Class: Expansion (424)
Growth and differentiation of adult muscle stem cells with activators or inhibitors of Wnt signaling
Patent Number: 7,541,183Depending on extent of injury, bone marrow derived stem cells are known to mobilize and migrate in order to accelerate healing. This has been demonstrated in conditions such as heart attack, stroke, and in critical limb ischemia after administration of exogenous stem cells.
Various parts of...
Enhanced growth of adult stem cells with Dkk-1
Patent Number: 7,485,460Although mesenchymal stem cells, or mesenchymal stromal cells (as some others call them), are in late stages of clinical development, there is still room for optimizing their therapeutic effects.
For example, various groups have transfected MSC with genes such as nanog or bcl-2 or
Wound and cutaneous injury healing with a nucleic acid encoding perlecan
Patent Number: 7,141,551Perlecan is a proteoglycan (A molecule that contains both protein and glycosaminoglycans, which are a type of polysaccharide) that is found in the basement membrane. Upregulation of perlecan expression is observed during wound healing, as well as VEGF-mediated tumor angiogenesis. It is known that perlcan binds to numerous growth factors including
Compositions for controlling hair growth
Patent Number: 7,223,562This patent covers a novel protein called follicular papilla-1 (FP-1), that is selectively expressed in follicular papilla but not in dermal fibroblasts. The patent covers the FP-1 composition of matter, as well as vectors expressing it, cells expressing it, and specific sequences. FP-1 is essential for hair growth has demonstrated by siRNA and antibody inhibition experiments. Additionally...
Compositions, methods and kits related to thrombin, Notch signaling and stamatogenesis and growth of stem cells
Patent Number: 7,501,281This patent covers means of generating pluripotent stem cells out of neural stem cells or neural crest stem cells. This is accomplished through contacting the neural stem cell or neural crest stem cell with an agent chosen from the following: a) thrombin; b) soluble Jagged1; c) thrombin receptor activated peptide, or d) a combination.
It appears the inventors discovered that various...
Method for treatment of depression
Patent Number: 7,309,348The use of various types of energies to manipulate stem cells or to modulate the specific niche in which stem cells are placed is an exciting area of development. Photothera is a San Diego based company that has been clinically developing an area called "photoceuticals" for the past several years, primarily in relation to...
Composition and method for culturing potentially regenerative cells and functional tissue-organs in vitro
Patent Number: 6972195This patent teaches the composition of a culture media that is shown in the EXAMPLES section useful for growing: Human Intestinal Cells, Mouse Intestinal Mucosal Villi, Mouse Bone Marrow Tissue , Rat Nerve Tissue, Mouse Pancreatic Cells, Mouse Renal Cells, Human Hair Follicles, Rat Cardiomuscular Cells, Rat Thymocytes , and Rat Hepatocytes. The examples also show...
Cell culturing and storage systems, devices and methods
Patent Number: 7091035This invention is important for entities looking to expand various stem cells in vitro. The inventors noted that stem cells can differentiated into various types of other cells, and that a "dynamic" method of growing stem cells is relevant to what type of cells can be produced. The invention essentially covers ways of watching and manipulating stem cells and their progeny in culture as...
Cultured cells from pancreatic islets
Patent Number: 7,157,278The possibility of ex vivo expansion of islets has been a goal of cell therapy researchers for decades. This patent teaches methods of isolating beta precursor cells from pancreatic islets, expansion ex vivo through culture in serum-free growth factors, and the possible use for replacement therapy in diabetics. Identification of islet precursors is performed by assessment of nestin and pdx1...
Compounds and methods for increasing neurogenesis
Patent Number: 6969702This patent deals with administration of compounds, some which I believe are already in the clinic, for stimulation of neurogenesis in a patient suffering from a neurodegenerative condition. The patent has 2 independent claims, the first covers the administration of calcitonin, or exendin or analogues thereof that intracellular cAMP levels. The second independent claim covers administration...
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