Patents
Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state
Patent Number: 7049072It is known from the literature that the non-tumor stroma surrounding the tumor plays an important role in the growth of the tumor by facilitating angiogenesis, providing growth factors, etc. In hematological malignancies, the fact that donor-derived leukemic relapse occurs in some individuals suggests that stromal elements may be responsible, or associated with leukemic transformation. This...
Inventor: Seshi, Beerelli (Torrance, CA)
Assignee: University of South Florida (Tampa, unknown)
Date of First Priority Issue: Monday June 5th, 2000
Combined regulation of neural cell production
Patent Number: 7048934This patent teaches ways of treating neurological disease such as Alzheimer's disease, multiple sclerosis (MS), Huntington's disease, amyotrophic lateral sclerosis, and Parkinson's disease through administration of several compounds that are already in the clinic such as prolactin and EPO. The patent applies to selectively producing neural cells, including neurons or glial cells (cells that...
Inventors: Thompson, Bradley G. (Calgary, CA); Weiss, Samuel (Calgary, CA); Shingo, Tetsuro (Aoe, JP)
Assignee: Stem Cell Therapeutics Inc. (Calgary, unknown)
Date of First Priority Issue: Thursday August 30th, 2001
Stimulation of hematopoiesis by ex vivo activated immune cells
Patent Number: 7048922This patent covers a clinically applicable method of increasing hematopoiesis through administration of activated peripheral blood mononuclear cells. The ability of these cells to secrete hematopoietic stimulatory cytokines is well established, however the inventor is actually claiming a method of using such ex vivo activated cells for treatment of a patient. The patent has 1 independent claim...
Inventor: Yang, Demao (Mountain View, CA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Wednesday May 29th, 2002
Neural transplantation using pluripotent neuroepithelial cells
Patent Number: 7048921This patent covers ways of treating neurological deficiencies or damage through transplantation of specific types of stem cells, or progenitor cells. Specifically, the patent has 3 independent claims. The first independent claim covers the intracerebrally transplantation of pluripotent, nestin-positive, neuroepithelial cells that have been conditionally immortalized through genetic manipulation...
Inventors: Sinden, John (London, GB); Gray, Jeffrey A. (London, GB); Hodges, Helen (London, GB); Kershaw, Timothy (London, GB); Rashid-Doubell, Fiza (Oxford, GB)
Assignee: ReNeuron Limited (GB)
Date of First Priority Issue: Saturday December 9th, 1995
Directed differentiation of human embryonic cells
Patent Number: 7045353This is basically the patent that covers how to generate neurons from embryonic stem cells. Of course the various composition of matter patents on embryonic stem cells (5,843,780, 6,200,806, 7,029,913) have to be in-licensed to use this invention. The invention has one broad independent claim which covers a method of differentiating human embryonic stem cells into neurons. The method basically...
Inventor: Benvenisty, Nissim (Jerusalem, IL)
Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem (Jerusalem, IL)
Date of First Priority Issue: Saturday January 8th, 2000
Method of collecting placental stem cells
Patent Number: 7045148This patent is useful for entities seeking to extract additional CD34 stem cells from placenta than can be normally gathered by just letting the blood drip and collecting cord blood. This patent has one independent claim that covers, essentially perfusing the placenta with an anticoagulated solution after the cord blood has dripped out.
Inventor: Hariri, Robert J. (Florham Park, NJ)
Assignee: Anthrogenesis Corporation (Cedar Knolls, NJ)
Date of First Priority Issue: Monday June 12th, 2000
Therapeutic cellular stent
Patent Number: 7044965This patent covers a type of stent that contains cells and is useful not only for maintaining open a blood vessel, but also for delivery of cells that secrete various agents useful for the body. The patent has two independent claims, the first covering a stent containing cells, the second covering a method of administering cells into an organism. Stents have been covered with many agents in...
Inventor: Spielberg, Theodore E. (Wellesley, MA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday December 13th, 2002
Transdiffentiation of transfected epidermal basal cells into neural progenitor cells, neuronal cells and/or glial cells
Patent Number: 7041507This invention teaches how to generate neurons from skin. Essentially, the inventors found that through the process of isolating epidermal stem cells (basal cells), transfected said basal cells with genes encoding neurogenic transcription factors, suppressing transcription factors that maintain a differentiated phenotype (by for example antisense), and then culturing the cells with exogenous...
Inventors: Levesque, Michel F. (Beverly Hills, CA); Neuman, Toomas (Santa Monica, CA)
Assignee: Cedars-Sinai Medical Center (Los Angeles, CA)
Date of First Priority Issue: Wednesday January 20th, 1999
Use of human embryonic stem cells for drug screening and toxicity testing
Patent Number: 7041438This is a very broad patent that essentially covers all drug screening using a specific type of stem cells. The inventors describe these stem cells as "primate Pluripotent Stem cells" (pPS cells), thus including pre-embryonic, embryonic, or fetal tissue-derived cells that can be induced to differentiated into progeny of the three germinal layers: endoderm, mesoderm, and ectoderm. This of...
Inventors: Carpenter, Melissa K. (London, CA); Inokuma, Margaret S. (San Jose, CA); Xu, Chunhui (Palo Alto, CA)
Assignee: Geron Corporation (Menlo Park, CA)
Date of First Priority Issue: Thursday June 22nd, 2000
Spinal fusion using an HMG-CoA reductase inhibitor
Patent Number: 7041309HMG-CoA reductase inhibitors ("Statins" for the purpose of our discussion) have been known to increase endothelial stem cell mobilization, as well as possess other interesting functions such as suppressing disease in the mouse model of multiple sclerosis. In this patent, the use of statins for promoting spinal fusion is thought. Specifically, the patent claims that it is not anticipated...
Inventors: Remington, Benjamin J. (Modesto, CA); Bearss, David J. (Tucson, AZ); Shahi, Kavian (Granite Bay, CA)
Assignee: NeuroPro Technologies, Inc. (Modesto, CA)
Date of First Priority Issue: Monday May 13th, 2002