Class: Expansion (424)
Methods and compositions for identifying morphogen analogs
Patent Number: 7,306,903One of the interesting methods of building up a patent portfolio is to cover not only therapeutic candidates, but also methods of identifying therapeutic candidates. In the current patent, the company Curis covers ways of identifying compounds that have morphogen activity. Specifically the patent covers methods of identifying compounds with similar biological effects as the morphogens OP-1...
Method of decreasing radiation of radio-mimetic chemotherapy for hematopoietic pluripotent cell engraftment
Patent Number: 6103694This patent teaches how to perform hematopoietic stem cell transplants without myeloablating the recipient. This patent provides specific doses of radiation that can mimic the effects of chemotherapy. This patent may be useful for other types of stem cell therapy in order to temporarily suppress the recipient immune system so as to allow the transplanted cells to engraft, establish...
Methods and compositions for modulation and inhibition of telomerase in vitro
Patent Number: 6054442This patent discloses small molecules that modulate activity of telomerase. On the one hand telomerase inhibition is useful for cancer therapy, on the other activation of telomerase is useful for longevity purposes.
Culture media for neurons, methods for preparing the culture media, and methods for culturing neurons
Patent Number: 6376238This patent provides a culture media for the growth of neuronal stem cells, and neurons themselves. The media is made using standard tissue culture components, with the exception that astroglial cells are used to condition it. The fact that astroglial cells normally produce various compounds that support the nervous system cells is what maybe triggered the inventor to think to condition...
Bioreactor for mammalian cell growth and maintenance
Patent Number: 6048721This patent provides new devices and culture conditions for expanding stem cells of the hematopoietic lineage ex vivo. This patent has actually been used for development of technologies that were used in clinical trials.
Methods for increasing hematopoietic cells
Patent Number: 6013067This patent teaches to treat a hematopoietic stem cell donor with thrombopoietic, collect the "activated" stem cells, and infuse them into a recipient. In some situations the recipient may also be given thrombopoietin.
Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
Patent Number: 6054441This patent covers small molecule stimulators of hematopoietic stem cell activity. These molecules appear to have a reasonable safety profile and are interesting for clinical development. One area of development may be their use in combination with cord blood transplants in adults...since cord blood transplants usually take a longer time to reconstitute.
Chemically defined medium for human mesenchymal stem cells
Patent Number: 5908782This patent provides serum free media for the growth, expansion, and differentiation of mesenchymal stem cells. Having media that can be used for expanding mesenchymal stem cells was a critical part of Osiris developing its advanced clinical program.
Selective expansion of target cell populations
Patent Number: 6338942This patent seems very interesting. It covers ways of selectively inducing proliferation of certain cell populations while "weeding out" cells that are not desirable. This patent is very useful in selection of stem cells and their progeny.
Methods of using aminothiols to promote hematopoietic progenitor cell growth
Patent Number: 5846958This patent covers a small molecule that is useful for expansion of hematopoietic stem cells in vivo. This small molecule would be interesting to use in a depot formulation and administered together with local cell therapy for the stimulation of angiogenesis.