Patents
Methods of isolating and detecting bone marrow stromal cells with VCAM-1-specific antibodies
Patent Number: 5827670This patent covers VCAM positive bone marrow stromal cells. These are the cells that support hematopoietic stem cell proliferation. Do mesenchymal stem cells have VCAM on them??
Inventors: Masinovsky, Boris (Bellevue, WA); Gallatin, William Michael (Mercer Island, WA); Simmons, Paul J. (Seattle, WA)
Assignee: Fred Hutchinson Cancer Research Center (Seattle, WA)
Date of First Priority Issue: Tuesday October 27th, 1998
In vitro method for obtaining an isolated population of mammalian neural crest stem cells
Patent Number: 5824489Covered is a method of purifying or extracting a type of stem cells from the fetal neural crest. This population of stem cells expresses low-affinity nerve growth factor receptor (LNGFR) and nestin and can differentiate into various cells of the neural lineage.
Inventors: Anderson, David J. (Altadena, CA); Stemple, Derek L. (Pasadena, CA)
Assignee: California Institute of Technology (Pasadena, CA)
Date of First Priority Issue: Tuesday July 21st, 1992
Peripheralization of hematopoietic stem cells
Patent Number: 5824304This patent teaches how to treat HIV by removal of mobilized stem cells (stem cell mobilization by anti-VLA4 antibody), administering chemo or radiotherapy, and then subsequently reinfusing the purified stem cells to reconstitute the hematopoietic system.
Inventor: Papayannopoulou, Thalia (Seattle, WA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday November 13th, 1992
Stimulation, production, culturing and transplantation of stem cells by fibroblast growth factors
Patent Number: 5817773This patent teaches that members of the FGF family are useful for expansion of hematopoietic stem cells. This is interesting since FGF-2 was actually used in the clinic for treatment of stroke. Although results were impressive in small subsets of patients, the adverse effects of systemic administration of this protein stopped its clinical development. According to this patent the systemic...
Inventors: Wilson, Elaine Lynette (New York, NY); Gabrilove, Janice (New York, NY)
Assignee: New York University (New York, NY); Sloan-Kettering Institute for Cancer Research (New York, NY)
Date of First Priority Issue: Friday June 8th, 1990
Method for providing trophic support for neurons comprising administering neurturin
Patent Number: 5817622This patent teaches that administration of neurturin can increase survival and induce expansion of neural stem cells. It would be interesting to see if neurturin can also effect hematopoiesis, given the similarity between stem cells of the hematopoietic and neural lineages.
Inventors: Johnson, Jr., Eugene M. (St. Louis, MO); Milbrandt, Jeffrey D. (St. Louis, MO); Kotzbauer, Paul T. (St. Louis, MO); Lampe, Patricia A. (St. Louis, MO)
Assignee: Washington University (St. Louis, MO)
Date of First Priority Issue: Monday August 28th, 1995
Methods of obtaining compositions enriched for hematopoietic stem cells, antibodies for use therein, compositions derived therefrom and methods of use thereof
Patent Number: 5814440Disclosed are methods of purifying hematopoietic stem cells using the antibody EM10.
Inventors: Hill, Beth Louis (Mountain View, CA); Rozler, Elen (Mountain View, CA); Chen, Benjamin P. (Fremont, CA)
Assignee: Systemix, Inc. (Palo Alto, CA)
Date of First Priority Issue: Wednesday June 7th, 1995
System for the in vivo delivery and expression of heterologous genes in the bone marrow
Patent Number: 5811407This patent teaches the transfection of bone marrow stem cells using a new type of vector. The vector disclosed is an alphavirus vector. Transfection by alphavirus has been performed in numerous situations and is actually in clinical trials.
Inventors: Johnston, Robert E. (Chapel Hill, NC); Davis, Nancy L. (Chapel Hill, NC); Simpson, Dennis A. (Pittsboro, NC)
Assignee: The University of North Carolina at Chapel Hill (Chapel Hill, NC)
Date of First Priority Issue: Wednesday February 19th, 1997
In vitro method for producing differentiated universally compatible human blood cells
Patent Number: 5811301This patent teaches ways of genetically modifying stem cells, and their progeny so as to generate a population of cells that is acceptable by all humanity.
Inventor: Cameron, Robert B. (San Francisco, CA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday November 16th, 1993
Connective tissue regeneration using human mesenchymal stem cell preparations
Patent Number: 5811094This is one of the original Osiris patents covering the therapeutic use of mesenchymal stem cells. In this patent mesenchymal stem cells are generated from the bone marrow and used to regenerate connective tissue such as bone or cartilage.
Inventors: Caplan, Arnold I. (Cleveland Heights, OH); Haynesworth, Stephen E. (Cleveland Heights, OH)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Friday November 16th, 1990
Pharmaceutical preparation based on fetal suspension and methods of treating acquired immune deficiency syndrome (HIV injection)
Patent Number: 5811089This patent covers the injection of fetal hematopoietic organs, and extracts thereof, for the treatment of HIV.
Inventors: Smikodub, Alexandr Ivanovich (Kiev, UA); Markov, Igor Semenovich (Kiev, UA); Pilipchak, Elena Makarovna (Kiev, UA)
Assignee: Centr Embrionainikh Tkaney "Emcell" (Kiev, UA)
Date of First Priority Issue: Tuesday December 14th, 1993