Class: Expansion (424)
Telomerase reverse transcriptase fragments and uses thereof
Patent Number: 7,294,708Telomerase reverse transcriptase is an enzyme that transcribes the telomerase RNA component into telomeric DNA in order to replenish telomeric loss associated with cellular proliferation. The activity of telomerase is absent in most adult cells with the exception of stem cells and tumor cells. Accordingly, one possible method of blocking tumor...
Compositions and treatments for myelosuppression by ex vivo activated immune cells
Patent Number: 7,332,158Failure/suppression of the hematopoietic can be a deadly consequence of over-aggressive administration of chemotherapeutics/radiotherapy. The global market for agents that stimulate hematopoiesis, particularly granulopoiesis is in the billions of dollars per year, as witnessed by the success of Amgen’s Neuopgen and Neulasta products. The current patent teaches a novel, and arguably more...
Stimulation of hematopoiesis by ex vivo activated immune cells
Patent Number: 7048922This patent covers a clinically applicable method of increasing hematopoiesis through administration of activated peripheral blood mononuclear cells. The ability of these cells to secrete hematopoietic stimulatory cytokines is well established, however the inventor is actually claiming a method of using such ex vivo activated cells for treatment of a patient. The patent has 1 independent...
Spinal fusion using an HMG-CoA reductase inhibitor
Patent Number: 7041309HMG-CoA reductase inhibitors ("Statins" for the purpose of our discussion) have been known to increase endothelial stem cell mobilization, as well as possess other interesting functions such as suppressing disease in the mouse model of multiple sclerosis. In this patent, the use of statins for promoting spinal fusion is thought. Specifically, the patent...
Polypeptide having an activity to support proliferation or survival of hematopoietic stem or progenitor cells
Patent Number: 7,439,332This patent covers a specific nucleic acid sequence and expressed protein thereof, for the stimulation of erythropoiesis.
The inventors identified the protein through establishing stromal cell lines from the AGM (Aorta-Gonad-Mesonephros) region of a fetal mouse and screening them to see which ones support hematopoiesis, and which type of hematopoietic propensity (eg were they...
Method of stimulating stem cells
Patent Number: 7,524,500Methods of expanding stem cells are well-known in the art. For example, #7,423,029 teaches the use of heterocyclic trialkyl ammonium-containing compounds for stimulation of bone marrow stem cells. #7,135,459 covers use of FGF homologues for expansion of neural and chondrocytic stem cells. #
Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
Patent Number: 7,344,881This patent covers methods of expanding hematopoietic stem cells and their progenitors. The methods induce expansion but not differentiation of the cells. Essentially the patent teachs that expansion can be achieved by culture in media containing an "effective amount of TEPA-Cu chelate". TEPA stands for tetraethylenepentamine...
Serum-free media for chondrocytes and methods of use thereof
Patent Number: 7,169,610This patent discloses methods of expanding chondrocyte precursors and differentiated chondrocytes ex vivo without the use of animal derived tissue culture components. The patent teaches the use of growth factors such as platelet derived growth factor, together with specific lipids, such as stearic acid, myristic acid, oleic acid, linoleic acid, palmitic acid, palmitoleic acid...
Cytokine zcytor17 ligand
Patent Number: 7064186This is a composition of matter patent covering the cytokine zcytor17 ligand, which is involved in various immune and stem cell activities. The patent has 3 independent claims, all covering composition of matter. The email of the senior author is dillons@zgi.com
Human hematopoietic growth regulatory gene and uses
Patent Number: 6900017HIWI is the human homologue of PIWI a gene found in fruitfly embryonic germline stem cells. HIWI is found in CD34 hematopoietic cells and appears to act as a negative regulator in that its transfection causes apoptosis in hematopoietic cell lines (Sharma AK...