Class: Expansion (424)
Compounds modulating c-kit activity
Patent Number: 7,498,342c-kit is involved in hematopoietic stem cell self-renewal, however it is also found in other stem cells as well. For example, cardiac stem cells express c-kit. This is an exciting drug target and other companies have patents covering its inhibitors, for example, #7,211,600 by Sugen.
The current patent covers...
Feeder independent extended culture of embryonic stem cells
Patent Number: 7,514,260This patent covers methods of expanding embryonic stem cells without inducing their differentiation. It specifically teaches feeder-free systems so that exogenous cells do not need to be used.
It gets away without needing a feeder by providing 2 cytokines:noggin, and a fibroblast growth factor family member, as well as various nutrients.
The first independent claim...
Method of treating mood disorders and/or anxiety disorders by brain stimulation
Patent Number: 7,313,442While studies have already demonstrated the ability of adult stem cells and embryonic stem cells to differentiate into neurons, the possibility of modulating new neurons to integrate into existing neurons, as well as enhance activity, is the philosophical "next...
Method of expanding and differentiating cord blood cells by hyperthermic incubation
Patent Number: 7,452,662The stem cell compartment is part of a physiological system that responds to various stimuli. For example, during infections, the hematopoietic stem cells produce more granulocytes to fight off the sickness, or during periods of hypoxia (such as living on a mountain), they produce more erythrocytes. Inventors have used the physiological context of stem cells to come up with new...
Use of Xenopus laevis oocytes a microincubators
Patent Number: 7,135,336The concept of "de-differentiation" of cells is very attractive from a therapeutic perspective since it offers the possibility of generating autologous stem cells from somatic tissue. If one could devise a method for generating even minute numbers of totipotent stem cells from autologous tissue, these cells could be expanded and used to treat almost any illness. The use...
Aryl-containing 5-acylindolinones, the preparation thereof and their use as medicaments
Patent Number: 7,176,231Although much effort in stem cell therapeutic development is being focused on administration of exogenous stem cells, one area that is generally being overlooked is methods of activating/expanding endogenous stem cells. It was recently published that the in vivo inhibition of the enzyme GSK-3 promotes hematopoietic stem cell self renewal (Trowbridge et al. Glycogen...
Method for enhancing proliferation of bone marrow cells or spleen cells with an ethanol-insoluble extract of dioscorea
Patent Number: 7,419,690There has been a great interest in patenting natural compounds and plant derivatives for manipulation of the stem cell compartment. For example, there is an issued patent covering seaweed extract for mobilization of stem cells, pine cone extracts for dendritic cell differentiation, and now the use of Yam extracts for...
Nutritional composition against side effects of chemotherapy or radiotherapy
Patent Number: 7,468,193We at StemCellPatents.com have been seeing an increasing interest in "nutritional" modulation of the stem cell compartment. For example, patent # 7,338,676 teaches the use pine cone extracts for inducing differentiation of progenitor cells to dendritic cells. Patent # 6,814,961 covers the composition of...
Method to enhance hematopoiesis
Patent Number: 7,196,060This patent teaches the use of a composition of matter called T-4 immune stimulating factor (TISF). This peptide was patented previously as a 50 kDa molecule in US patent # 5,616,554 as being useful for stimulation of CD4 T cell responses. The composition is derived from thymic cell lines and appears to be primarily immunostimulatory. In the current patent the use...
Amino thiol compounds and compositions for use in conjunction with cancer therapy
Patent Number: 7,314,959One of the important areas of drug development is protecting stem cells and healthy tissue from the damaging effects of cytotoxic chemotherapy and radiation therapy. In fact, a "stem cell therapy" that has become a multi-billion dollar product is the use of G-CSF to stimulate hematopoietic recovery after cancer therapy or bone marrow transplantation. In fact, numerous patents have been...