Patents
Production of megakaryocytes by the use of human mesenchymal stem cells
Patent Number: 6225119This patent teaches that mesenchymal stem cells can be used to support the production of platelets from hematopoietic stem cells. Additionally, the patent covers genetically transformed hematopoietic stem cells in contact with mesenchymal stem cells for the generation of genetically transformed platelets.
Inventors: Qasba, Pankaj (Columbia, MD); Thiede, Mark A. (Forest Hill, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Friday May 22nd, 1998
Method for repopulating human bone marrow comprising culturing CD34+ cells in a serum free medium
Patent Number: 6224860This patent provides a culture media that can be used for the expansion of hematopoietic stem cells in vivo for use in transplantation.
Inventor: Brown, Ronald L. (Derwood, MD)
Assignee: Quality Biological, Inc. (Gaitersburg, MD)
Date of First Priority Issue: Friday October 18th, 1996
Hemopoietic stem cell multiplier
Patent Number: 6221359This patent covers the use of hepatocyte growth factor (and various combinations) for the stimulation of hematopoietic stem cells.
Inventors: Komiyama, Atsushi (Matsumoto, JP); Nakahata, Tatsutoshi (Matsumoto, JP); Kubo, Tetsuo (Matsumoto, JP); Tanaka, Ryuhei (Tsu, JP); Kawano, Genji (Kamakura, JP); Sudo, Tetsuo (Kamakura, JP); Sano, Emiko (Yokohama, JP); Kojima, Katsuaki (Yokohama, JP)
Assignee: Toray Industries, Inc. (Tokyo, JP)
Date of First Priority Issue: Friday July 26th, 1991
Repopulation of testicular seminiferous tubules with foreign cells, corresponding resultant germ cells, and corresponding resultant animals and progeny
Patent Number: 6215039This patent teaches ways of repopulating the testicles with stem cells and/or other cells so that the resulting animal may have offspring that are genetically different.
Inventor: Brinster, Ralph L. (Gladwyne, PA)
Assignee: The Trustees of the University of Pennsylvania (Philadelphia, PA)
Date of First Priority Issue: Friday December 6th, 1991
Mesenchymal stem cells for cartilage repair
Patent Number: 6214369This patent covers the use of mesenchymal stem cells for generation of bone and cartilage. It is interesting that Osiris has patents in this area as well.
Inventors: Grande, Daniel A. (Sea Cliff, NY); Lucas, Paul A. (Macon, GA)
Assignee: MorphoGen Pharmaceuticals, Inc. (Downey, CA)
Date of First Priority Issue: Tuesday March 14th, 1995
Compositions and methods for producing and using homogenous neuronal cell transplants to treat neurodegenerative disorders and brain and spinal cord injuries
Patent Number: 6214334This patent covers a neuronal stem cell line that is useful for treatment of central and peripheral nervous system disorders.
Inventors: Lee, Virginia M. -Y. (Philadelphia, PA); Trojanowski, John Q. (Philadelphia, PA)
Assignee: Trustees of the University of Pennsylvania (Philadelphia, PA)
Date of First Priority Issue: Monday October 21st, 1991
Methods for treating cancer using allogeneic lymphocytes without graft vs host disease activity
Patent Number: 6213127This patent teaches ways of administering allogeneic lymphocytes that have been treated chemically or with radiation so as to elicit an antitumor effect while at the same time not causing graft versus host.
Inventor: Waller, Edmund K. (Atlanta, GA)
Assignee: Emory University (Atlanta, GA)
Date of First Priority Issue: Tuesday September 1st, 1998
Stem cell factor and compositions
Patent Number: 6207802This is one of the composition of matter patents on the stem cell stimulatory cytokine called "stem cell factor". Since the receptor for this cytokine, c-kit, is present on numerous other types of stem cells (ie cardiac, muscle, kidney stem cells), it is of interest whether this cytokine can also be of use in expanding non-hematopoietic stem cells.
Inventors: Zsebo, Krisztina M. (Thousand Oaks, CA); Bosselman, Robert A. (Thousand Oaks, CA); Suggs, Sidney V. (Newbury Park, CA); Martin, Francis H. (Thousand Oaks, CA)
Assignee: Amgen Inc. (Thousand Oaks, CA)
Date of First Priority Issue: Monday October 16th, 1989
Preservation of tissue during removal storage and implantation
Patent Number: 6207658Disclosed are various formulations and chemicals in which cells and tissue can be stored for prolonged time periods.
Inventors: Simpkins, James W. (Gainesville, FL); Green, Pattie S. (Gainesville, FL); Gridley, Kelly E. (Gainesville, FL)
Assignee: University of Florida Research Foundation, Inc. (Gainesville, FL)
Date of First Priority Issue: Thursday January 11th, 1996
Implantable system with drug-eluting cells for on-demand local drug delivery
Patent Number: 6206914This patent covers the use of cells, including stem cells and derivatives, for producing certain drugs or proteins specifically upon stimulation. Stimulation may be electrical, mechanical, or chemical.
Inventors: Soykan, Orhan (New Brighton, MN); Donovan, Maura G. (St. Paul, MN) )
Assignee: Medtronic, Inc. (Minneapolis, MN
Date of First Priority Issue: Thursday April 30th, 1998