Class: Expansion (424)
Telomere-encoding synthetic DNA nanocircles, and their use for the elongation of telomere repeats
Patent Number: 7,482,332Telomeres are repeats of the TTAGGG sequence on the ends of chromosomes that progressively get shorter with each cell division, causing eventual cell senescence. The enzyme telomerase is important in cells that need to proliferate longer, for example memory T cells, or stem cells. It is a dream of many to induce telomerase activity in cells so as to be...
Methods of promoting the growth or differentiation of hematopoietic stem or progenitor cells by non-muscle type cofilin
Patent Number: 7,282,201One of the biggest payoffs in biotechnology has been development of therapeutics that modulate the hematopoietic stem cells. For example, agents such as EPO or G-CSF have become block-buster drugs for stimulation of erythropoiesis or granulopoiesis respectively. The current patent teaches a new way to stimulate hematopoiesis through administration of cofilin and...
Cultured skin and method of manufacturing the same
Patent Number: 6916655This patent is useful for generation of skin cells and skin-like cells from umbilical cords. Since cord blood is extracted from the cord and the cord is usually disposed of, this patent may be of particular importance. The only disadvantage of this patent is that its 1 issued claim seems to cover only a certain method of culturing the cells in a specific media. A method of culturing...
Neuroprotection and neuroegenisis by administering cyclic prolyl glycine
Patent Number: 7,232,798This invention relates to the discovery of the functions of cyclic Propyl Glycine as a novel antagonist that either blocks the AMPA and/or the NMDA receptors. Since agonism of these receptors is associated with excitotoxic neuronal death, the invention covers the use of cyclic propyl glycine as a neuroprotectant in a variety of settings...
Methods and compositions for the diagnosis and treatment of hematological disorders using 2777
Patent Number: 6953778This patent is a demonstration of creative patent writing, with positive results of claim issuance. Essentially, the inventors found a novel gene called 2777 which is significantly expressed in erythroid cells both in vitro and in vivo. 2777 is also expressed in erythroid progenitor (BFU-E) cells and Glycophorin A positive-lo (GPA-lo) cells in vivo. Since 2777 appears at a structural level to...
Method for enhancing keratinocyte stem cells
Patent Number: 7,476,538This patent covers methods of selecting keratinocyte stem cells and expanding them. As you can imagine, one of the major applications for keratinocyte stem cells is in the cosmetics area (assignee is L'Oreal).
The patent covers A method for enriching keratinocyte stem cells (KSCs) from a sample of keratinocytes and KSCs, said KSCs having an expansion potential of at least 10.sup.9...
Methods of using deacetylase inhibitors to promote cell differentiation and regeneration
Patent Number: 7,229,963The use of histone deacetylase inhibitors for inducing new gene expression of genes that are developmentally silenced is a very exciting method of "reactivating" stem cells. For example, the histone deacetylase inhibitor valproic acid is a clinically used agent that stimulates stem cell expansion. The current patent teaches...
Prolactin induced increase in neural stem cell numbers
Patent Number: 7,393,830We at StemCellPatents.com believe that the future of stem cell therapy will involve optimization of current therapeutic approaches that are already in clinical trials. For example, it is known that intravenous administration of mesenchymal stem cells can generate statistically significant improvement in heart function after heart attacks. It is also...
Culture system for rapid expansion of human embryonic stem cells
Patent Number: 7,410,798This patent covers methods of expanding embryonic stem cells in vitro in large quantities without inducing their differentiation. Essentially the method covered is represented by the first independent claim which discloses the culture system which contains an extracellular matrix, a non-conditioned medium, and 40 nanograms per ml of FGF. The claim also states that the culture is...
Combined regulation of neural cell production
Patent Number: 7048934This patent teaches ways of treating neurological disease such as Alzheimer's disease, multiple sclerosis (MS), Huntington's disease, amyotrophic lateral sclerosis, and Parkinson's disease through administration of several compounds that are already in the clinic such as prolactin and EPO. The patent applies to selectively producing neural cells, including neurons...