Patents
Morphogen-induced liver regeneration
Patent Number: 5849686This patent provides various morphogens that can be administered in vivo for the induction of liver regeneration. This patent is useful alone, or in combination with exogenous stem cell delivery for treatment of hepatic disorders. This patent is especially interesting in light of recent work using cord blood stem cells for liver regeneration.
Inventors: Kuberasampath, Thangavel (Medway, MA); Rueger, David C. (Hopkinton, MA); Oppermann, Hermann (Medway, MA); Pang, Roy H. L. (Etna, NH); Cohen, Charles M. (Medway, MA)
Assignee: Creative BioMolecules, Inc.
Date of First Priority Issue: Monday March 11th, 1991
Mammalian multipotent neural stem cells
Patent Number: 5849553This patent covers neural stem cells that are transfected with various oncogenes so as to make them immortal. These cells would be highly beneficial for cell therapy of neurodegenerative diseases, if the safety issue of potential oncogenesis can be overcome.
Inventors: Anderson, David J. (Altadena, CA); Stemple, Derek L. (Newton, MA)
Assignee: California Institute of Technology (Pasadena, CA)
Date of First Priority Issue: Monday July 27th, 1992
Gene therapy using stromal cells
Patent Number: 5849287This patent covers the use of stromal cells for delivery of genes. Stromal cells can migrate systemically and when transfected with genes can serve as a stable source of protein production in a patient. I wonder what the difference is between the stromal cells described in this patent and the mesenchymal stem cells covered by Osiris?
Inventors: Greenberger, Joel S. (Lincoln, MA); Levine, Peter H. (Worcester, MA)
Assignee: Stromagene Corporation (Lincoln, MA); Gene Therapy Sciences, Inc. (Worcester, MA)
Date of First Priority Issue: Thursday February 2nd, 1989
Polypeptide capable of differentiating and maturing malignant cells into normal cells or capable of accelerating the formulation of erythroblasts
Patent Number: 5847078Disclosed is a novel peptide that is useful for terminally differentiating leukemic cells. This peptide could be generally used for luekemia therapy, but should also be considered in combination with some other differentiation inducing agents such as retinoic acid.
Inventors: Eto, Yuzuru (Yokohama-shi, Kanagawa-ken, JP); Tsuji, Tomoko (Kawasaki-shi, Kanagawa-ken, JP); Takano, Satoshi (Yokohama-shi, Kanagawa-ken, JP); Takezawa, Misako (Yokohama-shi, Kangawa-ken, JP); Yokogawa, Yasunori (Yamato-shi, Kanagawa-ken, JP); Shibai, Hi
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Wednesday July 2nd, 1986
Methods of using aminothiols to promote hematopoietic progenitor cell growth
Patent Number: 5846958This patent covers a small molecule that is useful for expansion of hematopoietic stem cells in vivo. This small molecule would be interesting to use in a depot formulation and administered together with local cell therapy for the stimulation of angiogenesis.
Inventors: Capizzi, Robert L. (Haverford, PA); List, Alan F. (Tucson, AZ)
Assignee: U.S. Bioscience, Inc. (West Conshohocken, PA); Arizona Board of Regents on Behalf of the University of Arizona (Tucson, AZ)
Date of First Priority Issue: Friday February 17th, 1995
Method of using exendin and GLP-1 to affect the central nervous system
Patent Number: 5846937This patent may be interesting for Amylin from San Diego to look at. Why it is interesting is because, I believe, Amylin actually has taken some of the compounds described in this patent to the clinic. This patent teaches the use of GLP-1 and/or exendin-4 for modulation of central nervous system activity.
Inventor: Drucker, Daniel J. (Toronto, CA)
Assignee: 1149336 Ontario Inc. (Toronto, CA)
Date of First Priority Issue: Monday March 3rd, 1997
Media compositions for three-dimensional mammalian tissue growth under microgravity culture conditions
Patent Number: 5846807This patent describes ways of growing tissue in space or under microgravity conditions. This patent could be used not only for generation of medically important implants, but also for production of various artificial meats and foods for astronauts to eat while in space.
Inventor: Goodwin, Thomas J. (Friendswood, TX)
Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, DC)
Date of First Priority Issue: Thursday June 30th, 1988
Blood-borne mesenchymal cells
Patent Number: 5846796This patent covers mesenchymal stem cells that are circulating in the blood. This patent is interesting since the cells covered contain the hematopoietic stem cell marker CD34, which is usually not believed to be expressed on mesenchymal stem cells. Additionally, the marker CD45, is usually a hematopoietic associated marker, but it too is also expressed on the mesenchymal stem cells that are...
Inventors: Cerami, Anthony (Shelter Island, NY); Bucala, Richard J. (New York, NY)
Assignee: The Picower Institute for Medical Research (Manhasset, NY)
Date of First Priority Issue: Friday February 26th, 1993
Infusion of neutrophil precursors for treatment of neutropenia
Patent Number: 5846529This patent covers ways of treating neutropenic patients through administration of stem cells that are committed to differentiating into neutrophils. This patent is useful for the treatment of patients that are suppressed in terms of white blood cell numbers.
Inventors: Smith, Stephen L. (Arlington Heights, IL); Qiao, Xiaoying (Waukegan, IL); Maciukas, Susan M. (El Cerrito, CA); Loudovaris, Maureen F. (Grayslake, IL); Bender, James G. (Lindenhurst, IL); Van Epps, Dennis E. (Cary, IL)
Assignee: Nexell Therapeutics, Inc. (Irvine, CA)
Date of First Priority Issue: Monday August 23rd, 1993
Vertebrate embryonic pattern-inducing proteins, and uses related thereto
Patent Number: 5844079This patent covers hedgehog proteins and their derivatives. These compositions of matter are very important for embryonic development and can be used for the expansion and differentiation of a wide variety of stem cells.
Inventors: Ingham, Philip W. (Summertown, GB2); McMahon, Andrew P. (Lexington, MA); Tabin, Clifford J. (Cambridge, MA)
Assignee: President and Fellows of Harvard College (Cambridge, MA)
Date of First Priority Issue: Thursday December 30th, 1993