Class: Differentiation (190)
Human and mammalian stem cell-derived neuron survival factors
Patent Number: 7,273,725This is a composition of matter patent covering polypeptide sequences for "Stem cell-Derived Neuron Survival Factors" (SDNSF). The polypeptides appear to be secretory and to represent natural factors that induce neural stem cell self-renewal and differentiation. In the examples section the inventors treated neurospheres with SDNSF and demonstrated increased...
Method of in vitro differentiation of transplantable neural precursor cells from primate embryonic stem cells
Patent Number: 6887706This patent is from the same group that originally patented embryonic stem cells of human. In the current patent there is one independent claim that covers the differentiation of human embryonic stem cells into neural progenitor cells. The method claims involves culturing so that embryoid bodies are formed from the embryonic stem cells through incubation with
Pine cone extracts and uses thereof
Patent Number: 7,338,676Dendritic cells are the most potent stimulators of the immune system, having the unique ability to activate naive T cells. Thus dendritic cells are of great interest in terms of immune stimulatory approaches for treatment of cancer and viral diseases. On the flip side of the coin, dendritic cells are known to have the ability of...
Reconstructed laminae of human epithelium corneae and method of producing the same
Patent Number: 6610538This patent teaches how to generate corneal epithelium in vitro from stem cell sources.
N-phenyl-3-pyrimidine-amine derivatives
Patent Number: 7,329,661This patent covers the treatment of a "proliferative disorder" using a family of compounds which include N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-piperazin-1-- ylmethyl-benzamide methanesulfonate. These agents inhibit stem cell factor signalling, as well as signalling of PDGF.
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Multi-lineage directed induction of bone marrow stromal cell differentiation
Patent Number: 7,364,900This patent covers a 2 step method of generating insulin producing cells.
According to the first issued claim, the initial step involves obtaining what essentially appears to be a mesenchymal stem cell (adherent cell positive for CD44, CD90 and CD71, negative for monocyte and hematopoietic markers, CD11b and CD45, respectively) and culturing them with an antioxidant in order to generate...
Method for rapid generation of mature dendritic cells
Patent Number: 7,354,909Dendritic cells are the most potent stimulators of the immune system. Generally it is the dendritic cell that picks up antigens and makes the decision whether the immune system should "get mad" and go after the antigen, or whether the antigen represents no substantial danger and therefore should be ignored. In some cases the dendritic...
Platelet-derived growth factor protection of cardiac myocardium
Patent Number: 7,514,261Bone marrow has been conventionally used as a source of hematopoietic stem cells for bone marrow transplant. More recently it has been shown that bone marrow can differentiate (either its hematopoietic or mesenchymal components) into various tissues including neural, hepatic and
Cardiomyocyte precursors from human embryonic stem cells
Patent Number: 7,425,448Geron has taken a very strategic approach to embryonic stem cells. They inlicensed composition of matter patents on embryonic stem cells, such as #5,843,780 from the Wisconsin Alumni Research Foundation (WARF), they patented methods of culturing embryonic stem cells in serum free conditions so to allow for clinical use (#
Islet cells from human embryonic stem cells
Patent Number: 7033831This patent covers a method of generating insulin producing cells from human embryonic stem cells through the process of first incubating the human embryonic stem cells with Activin A, and then subsequently incubating the cells with nicotinamide. Activin is a peptide involved in wound healing and morphogenesis, wherease nicotinamide is a type of vitamine B3 and improves beta cell functions...