Patents
Neuronal uses of BMP-11
Patent Number: 6340668The bone morphogenic proteins (BMPs) are able to stimulate various regenerative capabilities, including in the hematopoietic system, and especially in cartilage and bone. This patent teaches that BMP-11 is able to increase survival of neurons both in vitro and in vivo. This patent is useful for stimulation of neuronal stem cells, as well as for culture of neurons generated from stem cells...
Inventors: Celeste, Anthony J. (Hudson, MA); Wozney, John M. (Hudson, MA); Thies, R. Scott (Andover, MA)
Assignee: Genetics Institute, Inc. (Cambridge, MA)
Date of First Priority Issue: Wednesday May 12th, 1993
Selective expansion of target cell populations
Patent Number: 6338942This patent seems very interesting. It covers ways of selectively inducing proliferation of certain cell populations while "weeding out" cells that are not desirable. This patent is very useful in selection of stem cells and their progeny.
Inventors: Kraus, Morey (Worcester, MA); Wilder, Paul T. (Boylston, MA); Friberg, Jill (Seattle, WA)
Assignee: T. Breeders, Inc. (Worcester, MA)
Date of First Priority Issue: Friday May 19th, 1995
Molecular marker for muscle stem cells
Patent Number: 6337184This patent claims that expression of the anti-apoptotic gene bcl-2 can be used as a marker for stem cells of the muscle. The problem is that bcl-2 is an intracellular molecule, therefore it is difficult to selectively purify based on its expression. If a colourogenic substrate for bcl-2 can be discovered or already exists, this would greatly increase the value of the current patent.
Inventor: Miller, Jeffrey B. (Cambridge, MA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday April 1st, 1997
Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
Patent Number: 6335195This patent teaches that angiotensinogen I, II, and analogues thereof, are useful for the stimulation of mesenchymal and/or hematopoietic stem cell proliferation and/differentiation.
Inventors: Rodgers, Kathleen E. (Long Beach, CA); DiZerega, Gere S. (Pasadena, CA)
Assignee: Maret Corporation (Newport Beach, CA)
Date of First Priority Issue: Tuesday January 28th, 1997
Method of producing an undifferentiated avian cell culture using avian primordial germ cells
Patent Number: 6333192This patent teaches novel ways of generating chicken embryonic stem cells. This patent is useful for veterinary applications, as well, it may be transferrable to other species.
Inventors: Petitte, James N. (Raleigh, NC); Chang, Il-Kuk (Raleigh, NC)
Assignee: North Carolina State University (Raleigh, NC)
Date of First Priority Issue: Monday August 9th, 1999
Porous tissue scaffoldings for the repair of regeneration of tissue
Patent Number: 6333029This patent provides compositions of matter, and their uses, for generation of foams and various implantable structures that can function as scaffolds for the generation of artificial tissues.
Inventors: Vyakarnam, Murty N. (Edison, NJ); Zimmerman, Mark C. (East Brunswick, NJ); Scopelianos, Angelo George (Whitehouse Station, NJ); Roller, Mark B. (North Brunswick, NJ); Gorky, David V. (Flemington, NJ)
Assignee: Ethicon, Inc. (Somerville, NJ)
Date of First Priority Issue: Wednesday June 30th, 1999
Cumulus cells as nuclear donors
Patent Number: 6331659This patent provides the use of cumulus cells as donors of nuclei for the purpose of cloning animals with the exception of humans.
Inventors: Wakayama, Teruhiko (Honolulu, HI); Yanagimachi, Ryuzo (Honolulu, HI)
Assignee: University of Hawaii (Honolulu, HI)
Date of First Priority Issue: Wednesday January 21st, 1998
Human enbryonic germ cell and methods of use
Patent Number: 6331406This patent provides a new type of cell that can function as a stem cell, or is useful in the generation of stem cells. The cell population is characterized and is isolated from embryonic gonadal ridges.
Inventors: Gearhart, John D. (Baltimore, MD); Shamblott, Michael Joseph (Baltimore, MD)
Assignee: The John Hopkins University School of Medicine (Baltimore, MD)
Date of First Priority Issue: Monday March 31st, 1997
Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
Patent Number: 6328960This patent teaches the use of mesenchymal stem cells as biological immunosuppressants for prevention of graft rejection.
Inventors: McIntosh, Kevin R. (Ellicott City, MD); Mosca, Joseph D. (Ellicott City, MD); Klyushnenkova, Elena N. (Baltimore, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Monday January 19th, 1998
Methods and articles for regenerating living tissue
Patent Number: 6328765This patent teaches how to generate a vascularized tissue in vitro for subsequent implantation in vivo.
Inventors: Hardwick, William R. (Flagstaff, AZ); Thomson, Robert C. (Flagstaff, AZ); Cleek, Robert L. (Flagstaff, AZ); Mane, Shrikant M. (Flagstaff, AZ); Cook, Alonzo D. (Flagstaff, AZ)
Assignee: Gore Enterprise Holdings, Inc. (Newark, DE)
Date of First Priority Issue: Thursday December 3rd, 1998