Patents
Use of stem cell factor and soluble interleukin-6 receptor for the ex vivo expansion of hematopoietic multipotential cells
Patent Number: 5861315This patent covers the use of the c-kit ligand together with stimulators of gp130 for the in vitro and ex vivo expansion of hematopoietic stem cells. Since the c-kit ligand is important for other types of stem cells, it will be interesting to see if this patent can be used for expansion of, say for example, cardiac stem cells.
Inventor: Nakahata, Tatsutoshi (Tokyo, JP)
Assignee: Amgen Inc. (Thousand Oaks, CA); Tosoh Corporation (Thousand Oaks, CA)
Date of First Priority Issue: Wednesday November 16th, 1994
Method of isolating bile duct progenitor cells
Patent Number: 5861313This patent covers a type of stem cell that is isolated from the bile duct that can be induced to differentiate into various types of pancreatic cells including islets.
Inventors: Pang, Kevin K. (Belmont, MA); Homa, Monica W. (Marblehead, MA)
Assignee: Ontogeny, Inc. (Cambridge, MA)
Date of First Priority Issue: Wednesday June 7th, 1995
Control of cell growth in a bioartificial organ with extracellular matrix coated microcarriers
Patent Number: 5858747This patent covers several means of growing stem cells and their derivatives, as well as generating scaffolds and implantable means that protect the stem cells from the immunological reaction of the host.
Inventors: Schinstine, Malcolm (Ben Salem, PA); Shoichet, Molly S. (Toronto, CA); Gentile, Frank T. (Warwick, RI); Hammang, Joseph P. (Barrington, RI); Holland, Laura M. (Horsham, PA); Cain, Brian M. (Everett, MA); Doherty, Edward J. (Mansfield, MA); Winn, Shelley R
Assignee: CytoTherapeutics, Inc.
Date of First Priority Issue: Wednesday July 20th, 1994
Stem cell inhibiting proteins
Patent Number: 5856301This patent covers the inhibition of stem cell proliferation through administration of MIP-1 alpha or LD78. It is interesting to ask whether these compounds also inhibit proliferation of leukemic stem cells. If they do not, the use of these compounds may selectively protect healthy hematopoietic stem cells but allow killing of the leukemic hematopoietic stem cells by chemotherapy.
Inventors: Craig, Stewart (Oxford, GB2); Hunter, Michael George (Buckinghamshire, GB2); Edwards, Richard Mark (Oxford, GB2); Czaplewski, Lloyd George (Oxford, GB2); Gilbert, Richard James (Oxford, GB2)
Assignee: British Biotech Pharmaceuticals Limited (Oxford, GB)
Date of First Priority Issue: Wednesday December 23rd, 1992
Biomatrix for soft tissue regeneration
Patent Number: 5855619This patent provides various compositions of matter that are useful for the administration of stem cells in order to heal or regenerate soft tissue.
Inventors: Caplan, Arnold I. (Cleveland Heights, OH); Fink, David J. (Shaker Heights, OH); Young, Randell G. (Ellicott City, MD)
Assignee: Case Western Reserve University (Cleveland, OH)
Date of First Priority Issue: Monday June 6th, 1994
Stimulating the differentiation of preadipocytic cells and therapies based thereon
Patent Number: 5854292This patent covers the use of the retinoid receptor pathway to induce differentiation of adipocyte stem cells in vivo and therefore make a patient who is insulin resistant, insulinn sensitive.
Inventors: Ailhaud, Gerard (Nice, FR); Grimaldi, Paul (Nice, FR); Safonova, Irina (Nice, FR); Shroot, Braham (Antibes, FR); Reichert, Uwe (Pont Du Loup, FR)
Assignee: Centre International De Recherches Dermatologiques Galderma (Valbonne, FR)
Date of First Priority Issue: Wednesday August 2nd, 1995
Methods and compositions of growth control for cells encapsulated within bioartificial organs
Patent Number: 5853717This patent teaches ways of encapsulating stem cells and their derivatives. It provides various means and devices for the generation of artificial organs. Additionally, the patent teaches how to optimize the viability of the stem cells in the artificial organ.
Inventors: Schinstine, Malcolm (Ben Salem, PA); Shoichet, Molly S. (Toronto, CA); Gentile, Frank T. (Warwick, RI); Hammang, Joseph P. (Barrington, RI); Holland, Laura M. (Horsham, PA); Cain, Brian M. (Everett, MA); Doherty, Edward J. (Mansfield, MA); Winn, Shelley R
Assignee: CytoTherapeutics, Inc. (Lincoln, RI)
Date of First Priority Issue: Monday June 20th, 1994
Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides
Patent Number: 5851984Wnt peptides are critical in embryonic development and cell fate determination. In this patent Wnt peptides are used for the expansion and differentiation of hematopoietic stem cells. I predict that these peptides would also be useful for expansion of non-hematopoietic stem cells as well.
Inventors: Matthews, William (Woodside, CA); Austin, Timothy W. (Morgan Hill, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Date of First Priority Issue: Friday August 16th, 1996
In vitro growth and proliferation of multipotent neural stem cells and their progeny
Patent Number: 5851832This patent covers a type of neural stem cell that can differentiate into neurons and neuron supporting cells. This patent also teaches ways of expanding and differentiating the neural stem cells.
Inventors: Weiss, Samuel (Alberta, CA); Reynolds, Brent (Alberta, CA); Hammang, Joseph P. (Barrington, RI); Baetge, E. Edward (Barrington, RI)
Assignee: Neurospheres, Ltd. (CA)
Date of First Priority Issue: Monday July 8th, 1991
Methods for prevention and/or treatment of neutropenia
Patent Number: 5851534Inventors: Raheman, Fazal (Burlington, MA); Istrate, Nicolae (Lexington, MA); Muni, Gita (North Reading, MA); Brauner, Edgard (Brighton, MA)
Assignee: Dynagen, Inc. (Cambridge, MA)
Date of First Priority Issue: Friday May 3rd, 1996