Patents
Combination of G-CSF with a chemotherapeutic agent for stem cell mobilization
Patent Number: 6162427This patent teaches that a more potent stimulation of hematopoietic stem cell mobilization can be achieved by combining G-CSF with cyclophosphamide, as opposed to administration of either alone.
Inventors: Baumann, Matthias (Karl-Ludwig-Strasse, DE); Ochlich, Peter-Paul (Wallonenstrasse, DE)
Assignee: Roche Diagnostics GmbH (Mannheim, DE)
Date of First Priority Issue: Wednesday December 20th, 1995
Method for modulating hemopoiesis
Patent Number: 6159940This patent seems ripe for development. It covers a composition of matter that appears, at face value, relatively easy to synthesize and is useful for the stimulation of hematopoietic stem cells.
Inventors: Deigin, Vladislav I. (North York, CA); Korotkov, Andrei M. (Moscow, RU)
Assignee: Immunotech Developments Inc. (Toronto, CA)
Date of First Priority Issue: Wednesday February 28th, 1996
Use of GHRH-RP to stimulate stem cell factor production
Patent Number: 6159934This patent teaches that Sertoli cells make stem cell factor (which is interesting since people are co-culturing sertoli cells with islets from treating diabetes)...and that production of stem cell factor from sertoli cells may be upregulated by administration of the hormone GHRH-RP.
Inventor: Pescovitz, Ora H. (Carmel, IN)
Assignee: Indiana University Foundation (Bloomington, IN)
Date of First Priority Issue: Wednesday December 20th, 1995
Uses of Wnt polypeptides
Patent Number: 6159462This patent provides composition of matter for various peptides that are derived frim Wnt that are capable of stimulating stem cell expansion.
Inventors: Matthews, William (Woodside, CA); Austin, Timothy W. (Morgan Hill, CA)
Assignee: Genentech, Inc. (So. San Francisco, CA)
Date of First Priority Issue: Friday August 16th, 1996
Use of c-kit ligand with TNF-.alpha. and hematopoietic factors for the expansion or differentiation of hematopoietic cells
Patent Number: 6159461Combinations of cytokines are provided in this patent for expanding the number of hematopoietic stem cells. Cytokines include stem cell factor, tnf-alpha, and pixy. This is somewhat interesting since TNF alpha is usually considered to inhibit hematopoiesis.
Inventors: Besmer, Peter (New York, NY); Buck, Jochen (New York, NY); Moore, Malcolm A. S. (New York, NY); Nocka, Karl (Harvard, MA)
Assignee: Sloan-Kettering Institute for Cancer Research (New York, NY)
Date of First Priority Issue: Thursday April 23rd, 1992
Use of leukemia inhibitory factor and endothelin antagonists
Patent Number: 6156733This patent teaches how to treat heart failure by administration of antagonists to endothelin and LIF.
Inventors: Ferrara, Napoleone (San Francisco, CA); King, Kathleen (Pacifica, CA); Luis, Elizabeth (San Francisco, CA); Mather, Jennie P. (Millbrae, CA); Paoni, Nicholas F. (Belmont, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Date of First Priority Issue: Monday April 24th, 1995
Bioartificial extracellular matrix containing hydrogel matrix derivatized with cell adhesive peptide fragment
Patent Number: 6156572This patent provides novel compositions of matter that are useful for growing stem cells and neurons derived thereof for the purpose of implantation into the host. Specific matrices are provided.
Inventors: Bellamkonda, Ravi (Boston, MA); Ranieri, John P. (Lausanne, CH); Aebischer, Patrick (Lutry, CH)
Assignee: Neurotech S.A. (Evry, FR)
Date of First Priority Issue: Wednesday July 20th, 1994
Use of interleukin-7 to stimulate proliferation of hematopoietic cell precursors
Patent Number: 6156301This patent teaches the use of IL-7 for stimulation of hematopoiesis, as well as increasing the output of lymphocytes. IL-7 has several interesting properties, including the ability to support homeostatic expansion of T cells.
Inventors: Namen, Anthony E. (Seattle, WA); Goodwin, Raymond G. (Seattle, WA); Lupton, Stephen D. (Seattle, WA); Mochizuki, Diane Y. (Seattle, WA)
Assignee: Sanofi-Synthelabo (Paris, FR)
Date of First Priority Issue: Monday October 26th, 1987
Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
Patent Number: 6150164This patent teaches how to make a cell-seeded bioreactor so as to grow various types of kidney cells onto a hollow fiber filter for the generation of an "artificial kidney".
Inventor: Humes, H. David (Ann Arbor, MI)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Monday September 30th, 1996
Manipulation of non-terminally differentiated cells using the notch pathway
Patent Number: 6149902This patent teaches how to expand stem cells of ectodermal, endodermal and mesodermal origin without inducing differentiation, by the activation of the notch pathway. This patent could be a very strong base for development of regenerative cell populations either allogeneic or autologous.
Inventors: Artavanis-Tsakonas, Spyridon (Hamden, CT); Fortini, Mark Edward (New Haven, CT); Matsuno, Kenji (New Haven, CT)
Assignee: Yale University (New Haven, CT)
Date of First Priority Issue: Monday September 25th, 1995