Patents
In vitro differentiation of CD34.sup.+ progenitor cells into T lymphocytes
Patent Number: 5677139This patent teaches how to generate T cells from hematopoietic stem cells in vitro. T cells may be used for immune stimulation, or in some other cases may be used for generation of T suppressor cells. If nuclear transfer can be performed in the starting population of cells, then patient-specific T cells may be generated.
Inventors: Johnson, R. Paul (Lexington, MA); Rosenzweig, Michael (Boston, MA); Scadden, David T. (Weston, MA)
Assignee: President and Fellows of Harvard College (Cambridge, MA)
Date of First Priority Issue: Friday April 21st, 1995
Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
Patent Number: 5677136This patent teaches that the protein CD59 may be used as a marker of hematopoietic stem cells both for identification, and also for purification.
Inventors: Simmons, Paul J. (Adelaide, AU); Hill, Beth L. (Mountain View, CA); Chen, Benjamin P. (Fremont, CA)
Assignee: Systemix, Inc. (Palo Alto, CA)
Date of First Priority Issue: Monday November 14th, 1994
Methods of enhancing bone marrow transplantation and treating burn wounds comprising administering human pluripotent granulocyte colony-stimulating factor
Patent Number: 5676941Like other hematopoietic cytokines, this patent teaches that hpG-CSF may be administered for the treatment of burn wounds.
Inventor: Souza, Lawrence M. (Thousand Oaks, CA)
Assignee: Amgen Inc. (Thousand Oaks, CA)
Date of First Priority Issue: Friday August 23rd, 1985
Increase in hematopoietic progenitor cells in peripheral blood by transforming growth factor .beta.
Patent Number: 5674843This patent teaches that the stem cell inhibitory compound TGF-beta may be administered for the purpose of mobilization.
Inventor: Carlino, Joseph A. (San Leandro, CA)
Assignee: Celtrix Pharmaceuticals, Inc. (Santa Clara, CA)
Date of First Priority Issue: Thursday September 2nd, 1993
Method for inhibiting growth of stem cells
Patent Number: 5674841Disclosed is a peptide that inhibits stem cell proliferation...it doesnt give a name for the peptide..
Inventors: Pragnell, Ian B. (Glasgow, GB6); Donaldson, Debra D. (Cambridge, MA); Graham, Gerald J. (Glasgow, GB6); Wong, Gordon G. (Jamaica Plain, MA)
Assignee: Genetics Institute, Inc. (Cambridge, MA)
Date of First Priority Issue: Monday September 25th, 1989
Laminin 5 for growth of pancreatic islet cells
Patent Number: 5672361This patent teaches that laminin-5 is very potent at stimulation of expansion of pancreatic islet cells from stem cells.
Inventors: Halberstadt, Craig (San Diego, CA); Grzesiak, John J. (Cardiff, CA)
Assignee: Desmos, Inc. (San Diego, CA)
Date of First Priority Issue: Friday March 29th, 1996
Human stem cell compositions and methods
Patent Number: 5672346This patent covers the CD34+, HLA-DR negative, c-kit positive, hematopoietic stem cell.
Inventors: Srour, Edward (Indianapolis, IN); Zanjani, Esmail (Reno, NV); Brandt, John E. (Indianapolis, IN); Hoffman, Ronald (Indianapolis, IN)
Assignee: Indiana University Foundation (Bloomington, IN)
Date of First Priority Issue: Monday July 27th, 1992
Pluripotential embryonic stem cells and methods of making same
Patent Number: 5670372This patent covers certain types of embryonic stem cells and their use for screening. Note that this patent has priority to the WARF patents...
Inventor: Hogan, Brigid L. M. (Brentwood, TN)
Assignee: Vanderbilt University
Date of First Priority Issue: Thursday October 8th, 1992
Methods and compositions for the ex vivo replication of human hematopoietic stem cells
Patent Number: 5670351This patent covers methods of expanding human hematopoietic stem cells through ex vivo transfection with various genes. Specific culture conditions are also provided. This patent can be used for post myeloablative reconsitution, but also, theoretically, for stimulation of angiogenesis by administration of the bone marrow stem cells into ischemia areas.
Inventors: Emerson, Stephen G. (Ann Arbor, MI); Clarke, Michael F. (Ann Arbor, MI); Palsson, Bernhard O. (Ann Arbor, MI); Schwartz, Richard M. (Ann Arbor, MI)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Thursday June 15th, 1989
Compositions containing cultured mitotic human stem cells
Patent Number: 5670147This patent teaches ways of expanding stem cell, including culture in IL-6 and GM-CSF.
Inventors: Emerson, Stephen G. (Ann Arbor, MI); Clarke, Michael F. (Ann Arbor, MI); Palsson, Bernhard O. (Ann Arbor, MI)
Assignee: Regents of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Thursday June 15th, 1989