Class: Expansion (424)
Protection of cardiac myocardium
Patent Number: 7,504,379This patent has two sets of independent claims. The first covers "method of increasing survival of blood vessels" and the second "method of reducing myocardial necrosis".
Both of these aims are achieved by "administering to the patient a therapeutically effective amount of platelet derived growth factor, angiopoietin-2, and vascular endothelial growth...
Methods for promoting wound healing
Patent Number: 7,189,746The stimulation of healing processes after injury involves a neurological component. The inventors of the patent clearly demonstrate through several prior art examples that wound repair requires innervation of the peripheral tissue, and that damage to the surrounding nerves results in inhibition of wound repair.
For example, the inventor describes a paper (Huang et al. Influence of... Human embryonic stem cells were classically grown on mouse feeder layers. Unfortunately these cells can not be clinically used since numerous adventitious viruses and infectious agents exist that theoretically can infect humans.
The current patent teaches the use of human foreskin fibroblasts as feeder layers for growing embryonic stem cells. Foreskin fibroblasts are conventionally... This patent covers a screening system for assaying small molecule libraries for telomerase stimulating activity. Specifically, the inventors have found that telomerase reverse transcriptase (TERT) activity can be modulated by agents that alter the binding interaction of the GC-Box 5 repressor site with a repressor protein (or protein complex including the same). Using this system the... The use of hematopoietic stem cells for numerous conditions has been around for decades, originally of course in the form of allogeneic bone marrow transplant, and more recently various variations such as autologous transplantation, autologous transplantation and purging, and autologous transplantation for non-hematopoietic conditions such as cardiac infarction. One of the limiting... This patent is useful for expansion and maintaining mesenchymal stem cells through the uniquely discovered property of cord blood serum to be able to substitute for other sources of serum such as fetal calf serum. The patent has 3 independent claims. The first is directed towards growing mesenchymal stem cells, and the second at third are directed towards isolating mesenchymal stem cells by... This patent covers the composition of matter for a small molecule inhibitor of p38 MAP kinase, as well as the use of these compounds for stimulation/acceleration of bone healing. Presumably since p38 is involved in inflammatory signaling, the inhibition of this pathway allows for regenerative activities to prevail, thus allowing healing unimpeded by inflammation... Embryonic stem cells generally require feeder cells to grow on. Traditionally, mouse feeder layers where used, for example in the early work when human embryonic stem cells were patented. The importance of the feeder layer is to provide the right environment for the embryonic stem cells to be capable of proliferating without spontaneously... Pharmaceutical activation of stem cells is arguably the next major revolution in medicine. The current patent is assigned to a Canadian stem cell company, Stem Cell Therapeutics (TSX-V:SSS), which already has entered Phase II clinical trials with pharmaceutical activators of endogenous stem cells for the treatment of stroke. While the ongoing clinical work of Stem Cell Therapeutics involves... This patent covers an "activated yeast" preparation that is useful for stimulating production of white blood cells. The activation of the yeast cells is described using various electromagnetic fields. Interestingly, the yeast may be orally administered for augmentation of white blood cell number and activity. This is particularly useful for the treatment of immune suppressed patients...
Human foreskin fibroblasts for culturing ES cells
Patent Number: 7,267,981
Methods and compositions for modulating telomerase reverse transcriptase (TERT) expression
Patent Number: 7,279,328
Method of enhancing proliferation and/or hematopoietic differentiation of stem cells
Patent Number: 7,427,603
Growth of human Mesenchymal Stem Cells (hMSC) using umbilical cord blood serum and the method for the preparation thereof
Patent Number: 7060494
Methods of promoting osteogenesis
Patent Number: 7,268,139
Methods for the culture of human embryonic stem cells on human feeder cells
Patent Number: 7,432,104
Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (PACAP)
Patent Number: 7,368,115
Oral compositions for white blood cell activation and proliferation
Patent Number: 7,256,026