Patents
Stem cell factor
Patent Number: 6204363This patent covers the composition of matter for a stem cell expansion protein named "stem cell factor", this is the ligand for c-kit.
Inventors: Zsebo, Krisztina M. (Thousand Oaks, CA); Bosselman, Robert A. (Thousand Oaks, CA); Suggs, Sidney V. (Newbury Park, CA); Martin, Francis H. (Thousand Oaks, CA)
Assignee: Amgen Inc. (Thousand Oaks, CA)
Date of First Priority Issue: Monday October 16th, 1989
Primate embryonic stem cells
Patent Number: 6200806This is one of the patents that cover embryonic stem cells. These patents are under much controversy since they cover the composition of matter for all embryonic stem cells.
Inventor: Thomson, James A. (Madison, WI)
Assignee: Wisconsin Alumni Research Foundation (Madison, WI)
Date of First Priority Issue: Friday January 20th, 1995
Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration
Patent Number: 6200606This patent covers the use of adipose derived stem cells for the generation of cartilage and bones.
Inventors: Peterson, Dale R. (Carmel, IN); Nousek-Goebl, Nancy (Fishers, IN)
Assignee: DePuy Orthopaedics, Inc. (Warsaw, IN)
Date of First Priority Issue: Tuesday January 16th, 1996
Thymosin .alpha.1 promotes tissue repair, angiogenesis and cell migration
Patent Number: 6197751Thymosin is expressed by the thymus and is associated with immune stimulation. In this patent the ability of thymosin to augment regeneration of tissue, as well as stimulate stem cells is patented. It is interesting that the production of thymosin actually decreases, as well as general thymic function with age. This patent may be a way to induce longevity by administration of thymosin.
Inventors: Malinda, Katherine M. (Millersville, MD); Kleinman, Hynda K. (Kensington, MD); Goldstein, Allan L. (Washington, DC)
Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC)
Date of First Priority Issue: Friday November 7th, 1997
Embryonic germ cells, method for making same, and using the cells to produce a chimeric porcine
Patent Number: 6194635This patent teaches how to generate embryonic germ cells. These cells may be used for transgenic and knockout experiments, as well as for generation of stem cells with unique properties.
Inventors: Anderson, Gary B. (Davis, CA); Shim, Hosup (Davis, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Date of First Priority Issue: Tuesday January 9th, 1996
Parthenogenic oocyte activation
Patent Number: 6194202This patent covers the generation of embryonic stem cells through parthenogenesis in cows. Parthenogenesis involves activating the oocyte to differentiate in absence of sperm.
Inventors: Susko-Parrish, Joan L. (Monona, WI); Northey, David L. (Madison, WI); Leibfried-Rutledge, M. Lorraine (Madison, WI); Stice, Steven L. (DeForest, WI)
Assignee: Infigen, Inc. (DeForest, WI)
Date of First Priority Issue: Wednesday February 10th, 1993
Mouse embryonic stem cell lines
Patent Number: 6190910This patent teaches the generation of several embryonic stem cell lines that are useful for creation of knockout mouse models.
Inventors: Kusakabe, Moriaki (Ibaragi, JP); Kamon, Toshio (Tokyo, JP)
Assignee: The Institute of Physical and Chemical Research (Saitama, JP)
Date of First Priority Issue: Thursday March 21st, 1996
Apparatus and method for collecting blood from an umbilical cord
Patent Number: 6190368This patent covers a medical device that is useful for extraction of cord blood so as to avoid the need for letting the cord blood drop by gravity into the collection receptacle.
Inventors: Kuypers, Franciscus A. (El Cerrito, CA); Cole, Robert B. (Alamo, CA); Meyst, Richard P. (Valley Center, CA); Gorton, Lanny A. (San Diego, CA); Wright, James I. (Villa Park, CA)
Assignee: Children's Hospital Medical Center of Northern California (Oakland, CA)
Date of First Priority Issue: Tuesday May 14th, 1996
Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells
Patent Number: 6184035This patent teaches ways of growing muscle stem cells through exposure to low oxygen tension and other tissue culture media.
Inventors: Csete, Marie (South Pasadena, CA); Doyle, John (South Pasadena, CA); Wold, Barbara (San Marino, CA)
Assignee: California Institute of Technology (Pasadena, CA)
Date of First Priority Issue: Wednesday November 18th, 1998
Medicinal preparation based on fetal cell suspension having immune substituting effect for patients with acquired immune deficiency syndrome (HIV infection)
Patent Number: 6184033This patent teaches the administration of fetal cells, including stem cells, for the treatment of HIV infection. Various stem cells are known to secrete anti-inflammatory compounds such as TGF-beta. One possible mechanism of action is that stem cells secrete these antiinflammatory compounds, which in turn inhibit NF-kappa B, which does not allow for the HIV to replicate.
Inventor: Smikodub, Alexandr Ivanovich (Kiev, UA)
Assignee: Centr Embrionalnikh Tkaney "Emcell" (Kiev, UA)
Date of First Priority Issue: Wednesday August 9th, 1995