Patents
Identification and isolation of human hematopoietic stem cells
Patent Number: 5643741This patent covers the identification of human hematopoietic stem cells by seeking out cells that express the markers CD34 and Thy1.
Inventors: Tsukamoto, Ann (Palo Alto, CA); Baum, Charles M. (Mountain View, CA); Aihara, Yukoh (Yokohama, JP); Weissman, Irving (Palo Alto, CA)
Assignee: Systemix, Inc. (Palo Alto, CA)
Date of First Priority Issue: Friday March 30th, 1990
Continuous centrifugation process for the separation of biological components from heterogeneous cell populations
Patent Number: 5641622This patent covers the use of continuous flow centrifuges and various systems for purification of homogeneous cells from a heterogeneous population. This patent may be useful for purifying stem cells from blood based on weight and other physical characteristics.
Inventors: Lake, William C. (Laguna Niguel, CA); Giesler, Richard (Deerfield, IL); Epps, Dennis Van (Cary, IL); Chapman, John R. (Lake Villa, IL); Martinson, Jeffrey A. (Mundelein, IL); Ellis, Dale R. (Wonder Lake, IL); Aono, Frederick (Arlington Heights, IL); Bisch
Assignee: Baxter International Inc. (Deerfield, IL)
Date of First Priority Issue: Thursday September 13th, 1990
Methods and device for culturing human hematopoietic cells and their precursors
Patent Number: 5635387This patent provide conditions and systems for the ex vivo expansion of hematopoietic stem cells. Specific cell concentrations, growth factors, and vessels are provided. This patent is useful for expansion of cells either in the autologous situation, or in situations where an allogeneic source is not sufficient, such as in cord blood transplants.
Inventors: Fei, Rui G. (Seattle, WA); Heimfeld, Shelly (Woodinville, WA); Minshall, Billy W. (Mill Creek, WA); Berenson, Ronald J. (Mercer Island, WA)
Assignee: CellPro, Inc. (Bothell, WA)
Date of First Priority Issue: Monday April 23rd, 1990
Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture
Patent Number: 5635386This patent provides culture conditions for in vitro pushing stem cells of the hematopoietic lineage to differentiate into various blood cells. This patent is useful for generation of "off the shelf" cells if a method is figured out how to "de-immunogenize" the cells.
Inventors: Palsson, Bernhard O. (Ann Arbor, MI); Armstrong, R. Douglas (Ann Arbor, MI); Clarke, Michael F. (Ann Arbor, MI); Emerson, Stephen G. (Ann Arbor, MI)
Assignee: The Regents of The University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Thursday June 15th, 1989
Non-lethal methods for conditioning a recipient for bone marrow transplantation
Patent Number: 5635156This patent teaches how to perform bone marrow transplantation, or transplantation of stem cells with hematopoietic potential, without completely ablating the recipient hematopoietic system. The patent uses various antibodies to not-completely deplete the host, but just enough so that the stem cells administered are not completely cleared away.
Inventor: Ildstad, Suzanne T. (Pittsburgh, PA)
Assignee: University of Pittsburgh (Pittsburgh, PA)
Date of First Priority Issue: Monday September 13th, 1993
In vivo use of human bone marrow for investigation and production
Patent Number: 5633426This is one of the patents on the human SCID mouse. It teaches methods of introducing human stem cells into a mouse that is immune compromized, so that the behaviour of human stem cells can be studied in a non-human model.
Inventors: Namikawa, Reiko (Palo Alto, CA); Kyoizumi, Seishi (Hiroshima, JP); McCune, Joseph M. (San Francisco, CA); Kaneshima, Hideto (Palo Alto, CA)
Assignee: Systemix, Inc. (Palo Alto, CA)
Date of First Priority Issue: Friday May 25th, 1990
Method of stimulating hematopoiesis with hemoglobin
Patent Number: 5631219This patent teaches that hemoglobin itself may have hematopoietic stem cell stimulatory properties. The ability of hemoglobin chains has been described by others for stimulation of stem cell proliferation, and in some cases inhibition. This patent covers purified hemoglobin, mutant hemoglobin, and various recombinant hemoglobins. In Feb 25, 1998, Somatogen was bought by Baxter for 189...
Inventors: Rosenthal, Gary J. (Boulder, CO); Gerber, Michael J. (Denver, CO)
Assignee: Somatogen, Inc. (Boulder, CO)
Date of First Priority Issue: Tuesday March 8th, 1994
Single chain peptide compounds having hemoregulatory activity
Patent Number: 5629293This is a composition of matter patent on a peptide that has stimulatory activity to stem cells of the hematopoietic system. This patent can be used for not only stimulating hematopoiesis in a patient, but also for other novel uses such as angiogenesis.
Inventors: Undheim, Kjell (Sandvika, NO); Kremminger, Peter (Liuz, AT); Hartmann, Michael (Pettenbach, AT)
Assignee: Nycomed Imaging AS (Oslo, NO)
Date of First Priority Issue: Tuesday June 2nd, 1992
Homeopathic dilutions of growth factors
Patent Number: 5629286This is a patent on using the technique of homeopathy (ultra-dilution with potentiation) in order to generate stem cell stimulants and other growth factors. This patent is very exciting...if the data is reproducible it could revolutionize medicine.
Inventor: Brewitt, Barbara (Seattle, WA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Thursday March 31st, 1994
Methods for treating disorders by administering radio frequency signals corresponding to growth factors
Patent Number: 5626617This patent teaches that stem cells can be expanded by applying radiofrequencies that correspond with growth factors. This is a very interesting approach since conceptually the radiofrequencies can be used as pharmaceuticals. This patent definately deserves further investigation.
Inventor: Brewitt, Barbara (Seattle, WA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Thursday March 31st, 1994