Patents
Methods for identifying fetal cells
Patent Number: 5750339Fetal to maternal trafficking of stem cells is a relatively undiscussed phenomena. This patent covers methods of detecting fetal cells in maternal circulation, in one embodiment through identification of cells expressing the immune suppressive molecule HLA-G
Inventor: Smith, J. Bruce (Philadelphia, PA)
Assignee: Thomas Jefferson University (Philadelphia, PA)
Date of First Priority Issue: Wednesday November 30th, 1994
Expansion of human hematopoietic progenitor cells in a liquid medium
Patent Number: 5744361This patent provide tissue culture reagents for the expansion of hematopoietic stem cells.
Inventors: Hoffman, Ronald (Palo Alto, CA); Brandt, John (Palo Alto, CA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday April 9th, 1991
Yolk sac stem cells and their uses
Patent Number: 5744347This patent covers an early hematopoietic stem cell that is derived from the yolk sac. The yolk sac is actually the first site, or one of the first sites of hematopoiesis during development.
Inventors: Wagner, Thomas E. (Albany, OH); Antczak, Michael R. (Albany, OH)
Assignee: Ohio University Edison Biotechnology Institute (Athens, OH)
Date of First Priority Issue: Friday January 16th, 1987
Protection of hemopoietic cells
Patent Number: 5739110This patent covers the use of the peptide AcSDKP for inhibiting hematopoietic stem cell proliferation and protecting the stem cells from radiation or chemotherapy. In addition, since the angiotensin-converting enzyme is responsible for degradation of AcSDKP, inhibition of ACE by clinically used inhibitors for the inhibition of hematopoiesis is provided. ACE inhibitors include captopril...
Inventors: Bogden, Arthur E. (West Yarmouth, MA); De Paillette, Evelyn Deschamps (Paris, FR)
Assignee: Biomeasure Inc. (Milford, MA); Societe de Conseils de Recherches Et D'Applications Scientifiques (FR)
Date of First Priority Issue: Monday September 12th, 1994
Lineage-directed induction of human mesenchymal stem cell differentiation
Patent Number: 5736396This patent teaches ways of inducing the differentiation of mesenchymal stem cells into bone, cartilage and other non-hematopoietic tissues.
Inventors: Bruder, Scott P. (Moreland Hills, OH); Caplan, Arnold I. (Cleveland Heights, OH); Haynesworth, Stephen E. (Cleveland Heights, OH)
Assignee: Case Western Reserve University (Cleveland, OH)
Date of First Priority Issue: Tuesday January 24th, 1995
Morphogen-induced periodontal tissue regeneration
Patent Number: 5733878This patent provides various morphogens, such as OP-1 for the regeneration of various dendal components, including tooth sockets.
Inventors: Kuberasampath, Thangavel (Medway, MA); Rueger, David C. (Hopkinton, MA); Oppermann, Hermann (Medway, MA); Cohen, Charles M. (Medway, MA); Pang, Roy H. L. (Etna, NH)
Assignee: Creative BioMolecules, Inc. (Hopkinton, MA)
Date of First Priority Issue: Friday August 30th, 1991
Enhancing bone marrow engraftment using MSCS
Patent Number: 5733542This patent teaches the use of mesenchymal stem cells to promote engraftment of hematopoietic stem cells. I wonder how this mesenchymal cell population is different that the stromal cell populations that are also used to promote engraftment?
Inventors: Haynesworth, Stephen E. (Cleveland Heights, OH); Caplan, Arnold I. (Cleveland Heights, OH); Gerson, Stanton L. (Pepper Pike, OH); Lazarus, Hillard M. (Shaker Heights, OH)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday November 16th, 1990
Hematopoietic cells: compositions and methods
Patent Number: 5733541This patent covers the use of osteoblasts to stimulate activity and function of hematopoietic stem cells. I wonder if osteoblasts can also stimulate the activity of other types of stem cells?
Inventors: Taichman, Russell S. (Ann Arbor, MI); Emerson, Stephen G. (Wayne, PA)
Assignee: The Regent of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Monday November 30th, -0001
Human hematopoietic stem cell
Patent Number: 5716827This is one of the patents on the composition of matter of hematopoietic stem cells, it covers a population of CD34+, Thy-1+ cells.
Inventors: Tsukamoto, Ann (Palo Alto, CA); Baum, Charles M. (Mountain View, CA); Aihara, Yukoh (Yokohama, JP); Weissman, Irving (Palo Alto, CA)
Assignee: SyStemix, Inc. (Palo Alto, CA)
Date of First Priority Issue: Friday March 30th, 1990
Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects
Patent Number: 5716616This patent teaches that stromal cells may be used for the treatment of various bone disorders, as well as regeneration of bone. How are these stromal cells related to the mesenchymal stem cells that Osiris is using?
Inventors: Prockop, Darwin J. (Philadelphia, PA); Pereira, Ruth F. (Lansdowne, PA); Leeper, Dennis B. (Wynnewood, PA); O'Hara, Michael D. (Wyncote, PA)
Assignee: Thomas Jefferson University (Philadelphia, PA)
Date of First Priority Issue: Tuesday March 28th, 1995