Class: Expansion (424)
Low molecular weight cell, bone marrow and immune stimulants
Patent Number: 6498150This patent covers the composition of matter for several aminocarboxylic acid amide derivatives that are both immunostimulatory, as well as augment hematopoietic activity of stem cells. This seems very interesting a combination since many cytokines that stimulate the immune system, at least the Th1 arm of the immune system, are also suppressive to the hematopoietic compartment. For...
Methods of inducing immunity using low molecular weight immune stimulants
Patent Number: 6007819This patent covers a small molecular weight family of compounds that directly stimulate hematopoietic stem cell proliferation but at the same time have immune augmentative effects. Such compounds are especially useful after bone marrow transplantation for leukemias or cancers since post transplantation it is not only enough to have restored hematopoiesis, but augmentation of the immune...
G-CSF receptor agonists
Patent Number: 6100070This patent covers the composition of matter of several polypeptides and compounds that can activate the granulocyte colony stimulating factor receptor. These compounds can be developed into therapeutic agents for similar indications such those treated by Amgen's Neupogen.
Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
Patent Number: 6066318This patent covers variants of thrombopoietin and the use of these variants in combination with other hematopoietic cytokines for the stimulation of hematopoietic stem cells.
G-CSF receptor agonists
Patent Number: 6358505This patent provides various compositions of matters in the form of proteins that are useful for stimulating in an agonistic manner the receptor for granulocyte colony stimulating factor. This patent may be used for treatment of neutropenia as a way of getting around Amgen's G-CSF.
Manipulation of non-terminally differentiated cells using the notch pathway
Patent Number: 6149902This patent teaches how to expand stem cells of ectodermal, endodermal and mesodermal origin without inducing differentiation, by the activation of the notch pathway. This patent could be a very strong base for development of regenerative cell populations either allogeneic or autologous.
Compositions of mononuclear phagocytes useful for promoting axonal regeneration
Patent Number: 6117424This patent covers induction of neural regeneration through administration of monocytes and other immune cells. The immune cells may be administered for the treatment of spinal cord injury. This is actually in clinical trials right now.
Cerebellum-derived growth factors
Patent Number: 5912326This patent discloses a polypeptide that is involved in the formation of various brain structures. This polypeptide is useful for stem cell differentiation and expansion.
Method of cell culture using neurturin
Patent Number: 6743628This patent teaches how to expand neuronal stem cells through administration of the protein neurturin. The patent seems to be restricted to in vitro use.
Method for providing trophic support for neurons comprising administering neurturin
Patent Number: 5817622This patent teaches that administration of neurturin can increase survival and induce expansion of neural stem cells. It would be interesting to see if neurturin can also effect hematopoiesis, given the similarity between stem cells of the hematopoietic and neural lineages.