Patents
Methods for use of Mpl ligands with primitive human stem cells
Patent Number: 6326205Thrombopoietin (TPO) is a stimulatory molecule for early hematopoietic stem cells. In this patent the use of TPO and other ligands of its receptor, called mpl, are disclosed for purposes of expansion, and/or megakaryocytic differentiation of hematopoietic stem cells. It would be interesting to see if other types of stem cells also respond to mpl ligands in the manner that hematopoietic stem...
Inventors: Murray, Lesley J. (San Jose, CA); Young, Judy C. (San Carlos, CA)
Assignee: Systemix, Inc. (Palo Alto, CA)
Date of First Priority Issue: Monday October 30th, 1995
Methods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
Patent Number: 6326198This patent provides systems for expanding hematopoietic stem cells, but culturing of these cells on stromal cells which secrete IL-6, and/or GM-CSF. It is important for the stromal cells to be secreting these compounds since stromal cells possess a wide variety of hematopoietic stimulatory signals, some known and others unknown. The synergy of the stromal signals with IL-6 and/or GM-CSF is used...
Inventors: Emerson, Stephen G. (Ann Arbor, MI); Clarke, Michael F. (Ann Arbor, MI); Palsson, Bernhard O. (Ann Arbor, MI)
Assignee: Regents of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Thursday June 15th, 1989
Implantable biocompatible immunoisolatory vehicle for the delivery of selected therapeutic products
Patent Number: 6322804This patent provides methods of encapsulating cells so that they will not be rejected by the recipient immune system. Encapsulation devices such as this should be considered not only for the protection of the cells that are administered, but also for protection of the host from the cells. For example, lets say that embryonic stem cells are administered into a degenerating organ for the...
Inventors: Dionne, Keith E. (Rehoboth, MA); Emerich, Dwaine F. (Providence, RI); Hoffman, Diane (Cambridge, MA); Sanberg, Paul R. (Spring Hill, FL); Christenson, Lisa (New Haven, CT); Hegre, Orion D. (Green Valley, AZ); Scharp, David W. (St. Louis, MO); Lacy, Paul E
Assignee: Neurotech S.A. (Evry, FR)
Date of First Priority Issue: Thursday April 25th, 1991
Adipogenic differentiation of human mesenchymal stem cells
Patent Number: 6322784Mesenchymal stem cells can differentiate into a variety of cellular lineages. In this patent the ability of mesenchymal stem cells to be induced into the adipocyte lineage is covered.
Inventors: Pittenger, Mark F. (Severna Park, MD); Beck, Stephen C. (Reistertown, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD
Date of First Priority Issue: Tuesday July 30th, 1996
Methods for stimulating erythropoiesis using hematopoietic proteins
Patent Number: 6316254This patent covers the use of TPO (thrombopoietin) for the stimulation of hematopoietic stem cells to differentiate into red blood cells. Classically, as the name implies, TPO is considered a growth factor that induces differentiation of hematopoietic stem cells into the megakaryocytic lineage (ie to make platelets).
Inventor: Kaushansky, Kenneth (Woodinville, WA)
Assignee: University of Washington (Seattle, WA
Date of First Priority Issue: Monday February 14th, 1994
Methuselah gene, compositions and methods of use
Patent Number: 6303768Methuselah is a gene, which certain variants of it are associated with life extension. The mechanisms of action are not completely known, however it appears that it acts along the pathway of reducing cellular metabolic stress.
Inventors: Lin, Yi-Jyun (Arcadia, CA); Benzer, Seymour (San Marino, CA)
Assignee: California Institute of Technology (Pasadena, CA)
Date of First Priority Issue: Monday September 7th, 1998
Genetic modification of primate hemopoietic repopulating stem cells
Patent Number: 6312957Hematopoietic stem cells are an ideal vector for gene therapy since they repopulate the whole body, and in some cases can differentiate into various tissues in the body. This patent teaches the use of adeno-associated virus vectors to transfect hematopoietic stem cells so that the hematopoietic stem cells can repopulate the host and deliver the protein product of the gene to where it is...
Inventors: Einerhand, Markus Peter Wilhelmus (Amsterdam, NL); Valerio, Domenico (Leiden, NL)
Assignee: Introgene B.V. (NL)
Date of First Priority Issue: Thursday December 5th, 1996
Methods for preparing enriched human hematopoietic cell preparations
Patent Number: 6306575This patent provides kits for negatively depleting a population of cells so that what remains is hematopoietic stem cells. Different variants of this kit are sold by the Canadian company StemCell Technologies.
Inventors: Thomas, Terry (Vancouver, CA); Lansdorp, Peter (Vancouver, CA)
Assignee: StemCell Technologies, Inc. (Vancouver, CA)
Date of First Priority Issue: Friday June 16th, 1995
Foam composite for the repair or regeneration of tissue
Patent Number: 6306424This patent provides various compositions of matter for making foam implants that can be used to deliver cells into a host.
Inventors: Vyakarnam, Murty N. (New York, NY); Zimmerman, Mark C. (East Brunswick, NJ); Scopelianos, Angelo George (Whitehouse Station, NJ); Chun, Iksoo (Flemington, NJ); Melican, Mora C. (Bridgewater, NJ); Bazilio, Clairene A. (Plainfield, NJ); Roller, Mark B. (Nor
Assignee: Ethicon, Inc. (Somerville, NJ)
Date of First Priority Issue: Wednesday June 30th, 1999
Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
Patent Number: 6303136This teaches novel ways of encapsulating cells so that the immune system of the host does not reject them.
Inventors: Li, Rebecca (Needham, MA); Rein, David (Providence, RI)
Assignee: Neurotech S.A. (Evry, FR)
Date of First Priority Issue: Monday April 13th, 1998