Patents
Cerebellum-derived growth factors
Patent Number: 5912326This patent discloses a polypeptide that is involved in the formation of various brain structures. This polypeptide is useful for stem cell differentiation and expansion.
Inventor: Chang, Han (Mountain View, CA)
Assignee: President and Fellows of Harvard College (Cambridge, MA); Leland S. Stanford University (Palo Alto, CA)
Date of First Priority Issue: Friday September 8th, 1995
Stem cell immobilization
Patent Number: 5912177This patent covers methods of "grabbing" stem cells by virtue of a fibrin matrix together with RGD binding motifs. The attachment of stem cells to various structures may be useful as a means of harvesting stem cells.
Inventors: Turner, Marc Leighton (South Queensferry, GB); Murphy, William Gerrard (Edinburgh, GB)
Assignee: Common Services Agency (Edinburgh, GB)
Date of First Priority Issue: Wednesday June 29th, 1994
Process and media for the growth of human cornea and gingiva
Patent Number: 5912175This patent teaches how to grow specialized epithelial structures from stem cells such as cornea, gingiva, and ureters. Specific tissue culture conditions and media are provided for growing the stem cells and inducing their differentiation into the desired tissue.
Inventor: Wille, Jr., John J. (Trenton, NJ)
Assignee: Hy-Gene, Inc. (Ventura, CA)
Date of First Priority Issue: Sunday January 21st, 1990
Stem cell and lymphocyte storage
Patent Number: 5912174This patent provides gelatin-based compounds that allow for the preservation of various cells, including stem cells of the hematopoietic lineage.
Inventors: Scheer, David (Guilford, CT); Babior, Bernard M. (San Diego, CA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Thursday June 25th, 1992
Method for isolating stem cells expressing flk-1 receptors
Patent Number: 5912133This patent teaches that cells expressing flk-1 on their surface may be stem cells. It specifically provides methods of using flk-1, alone, or in combination with other markers for the purification of stem cells.
Inventor: Lemischka, Ihor R. (Princeton, NJ)
Assignee: The Trustees of Princeton University (Princeton, NJ)
Date of First Priority Issue: Tuesday April 2nd, 1991
In vitro chondrogenic induction of human mesenchymal stem cells
Patent Number: 5908784This patent teaches how to induce differentiation of mesenchymal stem cells into chondrocytes. The tissue culture conditions described may be used for generation of artificial cartilage. This patent is useful in combination with the numerous patents that describe three dimensional matrices and scaffolds useful for making cartilage.
Inventors: Johnstone, Brian (Shaker Heights, OH); Yoo, Jung (Shaker Heights, OH)
Assignee: Case Western Reserve University (Cleveland, OH)
Date of First Priority Issue: Thursday November 16th, 1995
Chemically defined medium for human mesenchymal stem cells
Patent Number: 5908782This patent provides serum free media for the growth, expansion, and differentiation of mesenchymal stem cells. Having media that can be used for expanding mesenchymal stem cells was a critical part of Osiris developing its advanced clinical program.
Inventors: Marshak, Daniel R. (Cold Spring Harbor, NY); Holecek, James J. (Solon, OH)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Monday June 5th, 1995
DNA encoding GM-CSF and a method of producing GM-CSF protein
Patent Number: 5908763This patent covers composition of matter for the hematopoietic cytokine granulocyte monocyte colony stimulating factor.
Inventors: Clark, Steven C. (Winchester, MA); Kaufman, Randal J. (Boston, MA); Wong, Gordon G. (Cambridge, MA); Wang, Elizabeth A. (Carlisle, MA)
Assignee: Novartis Corporation (Basel, CH)
Date of First Priority Issue: Friday July 6th, 1984
Method of reconstituting hematopoietic cells using monoclonal antibodies to the stem cell factor receptor
Patent Number: 5906938This patent provides antibodies that stimulate the receptor c-kit and allow for enhancement of hematopoiesis. This patent may be useful not only for stimulation of hematopoiesis, but for stimulating other tissue specific stem cells that also express c-kit...these include endogenous cardiac and other muscle stem cells.
Inventors: Broudy, Virginia C. (Seattle, WA); Lin, Nancy (Seattle, WA)
Assignee: Board of Regents of the University of Washington (Seattle, WA)
Date of First Priority Issue: Wednesday May 1st, 1991
Mesenchymal stem cells for cartilage repair
Patent Number: 5906934This patent covers the use of mesenchymal stem cells for generation of artificial bone and cartilage. It is interesting that this patent was issued in light of Osiris's domination of the field of mesenchymal stem cells. This patent should be read in light of the other mesenchymal stem cell patents.
Inventors: Grande, Daniel A. (Sea Cliff, NY); Lucas, Paul A. (Macon, GA)
Assignee: Morphogen Pharmaceuticals, Inc. (New York, NY); North Shore University Hospital Research Corporation (Manhasset, NY)
Date of First Priority Issue: Tuesday March 14th, 1995