Class: Differentiation (190)
Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
Patent Number: 7,285,415The central nervous system is comprised of neurons and glia, with approximately ten times more glial cells than neurons. The function of glial cells is primarly to provide insulation(ie generation of myelin by oligodendrocytes), destroy pathogens/clear debris (microglia), provide structural support to neurons, as well as providing nutrients and growth factors. Astrocytes are the most...
Modulation of stem and progenitor cell differentiation, assays, and uses thereof
Patent Number: 7,498,171One of the areas in which regenerative medicine is heading is the use of "drugs" to modulate the stem cell compartment. For example, we have previously seen companies like Stem Cell Therapeutics performing clinical trials with EPO and hCG for stroke. Drugs already in the clinic such as Velcade, have also been... This patent covers the generation of vascular smooth muscle cells from embryonic stem cells through specific culture conditions. In one embodiment the differentiation is induced through exposure to the cytokines TGF, angiopoietin, and platelet derived growth factor BB. In the examples section the generation of SMA positive cells from embryonic stem cells is demonstrated, as... It is known that embryonic stem cells can be differentiated into a wide variety of tissues in vitro. In this patent, methods are disclosed for generating trophoblasts from ES cells through culture in BMP2, BMP4, BMP7, and GDF5.
Although the patent teaches uses of the trophoblasts generated for research purposes, a very interesting... The invention teaches how to make liver stem cells into cells that resemble pancreatic endocrine cells (ie islets). The patent has 1 independent claim, basically covering a method of endowing hepatic stem cells with an endocrine pancreatic characteristic by first isolating hepatic stem cells from 2-acetylamino-fluorene-treated adult rats and then growing the cells in a medium made of >5.5... This patent covers the monitoring of numerous genes as a marker of hematopoietic stem cells proliferation, differentiation, and/or induction into apoptosis. This patent is useful for screening of compounds for potential hematopoietic modulatory activity, as well as in vivo assessment of drugs. Particularly, in clinical trials it is better if some of these "biomarkers" can be prognostic of... This is one of Geron's numerous patents covering not only composition of matter for various stem cells (licensed from WARF) but also methods of actually differentiating the cells into different other cells that are useful either potentially for therapy or for research use.
The current patent covers generation of endoderm through culturing of ES cells with Activin... This invention is useful for treatment of diabetes using encapsulated cells. The invention consists of one independent claim that appears to cover a method for treating diabetes by administration of encapsulated cells that have a specific set of biological and physical properties. The cells appear to be a type of intermediatery cell, or a progenitor cell that is capable of expansion. It is known that endothelial cell dysfunction is one of the major causes of morbidity and mortality in the Western world. For example, if endothelium could properly respond to the hypoxic conditions associated with cardiac angina and form new blood vessels, then heart disease would take such a heavy toll on today’s society. This is just a limited example, atherosclerosis, various tissue... This patent teaches the generation of neurons from culturing of whole bone marrow in basic fibroblast growth factor and epidermal growth factor.
This patent may be useful as a simple and easy to generate source of cells for therapy of neurodegenerative diseases.
Generating vascular smooth muscle cells in vitro from ES cells
Patent Number: 7,354,763
Method for generating primate trophoblasts
Patent Number: 7,148,062
Method for differentiating rat hepatic stem cells to insulin-producing cells
Patent Number: 7029915
Methods for identifying compounds which modulate hematopoiesis
Patent Number: 7,250,262
Endoderm cells from human embryonic stem cells
Patent Number: 7,326,572
In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development
Patent Number: 7101546
Endothelial cells derived from primate embryonic stem cells
Patent Number: 7,176,023
Differentiation of whole bone marrow
Patent Number: 7,129,034