Class: Expansion (424)
Recombinant human albumin fusion proteins with long-lasting biological effects
Patent Number: 7,244,833This patent covers novel vectors for generating fusion proteins comprising one or more regions of the human albumin protein. The patent covers specific nucleotide sequences and most notable albumin-G-CSF fusions that have 5 times longer self life as compared to unmodified G-CSF and at least 3 fold longer half life in plasma. This patent is useful for entities seeking the generate...
Poly-Glu,Tyr for neuroprotective therapy
Patent Number: 7,399,740T regulatory cells are generally seen as antiinflammatory cells that are capable of suppressing pathological immune responses. These cells have been demonstrated to inhibit inflammatory pathologies such as bone resorption and transplant rejection.
The current patent takes an...
Method and composition for repairing and promoting regeneration of mucosal tissue in the gastrointestinal tract
Patent Number: 6685971This patent teaches methods of increasing activity of stem cells in the gastrointestinal tract through administration of a beeswax based composition. This patent is useful for treatment of various gastrointestinal disorders.
HoxD3 and HoxA3 compositions and methods for improved wound healing
Patent Number: 7,115,582This patent covers the use of HoxA3, and peptides, and nucleic acids derived from it for tissue regeneration. One particular use is the acceleration of wound healing, particularly for diabetes.
Device and a process for expansion of haemopoeitic stem cells for therapeutic use
Patent Number: 7,179,643The problem with cord blood as a source of stem cells is that not many cells can be harvested. Although enough cells are usually present to treat a pediatric patient, in cases of adults, expansion of stem cells from the cord blood is desirable. The current patent provides a portable bioreactor for expansion of cord blod stem cells. Essentially, the invention is designed so as to be able to...
Propagation and/or derivation of embryonic stem cells
Patent Number: 7,371,573This patent covers methods of growing embryonic stem cells outside of the body using novel tissue culture media and media additives.
Specifically, it covers the use of compounds that inhibit MEK-1 and/or MEK-2, as well as compounds that activate gp130 for use in stem cell propagation. This claim conceptually blocks anyone from using compounds known and unknown that modulate...
Method and device stimulating the activity of hair follicles
Patent Number: 6666878This patent provides various frequencies of light, and ways of administering light so as to stimulate proliferation and differentiation of the stem cell that is responsible for hair growth. It will be interesting to see if these methods and devices provided can also stimulate other types of stem cells. The use of light may also be beneficial for stimulating proliferation of cancer stem...
Numb protein expression inhibitors by Musashi
Patent Number: 7,264,793Musashi is a protein found on stem cells of the neural lineage. This patent covers the administration of Musashi to increase proliferation of neural stem cells. The patent also covers the use of Musashi to inhibit the repressor of Notch signalling Numb and thereby sensitize neural stem cells to proliferative/expansionive signals.
Method for stimulating hair follicle cell proliferation
Patent Number: 7,335,641The current patent covers ways of induce proliferation of hair follicle cells through administration of a specific protein or variants of it. The protein is called "hair follicle growth factor" or "HFGF". HFGF is considered to be an allelic form of keratinocyte growth factor-2 (KGF-2) wherein HFGF has a glutamic acid residue (Glu) at...
Hair follicle growth factor proteins
Patent Number: 7094569This patent is useful for induction of hair growth through use of hair follicle growth factor (HFGF) proteins. Essentially, the HFGF proteins described in the application appear to be allelic variants of keratinocyte growth factor-2 (also known as FGF-10). There are both composition of matter, use, and delivery claims issued. One of the...