News Posts
Oocytes from ES cells
Beijing, China - The generation of oocyte-like cells from embryonic stem cells is described in the current paper (Qing et al. Induction of oocyte-like cells from mouse embryonic stem cells by co-culture with ovarian granulosa cells. Differentiation. 2007 May 9). Following the previous example of neural coculture stimulatingEndotoxin decreases circulating EPC
Vienna, Austria - Circulating endothelial progenitor cell levels have been reported to increase with exercise, smoking cessation, as well as taking statin drugs...amongst other things. In a recent paper it was demonstrated that endotoxin induces a temporary (24 hr) decrease in the number of circulating endothelial progenitors (Mayr et al. Effects of low dose endotoxemia on endothelial...Monday May 14th, 2007 @ 14:32:08 EST
Pluripotency in the amnion
Pittsburgh, PA - It has previously been described that anmiotic stem cells can be isolated and contain numerous regenerative properties. In a recent paper (Miki et al. Identification of stem cell marker-positive cells by immunofluorescence in term human amnion. J Reprod Immunol. 2007 May 8) the characterization of stem cells from...Monday May 14th, 2007 @ 14:20:32 EST
HIF involved in mesenchymal to neural differentiation
Caen cedex, France - The identification of molecular signals associated with cellular differentiation is important from a drug development perspective. Recently, a paper was published describing mechanisms of mesenchymal stem cell differentiation to neural cells (Pacary et al. Crosstalk between HIF-1 and ROCK pathways in neuronal differentiation of mesenchymal stem cells, neurospheres and in...Monday May 14th, 2007 @ 14:07:36 EST
Coaxing ES cells to neurons
Hong Kong, China - Numerous groups are currently working on protocols for induction of differentiation of embryonic stem cells into specific cell types that are therapeutically useful. One logical method of stimulating differentiation involves co-culture with cells that would appear to have an "inductive" effect on the undifferentiated cell. On the one hand, numerous groups use methods such...Sunday May 13th, 2007 @ 19:30:36 EST
Suppressor Stem Cells
Baltimore, Maryland - In the late 1960s to early 1970s, a type of immune regulatory cell called the "natural suppressor" cell was believed to exist associated with areas of hematopoiesis. Subsequent characterization of these cells revealed that they actually possess myelopoietic properties and inhibited immunity through secretion of factors such as TGF-beta and Reptimed. In a recent...Tuesday May 8th, 2007 @ 10:20:30 EST
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bcl-2 tx: Long Live Mesenchymal Stem Cells
Rostock, Germany - Anti-inflammatory and regenerative abilities of mesenchymal stem cells are well-known. In fact, the first non-hematopoietic clinically approved use of stem cells is most likely to occur with Osiris's mesenchymal stem cell products which are in Phase III of clinical trials. The important question scientists have to ask themselves is what is the next stem in stem cell...Saturday May 5th, 2007 @ 10:42:04 EST
HSP antiinflammatory
San Francisco, California - Heat shock proteins are conventionally thought of as molecular chaperones that function intracellularly. Immunologically, heat shock proteins are known to bind various tumor antigens and can be used as adjuvants. The properties of adjuvants include non-specific activation of innate immunity. It was found that various heat shock proteins stimulate macrophage and...Friday May 4th, 2007 @ 18:10:37 EST
Cord Blood To Skin
Nanchang, China - The use of stem cells for burn injury is attractive not only for repairing injured tissue directly and through trophic factor secretion, but also by their potential to inhibit inflammatory responses. In a recent paper (Dai et al. Skin epithelial cells in mice from umbilical cord blood mesenchymal stem cells. Burns. 2007 Apr 26) cord blood mesenchymal stem cells were...Wednesday May 2nd, 2007 @ 11:34:16 EST
Neural proliferation after injury
Miami, Florida - Although it is reported that the brain can repair itself after injury, detailed examination of this is still somewhat lacking. In a nicely designed study (Urrea et al. Widespread cellular proliferation and focal neurogenesis after traumatic brain injury in the rat. Restor Neurol Neurosci. 2007;25(1):65-77), proliferation of various brain areas was assessed following...Tuesday May 1st, 2007 @ 15:45:44 EST