Patents
Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction
Patent Number: 6248725This is an interesting patent that teaches the concurrent administration of the thyroid hormone T3, together with keratinocyte growth factor (KGF) can stimulate proliferation of endogenous hepatic stem cells.
Inventors: Alison, Malcom R. (London, GB); Coutelle, Charles (London, GB); Forbes, Stuart J. (Middlesex, GB); Hodgson, Humphrey J. F. (London, GB); Sarosi, Ildiko (Thousand Oaks, CA); Themis, Michael (Buckinghamshire, GB)
Assignee: Amgen, Inc. (Thousand Oaks, CA)
Date of First Priority Issue: Tuesday February 23rd, 1999
Medium for preserving biological materials
Patent Number: 6248588This patent teaches how to store various biological tissues and cells, including stem cells, through the injection of various cryopreservants into said tissues or cells.
Inventors: Crespo, Andre (Ormesson, FR); Soria, Henri Michel (Monts, FR)
Assignee: Aventis Pharms S.A. (Antony, FR)
Date of First Priority Issue: Tuesday March 12th, 1996
Method for promoting mesenchymal stem and lineage-specific cell proliferation
Patent Number: 6248587This patent provides the use of angiotensinogen I, II, and various analogues thereof in order to accelerate proliferation and differentiation of mesenchymal stem cells that are in contact with various types of other cells.
Inventors: Rodgers, Kathleen E. (Long Beach, CA); DiZerega, Gere (Pasadena, CA)
Assignee: University of Southern Cailfornia (Los Angeles, CA)
Date of First Priority Issue: Friday January 23rd, 1998
Human embryonic germ cell line and methods of use
Patent Number: 6245566This patent covers human primordial germ stem cells. These cells can be used for generating a variety of different stem cell lines, as well as for in vitro generation of various germ cells.
Inventors: Gearhart, John D. (Baltimore, MD); Shamblott, Michael Joseph (Baltimore, MD)
Assignee: The Johns Hopkins University School of Medicine (Baltimore, MD)
Date of First Priority Issue: Friday December 12th, 1997
Antigen found on a small subset of human hematopoietic cells which binds to monoclonal antibody MG1
Patent Number: 6242579This patent covers an antigen that is found on some types of hematopoietic stem cells. This antigen can be used for purification of hematopoietic stem cells by magnetic or flow cytometric means.
Inventors: Lawman, Michael J. P. (Key Largo, FL); Lawman, Patricia (Key Largo, FL)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Wednesday November 13th, 1996
Hepatic progenitors and method of isolating same
Patent Number: 6242252This patent covers a type of hepatic stem cell that expresses OX-43, OX-44, and/or OC3.
Inventors: Reid, Lola M. (Chapel Hill, NC); Sigal, Samuel H. (Riverdale, NY); Brill, Shlomo (Ramat-Gan, IL); Holst, Patricia A. (Ossining, NY)
Assignee: Albert Einstein College of Medicine of Yeshiva University (Bronx, NY)
Date of First Priority Issue: Wednesday August 7th, 1991
Human hematopoietic progenitor cell preparations and their expansion in a liquid medium
Patent Number: 6241984This patent covers autologous hematopoietic stem cell transplants with ex vivo expansion through an IL-3 + GM-CSF fusion protein, and/or with stem cell factor.
Inventors: Hoffman, Ronald (Palo Alto, CA); Brandt, John (Palo Alto, CA)
Assignee: The Indiana University Foundation (Bloomington, IN)
Date of First Priority Issue: Tuesday April 9th, 1991
Use of collagenase in the preparation of neural stem cell cultures
Patent Number: 6238922This patent teaches that tissue samples, or neurospheres, may be dissociated with collagenase instead of mechanical means, in order to maintain viability of the stem cell component.
Inventor: Uchida, Nobuko (Palo Alto, CA)
Assignee: StemCells, Inc. (Sunnyvale, CA)
Date of First Priority Issue: Friday February 26th, 1999
CICM cells and non-human mammalian embryos prepared by nuclear transfer of a proliferating differentiated cell or its nucleus
Patent Number: 6235970This patent teaches ways of generating stem cells, and inner cell mass cells through nuclear transfer. This patent is important for generation of embryonic stem cells, and offers the possibility of generation of autologous embryonic stem cells by nuclear transfer techniques.
Inventors: Stice, Steven L. (Belchertown, MA); Cibelli, Jose (Amherst, MA); Robl, James (Belchertown, MA); Golueke, Paul (Belchertown, MA); Ponce de Leon, F. Abel (Amherst, MA); Jerry, D. Joseph (Shutesbury, MA)
Assignee: University of Massachusetts, Amherst Campus (Amherst, MA)
Date of First Priority Issue: Friday January 10th, 1997
Programmable antigen presenting cell of CD34 lineage
Patent Number: 6228640Disclosed in this patent are methods of generating antigen-loaded dendritic cells useful for cancer immunotherapy, through the differentiation of hematopoietic stem cells.
Inventors: Cezayirli, Cem (Birmingham, AL); Silvers, Mel (North Miami Beach, FL)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday February 7th, 1997