of hematopoiesis in patients who are neutropenic after chemo, or radiation is a major goal of medicine. This is particularly important due to infectious disease complications that arise in patients that have been myeloablated. This patent teaches the use of insulin like growth factor as an adjuvant to several of the major stimulators of hematopoiesis that are already in the...
Inventors: Saito, Yoshimasa (Kawanishi, JP); Ueda, Yoshiko (Osaka, JP); Tamura, Kouichi (Kobe, JP); Takata, Yoko (Osaka, JP); Yamada, Hisashi (Sanda, JP); Yamashita, Tatsuo (Kobe, JP); Kobayashi, Masakazu (Takarazuka, JP)
Assignee: Astellas Pharma Inc. (Tokyo, JP)
Date of First Priority Issue: Monday December 8th, 1997
Neuroepithelial stem cells and glial-restricted intermediate precursors
Patent Number: 7037720This patent appears to cover a progenitor cell of neuronal lineage. Specifically the patent has 2 independent claims. The first covers a population of neuroepithelial stem cells derived from embryonic sources which are dependent of FGF for proliferation and can differentiate into CNS neuronal cells and CNS glial cells, The second covers a population restricted to the glial lineage but can...
Inventors: Rao, Mahendra S. (Salt Lake City, UT); Mayer-Proschel, Margot (Sandy, UT)
Assignee: University of Utah Reseach Foundation (Salt Lake City, UT)
Date of First Priority Issue: Saturday July 5th, 1997
Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
Patent Number: 7037719This patent teaches how to isolate neuronal stem cells from human fetal brain. The stem cells, or I guess more appropriately, "progenitor cells", are isolated based on positive expression of AC133, binding to the antibody 5E12 (don’t know what that is), and negative for CD34 and CD45. The patent has 6 independent claims which cover the population of CD34-, CD45-, AC133+, 5E12+ cells. In...
Inventors: Buck, David W. (Heathfield, GB); Uchida, Nobuko (Palo Alto, CA); Weissman, Irving (Redwood City, CA)
)
Assignee: StemCells California, Inc. (Palo Alto, CA
Date of First Priority Issue: Thursday December 2nd, 1999
Method of inducing neuronal production in the brain and spinal cord
Patent Number: 7037493This patent has 2 independent claims. The first covers a method of addition of medium spiny neurons in an adult brain through local lateral wall administration of a nucleotide expressing BDNF, as well as noggin. The second independent claim covers generation of medium spiny neurons in a patient with Huntington's disease. Medium spiny neurons are inhibitory neurons that comprise about 75% of the...
Inventors: Goldman, Steven A. (South Salem, NY); Benraiss, Abdellatif (Astoria, NY)
Assignee: Cornell Research Foundation, Inc. (Ithaca, NY)
Date of First Priority Issue: Wednesday January 5th, 2000
Islet cells from human embryonic stem cells
Patent Number: 7033831This patent covers a method of generating insulin producing cells from human embryonic stem cells through the process of first incubating the human embryonic stem cells with Activin A, and then subsequently incubating the cells with nicotinamide. Activin is a peptide involved in wound healing and morphogenesis, wherease nicotinamide is a type of vitamine B3 and improves beta cell functions...
Inventors: Fisk, Gregory J. (Fremont, CA); Inokuma, Margaret S. (San Jose, CA)
Assignee: Geron Corporation (Menlo Park, CA
Date of First Priority Issue: Thursday July 12th, 2001
Drug releasing biodegradable fiber for delivery of therapeutics
Patent Number: 7033603This patent relates to ways of delivering drugs (for example stem cell stimulating agents) to specific anatomical areas using an implantable, biodegradible approach. Specifically, the patent has 4 independent claims, the first 3 cover a delivery composition, and the 4th covers a scaffold.
Inventors: Nelson, Kevin D. (Arlington, TX); Crow, Brent B. (Fort Worth, TX)
Assignee: Board of Regents The University of Texas (Austin, TX)
Date of First Priority Issue: Tuesday June 8th, 1999
Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
Patent Number: 7033587This patent teaches ways to make artificial cartilage patches using adipose stem cells as starting material. These patches may be useful for people having injuries in which cartilage is damaged. The patent has 1 independent claim which essentially covers producing such an artifical patch through taking out adipose stem cells, culturing the cells to become chondrocytes, allowing the...
Inventors: Halvorsen, Yuan-Di C. (Holly Springs, NC); Wilkison, William O. (Bahama, NC); Gimble, Jeffrey Martin (Chapel Hill, NC)
Assignee: Artecel Sciences, Inc. (Durham, NC)
Date of First Priority Issue: Thursday August 19th, 1999
Deflectable microimplant delivery system
Patent Number: 7033345This invention covers a medical device that can be used for administration of a variety of drugs and/or cellular therapeutics. The patent essentially describes a "deflectable microimplant delivery system" that can be used for relatively non-invasive introduction of cells or agents into areas of need. The patent has numerous independent claims covering the various mechanical aspects of...
Inventors: Lee, Michael J. (Santa Rosa, CA); Kristoffersen, Kristian P. (Santa Rosa, CA)
Assignee: Advanced Cardiovascular Systems, Inc. (Santa Clara, CA)
Date of First Priority Issue: Tuesday May 21st, 2002
Method and system for myocardial infarction repair
Patent Number: 7031775This patent covers and implantable system made of cells, genes, other agents, together wtih a device that elecronically stimulates the cells. Specifically, the patent has 1 independent claim which covers a method of repairing the patient's myocardium through administration of a "cell repopulating source" and an "electrical stimulation device".
Inventors: Soykan, Orhan (Shoreview, MN); Donovan, Maura G. (St. Paul, MN)
Assignee: Medtronic, Inc. (Minneapolis, MN)
Date of First Priority Issue: Friday July 11th, 1997