Class: Differentiation (190)
Schwann cells originating in myeloid interstitial cells
Patent Number: 6989271Schwann cells generate myelin (insulates neuronal electrical signals [amognst other things]) and are essential for the proper function of neuronal tissue. Various neurological diseases would benefit from the ability to introduce Schwann Cells that are properly functioning. The current patent teaches ways of using bone marrow stromal cells as a source of Schwann Cells. Specifically the patent...
Method for neural stem cell differentiation using valproate
Patent Number: 7,132,286This patent covers the use of valproic acid for inducing differentiation of neurons from neural stem cells. This patent seems to be restricted in the claims to the in vitro differentiation of neurons. What is interesting is whether the concentrations claimed in the patent are actually achievable in vivo. Since valproic acid is clinically used as an anticonvulsant, it is interesting to...
Method for neural stem cell differentiation using 5HT-1A agonists
Patent Number: 7,132,287This patent teaches that culture of neuronal stem cells in the presence of an 5HT1A agonist (for example serotonin) will induce differentation into neurons.
Keratinocytes obtained from embryonic stem cells of mammals
Patent Number: 7,186,558The current patent is useful for parties interested in generation of keratinocytes from embryonic stem cells. The patent covers the induction of differentiation of embryonic stem cells into keratinocytes through exposure of embryonic stem cells to various extracellular matrices obtained from a mammal. Specific ECM proteins include laminin-5, type IV collage, type I...
Directed in vitro differentiation of marrow stromal cells into neural cell progenitors
Patent Number: 7,547,545This patent covers the generation of neurons from mesenchymal stem cells, or like the inventor calls them "mesenchymal stromal cells", which is the more politically correct way of naming them.
Very broad claims are issued, the first one being: "A method of producing a neural progenitor cell, said method comprising contacting an... This patent covers the induction of dedifferentiation, followed by transdifferentiation for regenerating mammalian lens. The patent covers the steps of inducing dedifferentiation in an eye lens using a surgical procedure, followed by inducing the transdifferentation through administration of guanosine, and then “fixing” the transdifferentiated effect through abministration of... Mesenchymal stem cells are currently in Phase III of clinical trials by companies such as Osiris. Additionally, numerous academic institutions are conducting clinical trials for mesenchymal stem cells.
The current patent covers the differentiation of mesenchymal stem cells into neurons by culture with... This patent covers ways of manufacturing cells that express dopaminergic neurons for implantation. Obviously one of the uses for these cells is treatment of Parkinson's. While others have generated dopaminergic neurons from sources such as subventricular zone precursors, olfactory epithelium, and
Methods for regeneration of a mammalian lens
Patent Number: 7,176,189
Method for differentiating mesenchymal stem cells into neural cells
Patent Number: 7,229,827
Differentiation of specialized dermal and epidermal cells into neuronal cells
Patent Number: 7,361,506
Production of tyrosine hydroxylase positive neurons
Patent Number: 6844312Neurons that express tyrosine hydroxylase (TH) are subfunctional in diseases such as Alzheimer's and Parkinson's. This patent teachs how to generate TH expressing neurons through contacting stem cells with FGF-1, an agent that activates protein kinase A, as well as a phorbol ester and dopamine. The ability to generate TH neurons in this manner may lead not only...
Modulation of primary stem cell differentiation using an insulin-like growth factor binding protein
Patent Number: 6841386Insulin like growth factor (IGF) is involved in numerous biological activities. The basis of this patent is that IGF possesses some differentiation inducing activity for CD34+ CD38- hematopoietic stem cells. The ability of stem cells to be expanded ex vivo depends on not allowing said cells to differentiate...