Patents
Human growth-associated methyltransferases
Patent Number: 6132714This patent covers the composition of matter for several methyltransferases that are associated with stem cell renewal. These methyltransferases may be associated with activity of numerous cell types in addition to hair follicle stem cells.
Inventors: Tang, Y. Tom (San Jose, CA); Yue, Henry (Sunnyvale, CA); Guegler, Karl J. (Menlo Park, CA); Shah, Purvi (Sunnyvale, CA)
Assignee: Incyte Pharmaceuticals, Inc. (Palo Alto, CA)
Date of First Priority Issue: Monday April 13th, 1998
Liver regeneration using pancreas cells
Patent Number: 6132708While some patents cover the generation of islet like cells from hepatocytes by transfection with PDX-1, this patent covers the generation of live cells through insertion of pancreatic cells into the spleen (in one embodiment). If anything, this patent attests to the plasticity of various cellular populations.
Inventor: Grompe, Markus (Portland, OR)
Assignee: Oregon Health Sciences University (Portland, OR)
Date of First Priority Issue: Friday October 10th, 1997
Cell seeding of ceramic compositions
Patent Number: 6132463This patent covers compositions of matter useful for generation of bone grafts and artificial bones either in vitro or in vivo.
Inventors: Lee, Dosuk D. (Brookline, MA); Rey, Christian (Castanet, FR); Aiolova, Maria (Brookline, MA)
Assignee: Etex Corporation (Cambridge, MA)
Date of First Priority Issue: Friday May 19th, 1995
Human stem cell antigen 2
Patent Number: 6130061This patent covers a new protein that is expressed on various types of stem cells. This protein can be used for purification of stem cells from tissue, or for assessment of stem cell populations in various in vitro culture systems.
Inventors: Ni, Jian (Rockville, MD); Yu, Guo-Liang (Darnestown, MD); Gentz, Reiner (Silver Spring, MD); Gocayne, Jeannine D. (Potomac, MD)
Assignee: Human Genome Sciences, Inc. (Rockville, MD)
Date of First Priority Issue: Thursday November 9th, 1995
Liver stem cell
Patent Number: 6129911This patent covers the stem cell for livers. Given the strong regenerative capacity of the liver, the characterization of stem cells of this organ is of great interest. Specific markers and methods of expanding liver stem cells are provided. The patent is currently owned by a company called MultiCell.
Inventor: Faris, Ronald A. (Providence, RI)
Assignee: Rhode Island Hospital, A LifeSpan Partner (Providence, RI)
Date of First Priority Issue: Friday July 10th, 1998
Methods of obtaining compositions enriched for hematopoietic stem cells, antibodies for use therein, compositions derived therefrom and methods of use thereof
Patent Number: 6127135This patent covers a novel marker of stem cells which the inventors call EM10. This patent is useful for identifying the stem cell content of a population of cells.
Inventors: Hill, Beth Louise (Mountain View, CA); Rozler, Elen (Mountain View, CA); Chen, Benjamin P. (Fremont, CA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Wednesday June 7th, 1995
Mobilization of peripheral blood precursor cells by .beta.(1,3)-glucan
Patent Number: 6117850This patent teaches how to mobilize stem cells through administration of beta glucan and various derivatives of it. The use of other immune stimulants and TLR agonists should be evaluated for mobilization in future.
Inventors: Patchen, Myra L. (Framingham, MA); Bleicher, Paul (Newton, MA)
Assignee: The Collaborative Group, Ltd. (Stony Brook, NY)
Date of First Priority Issue: Monday August 28th, 1995
Retinal stem cells
Patent Number: 6117675This patent covers retinal stem cells. These stem cells are useful for the treatment of a variety of ocular disorders including viral retinitis, blind spots, or loss of color vision.
Inventors: van der Kooy, Derek (Toronto, CA); McInnes, Roderick (Ontario, CA); Chiasson, Bernard (York, CA); Tropepe, Vincenzo (Toronto, CA)
Assignee: HSC Research and Development Limited Partnership (Toronto, CA)
Date of First Priority Issue: Wednesday September 25th, 1996
Compositions of mononuclear phagocytes useful for promoting axonal regeneration
Patent Number: 6117424This patent covers induction of neural regeneration through administration of monocytes and other immune cells. The immune cells may be administered for the treatment of spinal cord injury. This is actually in clinical trials right now.
Inventors: Eisenbach-Schwartz, Michal (Rehovot, IL); Spiegler, Orly (Rehovot, IL); Hirschberg, David L. (Stanford, CA)
Assignee: Yeda Research and Development Co. Ltd. (Rehovot, IL)
Date of First Priority Issue: Friday September 15th, 1995
Hemoregulatory compounds
Patent Number: 6114357This patent covers unique compositions of matter that stimulate the proliferation of hematopoietic stem cells.
Inventors: Bhatnagar, Pradip Kumar (Exton, PA); Heerding, Dirk Andries (Malvern, PA); Hartmann, Michael (Linz, AT); Hiebl, Johann (Linz, AT); Kremminger, Peter (Asten, AT); Rovenszky, Franz (Linz, AT)
Assignee: SmithKline Beecham Corporation (Philadelphia, PA); Nycomed Austria GmbH (Linz, AT)
Date of First Priority Issue: Monday November 13th, 1995