Class: Differentiation (190)
Hepatocyte lineage cells derived from pluripotent stem cells
Patent Number: 6506574This patent teaches how to generate hepatocytes by the differentiation of embryonic stem cells. Methods of using the newly generated hepatocytes for drug screening are also provided. The patent describes uses of histone decetylase inhibitors in the culture and differentiation process.
Hepatocyte lineage cells derived from pluripotent stem cells
Patent Number: 6458589This patent covers methods of generating and isolating hepatocytes from embryonic stem cells. The hepatocytes are designated by specific phenotypic and functional characteristics that are described in the patent. This invention could be useful for treatment of a wide variety of disorders ranging from hepatitis to cirrhosis.
Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
Patent Number: 6774120This patent teaches how to make liver cells behave like pancreatic cells and even offers the possibility of treating type 1 diabetes. Essentially the patent claims that by transfecting liver cells with the pancreatic stem cell transcription factor PDX-1, the liver cells will start producing insulin (besides other things).
Therapeutic uses for mesenchymal stromal cells
Patent Number: 6673606This patent teaches how to induce the differentiation of mesenchymal stem cells into oligodendrocyte cells. These oligodendrocytes may be used for treatment of various metabolic and nervous system disorders.
Embryonic stem cells and neural progenitor cells derived therefrom
Patent Number: 7,504,257This patent covers methods of generating neural progenitor cells from embryonic stem cells in vitro. In its one issued claim the inventors teach the administration of EGF and FGF-2 to serum-free media containing undifferentiated pluripotent human embryonic stem cells in order to give rise to tripotent neural progenitor cells. The neural progenitor cells are capable of...
Method of making embryoid bodies from primate embryonic stem cells
Patent Number: 6602711This is a patent for forming what is called "embryoid bodies" which are cellular aggregated generated from embryonic stem cells. Embryoid bodies can be subsequently dissociated in order to form various histological tissues useful for regenerative purposes.
Differentiation of bone marrow cells into neuronal cells and uses therefor
Patent Number: 7,279,331This patent covers the differentiation of bone marrow stromal stem cells into neurons through the addition of antioxidants. The patent is limited to in vitro differentiation. Specific antioxidants that the inventors cover for the in vitro generation of neurons include beta-mercaptoethanol, dimethylsulfoxide, butylated hydroxytoluene, butylated hydroxyanisole, ascorbic acid...
Erythrocytic cells and method for preserving cells
Patent Number: 6770478This patent covers methods of preserving red blood cells through cryopreservation. The method involves depletion of cholesterol and loading of the cells with an oligosaccharide. Cryopreservation according to this method may be performed in stem cell derived erythrocytes for use in emergency situations.
Progenitor cells and methods and uses related thereto
Patent Number: 6610535This patent teaches the generation of islet like cells from pancreatic stem cells. It is useful for the treatment of diabetes. One source of stem cells used in this patent is pancreatic duct stem cells.
Directed differentiation of human embryonic cells
Patent Number: 7045353This is basically the patent that covers how to generate neurons from embryonic stem cells. Of course the various composition of matter patents on embryonic stem cells (5,843,780, 6,200,806, 7,029,913) have to be in-licensed to use this invention. The invention has one broad independent claim which covers a method of differentiating human embryonic stem cells into neurons. The method...