Patents
Primate embryonic stem cells
Patent Number: 5843780This is one of the composition of matter patents on embryonic stem cells. It belongs to what is called the "WARF Patents" covering the use and production of human and primate embryonic stem cells.
Inventor: Thomson, James A. (Madison, WI)
Assignee: Wisconsin Alumni Research Foundation (Madison, WI)
Date of First Priority Issue: Friday January 20th, 1995
Characterization of a human hematopoietic progenitor cell antigen
Patent Number: 5843633This patent covers the antigen known as AC133 or CD133. This antigen is useful for purification of hematopoietic stem cells, as well as stem cells with angiogenic activity.
Inventors: Yin, Amy (San Jose, CA); Miraglia, Sheri (Alameda, CA); Buck, David W. (Half Moon Bay, CA)
Assignee: Amcell Corporation (Sunnyvale, CA)
Date of First Priority Issue: Friday April 26th, 1996
Peripheralization of hematopoietic stem cells
Patent Number: 5843438This patent covers the use of anti-VLA-4 and anti-VCAM antibodies for mobilizing stem cells from the bone marrow. Stem cell mobilization is induced by the antibodies blocking the binding of the hematopoietic stem cells to the bone marrow stroma.
Inventor: Papayannopoulou, Thalia (Seattle, WA)
Assignee: Board of Regents University of Washington (Seattle, WA)
Date of First Priority Issue: Friday November 13th, 1992
Controlling proliferation of cells before and after encapsulation in a bioartificial organ by gene transformation
Patent Number: 5843431This patent covers the use of certain compositions of matter for the generation of implantable cells and stem cells. In some embodiments the cells are treated so as to not elicit an immune response. In other embodiments the proliferation of the cells in the encapsulation devices is controlled.
Inventors: Schinstine, Malcolm (Ben Salem, PA); Shoichet, Molly S. (Toronto, CA); Gentile, Frank T. (Warwick, RI); Hammang, Joseph P. (Barrington, RI); Holland, Laura M. (Horsham, PA); Cain, Brian M. (Everett, MA); Doherty, Edward J. (Mansfield, MA); Winn, Shelley R
Assignee: CytoTherapeutics, Inc.
Date of First Priority Issue: Wednesday July 20th, 1994
Methods of stimulating hematopoietic cells with flt3-ligand
Patent Number: 5843423This patent covers the stimulation of hematopoietic stem cells with flt-3 ligand. This cytokine is used in many stem cell stimulation/expansion cocktails...additionally flt-3 ligand is one of the few cytokines that can preferentially induce expansion of tissue dendritic cells.
Inventors: Lyman, Stewart D. (Seattle, WA); Beckmann, M. Patricia (Poulsbo, WA)
Assignee: Immunex Corporation (Seattle, WA)
Date of First Priority Issue: Monday May 24th, 1993
Phenotypic characterization of the hematopoietic stem cell
Patent Number: 5840580This patent covers the combination of various phenotypic markers for the extraction of hematopoietic stem cells. For example, CD34+, CD38-, HLA-DR- is one phenotype of hematopoietic stem cell described.
Inventors: Terstappen, Leon W. (Huntingdon Valley, PA); Loken, Michael R. (Mercer Island, WA); Huang, Shiang (San Ramon, CA); Olweus, Johanna (Fremont, CA); Lund-Johansen, Fridtjof (Fremont, CA)
Assignee: Becton Dickinson and Company (Franklin Lakes, NJ)
Date of First Priority Issue: Tuesday May 1st, 1990
Monoclonal antibodies for human mesenchymal stem cells
Patent Number: 5837539This patent covers the use of specific antibodies for the isolation and detection of mesenchymal stem cells. The antibodies are deposited at ATCC and can be purchased publically.
Inventors: Caplan, Arnold I. (Cleveland Heights, OH); Haynesworth, Stephen E. (Cleveland Heights, OH)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Friday November 16th, 1990
Method of treating heart failure using leukemia inhibitory factor antagonists optionally with endothelin antagonists
Patent Number: 5837241This patent covers antagonizing either or both the endothelin receptor and the LIF receptor. Methods of action by which this combination inhibits heart failure may have to do with modulation of stem cell function.
Inventors: Ferrara, Napoleone (San Francisco, CA); King, Kathleen (Pacifica, CA); Luis, Elizabeth (San Francisco, CA); Mather, Jennie P. (Millbrae, CA); Paoni, Nicholas F. (Belmont, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Date of First Priority Issue: Tuesday April 25th, 1995
Uses of recombinant colony stimulating factor-1
Patent Number: 5837229Covered in this patent is the use of the cytokine currently named M-CSF, for the expansion of hematopoietic stem cells and their differentiation along the myeloid lineage. Mice that are knocked out for M-CSF do not have functional macrophages, but also do not have tumor associated angiogenesis.
Inventors: Ralph, Peter (Orinda, CA); Chong, Kong T. (Union City, CA)
Assignee: Chiron Corporation (Emeryville, CA)
Date of First Priority Issue: Tuesday November 17th, 1998
Process and media for the growth of human epithelia
Patent Number: 5834312This patent covers a liquid composition that is useful for the growth of epithelial cells and various stem cells that differentiate along the epithelial lineages. Relevant types of cells generated by this culture could be corneal epithelial or gingival cells.
Inventor: Wille, Jr., John J. (Trenton, NJ)
Assignee: Hy-Gene, Inc. (Ventura, CA)
Date of First Priority Issue: Monday January 29th, 1990