Patents
Method of differentiating erythrocyte progenitor cells
Patent Number: 6147052Disclosed is the novel protein "Erythroid Differentiation and Denucleation Factor" (EDDF) which is capable of inducing production of red blood cells from hematopoietic stem cells both in vitro and in vivo. Methods of stimulating hematopoietic stem cells to generate various lineages of cells are important in medicine. It will be interesting to see if the EDDF also has similarity to EPO in terms...
Inventor: Chau, Raymond Ming Wah (Hong Kong, CN)
Assignee: KM Biotech, Inc. (Montebello, CA)
Date of First Priority Issue: Thursday December 5th, 1996
Proliferation of hepatocyte precursors
Patent Number: 6146889Disclosed are culture conditions and compositions of matter that are useful for expansion of liver stem cells. This patent is useful not only for the generation of single cell hepatocytes, but may be used with other scaffold patents in order to generate artificial liver lobes.
Inventors: Reid, Lola M. (Chapel Hill, NC); Agelli, Maria (New Providence, NJ)
Assignee: Albert Einstein College of Medicine of Yeshiva University, a division of Yeshiva University (Bronx, NY)
Date of First Priority Issue: Wednesday August 7th, 1991
Method of enriching for mammalian stem cells
Patent Number: 6146888In this patent an antibiotic resistance gene is placed under the control of a promoter associated with stem cells. This way only the stem cells will live while the other cells will die when exposed to the antibiotic.
Inventors: Smith, Austin Gerard (Edinburgh, GB); Mountford, Peter Scott (Elsfernwid, AU)
Assignee: The University of Edinburgh (GB)
Date of First Priority Issue: Thursday April 21st, 1994
In vitro-derived genetically altered human neutrophil precursor cells and methods for administering the same
Patent Number: 6146623This patent covers genetic transfection of stem cells that give rise to neutrophils. Transfection of this cell population may be performed to enhance their ability to proliferate, or may be performed to endow them with increased antibacterial activities.
Inventors: Bender, James G. (Lindenhurst, IL); Maples, Phillip B. (Waukegan, IL); Smith, Stephen (Arlington Heights, IL); Unverzagt, Kristen L. (Palatine, IL); Van Epps, Dennis E. (Cary, IL)
Assignee: Nexell Therapeutics Inc. (Irvine, CA)
Date of First Priority Issue: Monday March 23rd, 1992
Assembled scaffolds for three dimensional cell culturing and tissue generation
Patent Number: 6143293This patent covers a multilayered scaffold that can be seeded with stem cells, other types of cells, and/or growth factors for the generation of three dimensional tissues in culture.
Inventors: Weiss, Lee E. (Pittsburgh, PA); Calvert, Jay Wynn (Pittsburgh, PA)
Assignee: Carnegie Mellon (Pittsburgh, PA); University of Pittsburgh (Pittsburgh, PA)
Date of First Priority Issue: Thursday March 26th, 1998
Compositions of myeloid-cell-suppressive chemokines
Patent Number: 6143289Disclosed are methods of inhibiting production of myeloid lineage hematologic cells through the administration of various members of the chemokine family. Chemokines useful for inhibiting myeloid cell production include MIP1 alpha, and beta, IL-8, PF4, and MCAF.
Inventors: Broxmeyer, Hal E. (Indianapolis, IN); Cooper, Scott (Indianapolis, IN); Mantel, Charles (Indianapolis, IN); Lu, Li (Indianapolis, IN)
Assignee: Indiana University Foundation (Bloomington, IN)
Date of First Priority Issue: Wednesday December 9th, 1992
Methods and compositions to improve germ cell and embryo survival and function
Patent Number: 6140121This patent provides compounds that are capable of increasing the viability of germ cells and embryos both in vitro and in vivo.
Inventors: Ellington, Joanna E. (Valleyford, WA); Oliver, Sylvia Adams (Spokane, WA)
Assignee: Advanced Reproduction Technologies, Inc. (Valleyford, WA)
Date of First Priority Issue: Sunday September 10th, 1995
Isolated and modified porcine cerebral cortical cells
Patent Number: 6140116This patent covers a type of stem cell, specifically xenogeneic pig cerebral cortical cells. These cells, when treated so as to not elicit immune rejection, are useful for the treatment of various neurodegenerative disorders.
Inventor: Dinsmore, Jonathan (Brookline, MA)
Assignee: Diacrin, Inc. (Charlestown, MA)
Date of First Priority Issue: Tuesday November 8th, 1994
Preparation of cell seeded ceramic compositions
Patent Number: 6139578This patent provides scaffolds and various compositions for their manufacture so that the structures made may be seeded with stem cells and/or other types of cells for tissue engineering purposes.
Inventors: Lee, Dosuk D. (Brookline, MA); Rey, Christian (Castanet, FR); Aiolova, Maria (Brookline, MA)
Assignee: Etex Corporation (Cambridge, MA)
Date of First Priority Issue: Friday May 19th, 1995
Human jagged polypeptide, encoding nucleic acids and methods of use
Patent Number: 6136952This patent covers the composition of matter of JAGGED and various peptide derivatives. JAGGED is important embryonically for development, as well it has stimulatory activity on a wide variety of stem cells.
Inventors: Li, Linheng (Seattle, WA); Hood, Leroy (Seattle, WA)
Assignee: University of Washington (Seattle, WA)
Date of First Priority Issue: Wednesday June 25th, 1997