Patents
Fibroblast growth factor and nucleic acids encoding same
Patent Number: 7056885The invention covers a novel type of fibroblast growth factor called FGF-CX, which is useful for differentiation and expansion of various stem cells. The patent has 2 independent claims: 1 for the composition of matter itself, and the second for the composition of matter together with a pharmaceutically applicable carrier.
Inventors: Jeffers, Michael (Branford, CT); Shimkets, Richard A. (West Haven, CT); Prayaga, Sudhirdas K. (East Haven, CT); Boldog, Ferenc L. (North Haven, CT); Yang, Meijia (East Lyme, CT); Burgess, Catherine (Wethersfield, CT); Fernandes, Elma (Branford, CT); Herrm
Assignee: CuraGen Corporation (Branford, CT)
Date of First Priority Issue: Tuesday July 27th, 1999
Early stage multipotential stem cells in colonies of bone marrow stromal cells
Patent Number: 7056738This is a composition of matter patent on a type of bone marrow derived stem cell. The authors state that marrow stromal cells (MSCS) are adult stem cells from bone marrow that can differentiate into multiple non-hematopoietic cell lineages. The authors identified that colonies of human MSCs contain both small, rapidly self-renewing stem cells (RS cells) and large, more mature cells (mMSCs...
Inventors: Prockop, Darwin J. (New Orleans, LA); Colter, David C. (Philadelphia, PA); Sekiya, Ichiro (New Orleans, LA)
Assignee: Tulane University (New Orleans, LA); Philadelphia Heath and Education Corporation (Philadelphia, PA)
Date of First Priority Issue: Friday March 23rd, 2001
Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or exendin-4 and uses thereof
Patent Number: 7056734This patent is useful for entities seeking to treat diabetes or other pancreatic abnormalities. The patent has very broad claims, all centered around the ability of GLP and Exendin-4 to induce differentiation of cells into insulin produce or amylase producing cells. The patent has 8 independent claims. The first four claims are directed towards use of GLP-1 or related molecules to make either...
Inventors: Egan, Josephine (Baltimore, MD); Perfetti, Riccardo (Washington, DC); Passaniti, Antonino (White Hall, MD); Greig, Nigel (Silver Spring, MD); Holloway, Harold (Middle River, MD); Habener, Joel (Newton Centre, MA); Stoffers, Doris (Moorestown, NJ)
Assignee: The United States of America as represented by the Department of Health and Human Services, NIH
Date of First Priority Issue: Friday October 8th, 1999
Nuclear reprogramming using IWSI and related chromatin remodeling ATPases
Patent Number: 7053264This patent is useful for parties seeking to perform cloning or generate stem cells through cloning. During nuclear transfer mediated cloning, one of the difficulties is that the donor nucleus has DNA packed tightly into chromatin. During usual nuclear transfer it is the role of the recipient oocyte to unravel the DNA and to perform the necessary "cleaning of the slate" so that the...
Inventors: Wolffe, legal representative, Elizabeth (Orinda, CA); Wolffe, deceased, Alan P. (Orinda, CA)
Assignee: Sangamo Biosciences, Inc. (Richmond, CA)
Date of First Priority Issue: Thursday September 28th, 2000
Preventives/remedies for proliferative organ diseases chronic arthritic diseases, hypertrophic scar or keloid
Patent Number: 7053050This patent is useful for treatment of proliferative diseases, including cancer. It is known that erythropoietin has functions on numerous stem cells in addition to hematopoietic ones. In this patent the inventors demonstrated that inhibition of EPO receptor signalling can have a useful anti-proliferative effect. The 2 independent claims cover use of the receptor antagonist and use of the...
Inventors: Yasuda, Yoshiko (Kyoto, JP); Nakamura, Yukio (Higashimurayama, JP); Fujita, Yoshihiko (Sakai, JP)
Assignee: Yoshiko Yasuda (Kyoto, JP)
Date of First Priority Issue: Sunday February 11th, 2001
Adult human dental pulp stem cells in vitro and in vivo
Patent Number: 7052907This patent covers a new type of stem cell derived from the dental pulp, it is useful for entities seeking to generate articial teeth, or dendin/pulp tissue. However, given that the patent actually claims a tooth stem cell, it may also be considered a composition of matter patent (although phenotype is somewhat ill defined in the claims). The patent has 3 independent claims. The first covers...
Inventors: Shi, Songtao (Gaithersburg, MD); Gronthos, Stan (Rockville, MD); Robey, Pamela Gehron (Bethesda, MD)
Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC)
Date of First Priority Issue: Friday July 21st, 2000
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Resorbable structure for treating and healing of tissue defects
Patent Number: 7049348Porous medical implants are covered by this patent that can be used to administer either stem cells, stem cell activating compositions of matter, or also just administered directly to allow for tissue re-growth on an injured area. The patent has one independent claim that covers the "porous polymeric device". The assignee, Kensey Nash corporation has a variety of implants/medical...
Inventors: Evans, Douglas G (Downingtown, PA); Kelly, Jeffrey C (Wilmington, DE); DeWitt, Todd M (Pottstown, PA)
Assignee: Kensey Nash Corporation (Exton, PA)
Date of First Priority Issue: Friday June 7th, 2002
Use of collagenase in the preparation of neural stem cell cultures
Patent Number: 7049141When growing neural stem cell cultures, at a certain point in culture they need to be passaged. According to the background in the patent, before the invention, scientists would dissociate neurospheres by mechanical means, which as one could expect causes a loss in cell viability. This patent covers the use of collagenase in dissociating neurospheres when passaging them. This patent is...
Inventor: Uchida, Nobuko (Palo Alto, CA)
Assignee: StemCells California, Inc. (Palo Alto, CA)
Date of First Priority Issue: Friday February 26th, 1999
Method for growth of human conjunctival tissue equivalents for research, clinical ocular surface transplantation and tissue engineering
Patent Number: 7049139There are two types of stem cells associated with the outside part of the eye…the limbal stem cells and the conjunctival stem cells. This patent teaches ways of culturing conjunctival stem cells, using various ex vivo tissue culture scenarious, including specialized culture conditions. There is one independent claim, which covers the basic aspects of these conditions. The patent is useful for...
Inventors: Tan, Donald (Singapore, SG); Ang, Leonard (Singapore, SG); Beuerman, Roger (New Orleans, LA)
Assignee: Singapore Eye Research Institute (Singapore, SG)
Date of First Priority Issue: Friday March 29th, 2002
Tissue engineered uterus
Patent Number: 7049057This invention teaches methods of generating an in vitro uterus using various scaffolds and cell compositions. The patent has 1 independent claim which covers a multilayered implantable uterus comprising of a biologically compatible matrix holding together uterine epithelial cell population that are attached to smooth muscle cell populations. This is an artificial organ patent, from the same...
Inventors: Atala, Anthony (Weston, MA); Yoo, James J. (Brookline, MA)
Assignee: Children's Medical Center Corporation (Boston, MA)
Date of First Priority Issue: Saturday November 16th, 2002