Patents
Stem cell factor receptor-(c-kit)-specific monoclonal antibody A3C6E2
Patent Number: 5808002This patent covers the use of an antibody to c-kit for the quantification and extraction of hematopoietic stem cells. Since non-hematopoietic stem cells also express c-kit, this antibody may have other uses than originally contemplated.
Inventor: Buhring, Hans-Jorg (Tubingen, DE)
Assignee: Eberhard-Karls-Universitat Tubingen (Tubingen, DE)
Date of First Priority Issue: Wednesday January 10th, 1996
Use of interferon .gamma. for the inhibition of proliferation and differentiation of primitive hematopoietic progenitor cells
Patent Number: 5807744This patent teaches that the Th1 cytokine interferon gamma inhibits proliferation of hematopoietic stem cells. In one use, this cytokine may be administered to cultures of bone marrow harvested from cancer patients for autologous transplant, the administration of interferon gamma would protect the stem cells from chemotherapy which would kill residual cancer cells. Additionally, the interferon...
Inventors: Berneman, Zwi (Antwerp, BE); Van Bockstaele, Dirk (Edegem, BE); Snoeck, Hans-Willem (Antwerp, BE)
Assignee: Boehringer Mannheim GmbH (Mannheim, DE)
Date of First Priority Issue: Saturday August 13th, 1994
Pluripotential quiescent stem cell population
Patent Number: 5807686This patent covers an early hematopoietic stem cell that is identified by unique physical characteristics. It is interesting to see how this patent is read in light of other patents dealing with hematopoietic stem cell populations.
Inventors: Wagner, John E. (Plymouth, MN); Lebkowski, Jane S. (Portola Valley, CA)
Assignee: Regents of University of Minnesota (Minneapolis, MN); Rhone-Poulenc Rorer Pharmaceuticals (Collegeville, PA)
Date of First Priority Issue: Monday November 16th, 1992
Bone marrow transplantation
Patent Number: 5806529This patent teaches that administration of "mega-dose" hematopoietic stem cell grafts may be useful for circuventing the requirement of completely ablating the recipient immune system. Use of this patent may allow for reduced neutropenic times and increased survival after bone marrow transplantation.
Inventors: Reisner, Yair (Old Jaffa, IL); Martelli, Massimo (Perugia, IT)
Assignee: Yeda Research and Development Co. Ltd. (IL)
Date of First Priority Issue: Wednesday November 3rd, 1993
Blood-borne mesenchymal cells
Patent Number: 5804446This patent covers a type of stem cell that circulates and is mesenchymal in nature. The cell phenotype is CD34+ and CD45+, both being markers of hematopoietic and not classical mesenchymal stem cells.
Inventors: Cerami, Anthony (Shelter Island, NY); Bucala, Richard J. (New York, NY)
Assignee: The Picower Institute for Medical Research (Manhasset, NY)
Date of First Priority Issue: Friday February 26th, 1993
Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
Patent Number: 5800829This patent provides a method of isolating cells from the immune system through encapsulation. Specific means of generating this implantable device, and use with stem cells, as well as other populations of cells is disclosed.
Inventors: Dionne, Keith E. (Rehoboth, MA); Emerich, Dwaine F. (Providence, RI); Hoffman, Diane (Cambridge, MA); Sanberg, Paul R. (Spring Hill, FL); Christenson, Lisa (New Haven, CT); Hegre, Orion D. (Green Valley, AZ); Scharp, David W. (St. Louis, MO); Lacy, Paul E
Assignee: Brown University Research Foundation
Date of First Priority Issue: Thursday April 25th, 1991
Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
Patent Number: 5800828This patent teaches ways of growing cells in vivo in an environment that is protected from immunological attack. Specific ways of encapsulating cells, including stem cells, and their progeny are described. This patent is useful, in one embodiment, for the treatment of diabetes with artificially generated islets.
Inventors: Dionne, Keith E. (Rehoboth, MA); Emerich, Dwaine F. (Providence, RI); Hoffman, Diane (Cambridge, MA); Sanberg, Paul R. (Spring Hill, FL); Christenson, Lisa (New Haven, CT); Hegre, Orion D. (Green Valley, AZ); Scharp, David W. (St. Louis, MO); Lacy, Paul E
Assignee: Brown University Research Foundation
Date of First Priority Issue: Thursday April 25th, 1991
Method and construct for producing graft tissue from an extracellular matrix
Patent Number: 5800537This patent teaches how to decellularize various tissues and to use the remnants as a scaffold for seeding of stem cells. This patent is useful for tissue engineering of varous organs and anatomical structures.
Inventor: Bell, Eugene (Boston, MA)
Assignee: Tissue Engineering, Inc. (Boston, MA)
Date of First Priority Issue: Friday August 7th, 1992
Method for controlling proliferation and differentiation of cells encapsulated within bioartificial organs
Patent Number: 5795790This patent teaches the use of UV irradiation in order to render encapsulated cells mitotically inactive, but still metabolically active. This patent is useful for the generation of grafts that are implantable, for example an artificial pancreas.
Inventors: Schinstine, Malcolm (Ben Salem, PA); Shoichet, Molly S. (Toronto, CA); Gentile, Frank T. (Warwick, RI); Hammang, Joseph P. (Barrington, RI); Holland, Laura M. (Horsham, PA); Cain, Brian M. (Everett, MA); Doherty, Edward J. (Mansfield, MA); Winn, Shelley R
Assignee: Cytotherapeutics, Inc. (Lincoln, RI)
Date of First Priority Issue: Wednesday July 20th, 1994
Treatment of radiation-damaged bone marrow using galactosyl ceramides
Patent Number: 5767092The composition of matter described in this patent is actually a stimulator of NKT cells. In this patent, the composition, alpha galactosyl ceramide is described for the use of protecting the hematopoietic stem cell compartment from radiation or chemotherapy. It is unknown if these effects are directly mediated on the CD34+ hematopoietic stem cells, or if they are indirect through the activation...
Inventors: Koezuka, Yasuhiko (Takasaki, JP); Kabaya, Koji (Takasaki, JP); Motoki, Kazuhiro (Takasaki, JP)
Assignee: Kirin Beer Kabushiki Kaisha (Tokyo-to, JP)
Date of First Priority Issue: Thursday July 15th, 1993