Patents
Method for homing hematopoietic stem cells to bone marrow stromal cells
Patent Number: 6258354This patent covers the use of gene transfected stromal cells in order to increase engraftment of a hematopoietic stem cell transplant.
Inventor: Greenberger, Joel S. (Lincoln, MA
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday September 29th, 1989
Porcine neural cells and their use in treatment of neurological deficits due to neurodegenerative diseases
Patent Number: 6258353This patent covers the use of a specialized cell population obtained from xenogeneic sources for the stimulation of recovery of various neurological disorders. Specifically, the patent covers pig lateral ganglionic eminence cells that are treated so as to not elicit immune rejection.
Inventors: Isacson, Ole (Cambridge, MA); Dinsmore, Jonathan (Brookline, MA)
Assignee: Diacrin, Inc. (Charlestown, MA)
Date of First Priority Issue: Tuesday November 8th, 1994
Method of treating huntington's disease using HNT neurons
Patent Number: 6254865This patent covers the use of neural terminally differentiated teratocarcinoma cells (hNT) for the treatment of Huntington's disease. This technology has actually been used in clinical trials.
Inventors: Freed, Curt R. (Denver, CO); Kaddis, Farida G. (Lakewood, CO)
Assignee: University Technology Corporation (Boulder, CO)
Date of First Priority Issue: Tuesday June 17th, 1997
Regulation of hematopoietic stem cell differentiation by the use of human mesenchymal stem cells
Patent Number: 6255112This patent covers the use of mesenchymal stem cells to stimulate hematopoietic stem cells. Mesenchymal stem cells are actually in Phase III trials for prevention of graft versus host after hematopoietic stem cell transplants. This patent ensures that if the mesenchymal stem cells also stimulate hematopoiesis, then Osiris is covered from an IP perspective.
Inventors: Thiede, Mark A. (Forest Hill, MD); Mbalaviele, Gabriel (Columbia, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Monday June 8th, 1998
Unactivated oocytes as cytoplast recipients of quiescent and non-quiescent cell nuclei, while maintaining correct ploidy
Patent Number: 6252133This patent covers a method of increasing efficacy of the cloning process. Cloning may be used as a source for the generation of stem cells of the embryonic type.
Inventors: Campbell, Keith Henry Stockman (Midlothian, GB); Wilmut, Ian (Midlothian, GB)
Assignee: Roslin Institute (Edinburgh) (Midlothian, GB); The Minister of Agriculture, Fisheries & Food (London, GB); Biotechnology & Biological Sciences Research Council (Swindon, GB)
Date of First Priority Issue: Thursday August 31st, 1995
Compositions and methods of making embryonic stem cells
Patent Number: 6251671This patent covers methods of generating spermatogonial stem cells. These stem cells may be used for a wide variety of regenerative purposes, as well, they appear similar in some ways to the cells generated by the company Primegen.
Inventors: Hogan, Brigid L. M. (Brentwood, TN); Zhao, Guang-Quan (Nashville, TN)
Assignee: Vanderbilt University (Nashville, TN)
Date of First Priority Issue: Wednesday February 28th, 1996
Neuronal progenitor cells and uses thereof
Patent Number: 6251669This patent covers a type of neural stem cell. In one embodiment the stem cells can be differentiated into gamma aminobutyric acid (GABA) expressing neurons.
Inventor: Luskin, Marla B. (Decatur, GA)
Assignee: Emory University (Atlanta, GA)
Date of First Priority Issue: Thursday July 6th, 1995
Directed maturation of stem cells and production of programmable antigen presenting dentritic cells therefrom
Patent Number: 6251665This patent covers the use of hematopoietic stem cells to generate dendritic cells. The dendritic cells disclosed are able to elicit an antitumor immune response.
Inventors: Cezayirli, Cem (Birmingham, AL); Silvers, Mel (N. Miami Beach, FL)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday February 7th, 1997
Method for ex-vivo expansion of hematopoietic cells
Patent Number: 6251383This patent covers the use of an extract of the plant called Tinospora cordifolia for stimulation of hematopoietic stem cells.
Inventors: Upadhyay, Shakti N. (New Delhi, IN); Madan, Vikas (New Delhi, IN)
Assignee: National Institute of Immunology (New Delhi, IN)
Date of First Priority Issue: Tuesday April 20th, 1999
Stimulating the differentiation of preadipocytic cells and therapies based thereon
Patent Number: 6248791This patent covers ways of inducing the differentiation of cells into adipocytes that are responsive to insulin. This is for the treatment of type II diabetes.
Inventors: Ailhaud, Gerard (Nice, FR); Grimaldi, Paul (Nice, FR); Safonova, Irina (Nice, FR); Shroot, Braham (Antibes, FR); Reichert, Uwe (Pont du Loup, FR)
Assignee: Centre International de Recherches Dermatologiques Galderma (Valbonne, FR)
Date of First Priority Issue: Saturday April 2nd, 1994