Class: Differentiation (190)
Process for producing nerve stem cells, motor neurons, and GABAergic neurons from embryonic stem cells
Patent Number: 7,294,510This patent covers the generation of neurons through inducing embryonic stem cells to differentiate using the noggin protein and combinations of noggin with other factors. Noggin is an antagonist of bone morphogenic proteins and has been demonstrated to regulate numerous stem cell activities in vivo. The patent essentially teaches the use of noggin and ES cells for: - forming embryoid...
CD8.alpha..sup.+lymphoid dendritic cell differentiated from human hematopoietic stem cell and a method for differentiation
Patent Number: 7,390,658Dendritic cells are the most potent antigen presenting cell, capable of activating naive T cells, as well as inducing generation of suppressor T cells. Given the potent ability of dendritic cells to stimulate the immune system, they have been used as "natural adjuvants" in cancer therapy. A discussion of the tolerogenic and tolerance...
Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway
Patent Number: 7,202,080This patent teaches methods of generating pancreatic-like cells for either hematopoietic stem cells or mesenchymal stem cells. The patent covers the use of specific tissue culture cocktail which contains various growth factors, for inducing expression of pancreatic genes in cells of CD34 or mesenchymal lineage. The patent does not document in vivo activity of the...
Protein-induced tissue morphogenesis
Patent Number: 6565843This patent teaches the use of the protein osteogenic protien-1 (OP-1) for the induction of tissue differentiation from stem cells. The invention is aimed primarily at induction of bone formation from osteogenic precursor cells.
Thrombopoietin mimetics
Patent Number: 7,241,783Thrombopenia, induced by chemotherapy, malignancy or radiotherapy is a substantial clinical problem. Protein therapeutics such as G-CSF have been developed and clinically implimented to deal with leukopenia. Similarly, thrombopoietin is under development as a treatment for thrombopenia. Unfortunately, various characteristics of the whole protein make it not an optimal treatment. The current...
Generation and use of dendritic cells
Patent Number: 7,405,076Plasticity of stem cells to differentiate into various tissues is often a subject of much debate, especially in terms of bone marrow hematopoietic stem cells becoming hepatocytes or cardiac cells. While some scientists state that a hematopoietic stem cell will only differentiate into blood cells, others point to the clinical evidence that administration of, for example bone marrow...
Compounds and methods for regulating cell differentiation
Patent Number: 6908732The use of various bile extracts for treatment of cancer is known in the art. The Canadian company Lorus Therapeutics developed a drug called Virulizing from cow bile extracts. This patent teaches the use of bilins for treatment of cancer through induction of cellular differentiation. The advantage of inducing cancer cell differentiation is the possibility of a less toxic approach in...
Compounds and methods for regulating cell differentiation
Patent Number: 6902881This patent teaches the use of a bilin for treating cancer through induction of differentiation. It is a very promising idea since differentiation therapy is relatively non-toxic. The question is what concentrations of these bilins are needed to actually see an in vivo effect. The 2 independent claims of the patent are: A method for promoting cell differentiation, comprising treating...
Primitive neural stem cells and method for differentiation of stem cells to neural cells
Patent Number: 7,211,434Generation of neurons and neuronal committed cells from embryonic stem cells has been extensively documented by separation of cells from embryoid bodies. However the generation of embryoid bodies from embryonic stem cells is subject to US patent #"6602711":https://www.stemcellpatents.com/patents-show-373 which is owned by WARF and licensed to Geron. So while the...
Substituted 5-alkynyl pyrimidines having neurotrophic activity
Patent Number: 7,205,297This patent discloses a series of companies that are substituted 5-alkynyl pyrimidines with nerve growth factor-like (NGF) activity for treatment of neurological disorders.
Essentially, the data the inventors disclosed in the patent is that these compounds they generated can induce promotion of neurite outgrowth and elevation of choline acetyltransferase in the PC12...